We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
8
Cytoband
q21.13
Chromosome location (bp)
78516340 - 78605267
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Protein kinase inhibitor
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P61925 [Direct mapping] cAMP-dependent protein kinase inhibitor alpha
Show all
A0A024R7Y9 [Target identity:100%; Query identity:100%] cAMP-dependent protein kinase inhibitor
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004860[protein kinase inhibitor activity] GO:0004862[cAMP-dependent protein kinase inhibitor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0006469[negative regulation of protein kinase activity] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0034236[protein kinase A catalytic subunit binding] GO:0051338[regulation of transferase activity] GO:0140678[molecular function inhibitor activity] GO:2000480[negative regulation of cAMP-dependent protein kinase activity]
P61925 [Direct mapping] cAMP-dependent protein kinase inhibitor alpha
Show all
A0A024R7Y9 [Target identity:100%; Query identity:100%] cAMP-dependent protein kinase inhibitor
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0004860[protein kinase inhibitor activity] GO:0004862[cAMP-dependent protein kinase inhibitor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0006469[negative regulation of protein kinase activity] GO:0010389[regulation of G2/M transition of mitotic cell cycle] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0034236[protein kinase A catalytic subunit binding] GO:0042308[negative regulation of protein import into nucleus] GO:0043086[negative regulation of catalytic activity] GO:0051338[regulation of transferase activity] GO:0140678[molecular function inhibitor activity] GO:2000480[negative regulation of cAMP-dependent protein kinase activity]
P61925 [Direct mapping] cAMP-dependent protein kinase inhibitor alpha
Show all
A0A024R7Y9 [Target identity:100%; Query identity:100%] cAMP-dependent protein kinase inhibitor
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004860[protein kinase inhibitor activity] GO:0004862[cAMP-dependent protein kinase inhibitor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0006469[negative regulation of protein kinase activity] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0034236[protein kinase A catalytic subunit binding] GO:0051338[regulation of transferase activity] GO:0140678[molecular function inhibitor activity] GO:2000480[negative regulation of cAMP-dependent protein kinase activity]
The Human Protein Atlas project is funded
