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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes RAS pathway related proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
20
Cytoband
q11.21
Chromosome location (bp)
31664452 - 31723989
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage-dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis, Endocytosis
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The proteins encoded by this gene are located at the outer mitochondrial membrane, and have been shown to regulate outer mitochondrial membrane channel (VDAC) opening. VDAC regulates mitochondrial membrane potential, and thus controls the production of reactive oxygen species and release of cytochrome C by mitochondria, both of which are the potent inducers of cell apoptosis. Alternative splicing results in multiple transcript variants encoding two different isoforms. The longer isoform acts as an apoptotic inhibitor and the shorter isoform acts as an apoptotic activator. [provided by RefSeq, Dec 2015]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q5TE63 [Target identity:100%; Query identity:100%] Bcl-2-like protein 1
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Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001836[release of cytochrome c from mitochondria] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005743[mitochondrial inner membrane] GO:0005759[mitochondrial matrix] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006897[endocytosis] GO:0006915[apoptotic process] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0008637[apoptotic mitochondrial changes] GO:0009605[response to external stimulus] GO:0016020[membrane] GO:0019050[suppression by virus of host apoptotic process] GO:0019901[protein kinase binding] GO:0030672[synaptic vesicle membrane] GO:0031410[cytoplasmic vesicle] GO:0031965[nuclear membrane] GO:0032465[regulation of cytokinesis] GO:0034097[response to cytokine] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0045202[synapse] GO:0046902[regulation of mitochondrial membrane permeability] GO:0046982[protein heterodimerization activity] GO:0051434[BH3 domain binding] GO:0051607[defense response to virus] GO:0051881[regulation of mitochondrial membrane potential] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:0097136[Bcl-2 family protein complex] GO:0097192[extrinsic apoptotic signaling pathway in absence of ligand] GO:1900118[negative regulation of execution phase of apoptosis] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902230[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage] GO:1902236[negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903077[negative regulation of protein localization to plasma membrane] GO:2001233[regulation of apoptotic signaling pathway] GO:2001240[negative regulation of extrinsic apoptotic signaling pathway in absence of ligand] GO:2001243[negative regulation of intrinsic apoptotic signaling pathway]
A0A0S2Z3C5 [Target identity:100%; Query identity:100%] Bcl-2-like protein 1
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Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001836[release of cytochrome c from mitochondria] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005743[mitochondrial inner membrane] GO:0005759[mitochondrial matrix] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006897[endocytosis] GO:0006915[apoptotic process] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0008637[apoptotic mitochondrial changes] GO:0009605[response to external stimulus] GO:0010507[negative regulation of autophagy] GO:0016020[membrane] GO:0019050[suppression by virus of host apoptotic process] GO:0019901[protein kinase binding] GO:0030672[synaptic vesicle membrane] GO:0031410[cytoplasmic vesicle] GO:0031965[nuclear membrane] GO:0032465[regulation of cytokinesis] GO:0034097[response to cytokine] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0045202[synapse] GO:0046902[regulation of mitochondrial membrane permeability] GO:0046982[protein heterodimerization activity] GO:0051434[BH3 domain binding] GO:0051607[defense response to virus] GO:0051881[regulation of mitochondrial membrane potential] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:0097136[Bcl-2 family protein complex] GO:0097143[PUMA-BCL-xl complex] GO:0097192[extrinsic apoptotic signaling pathway in absence of ligand] GO:1900118[negative regulation of execution phase of apoptosis] GO:1901029[negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902230[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage] GO:1902236[negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903077[negative regulation of protein localization to plasma membrane] GO:2000811[negative regulation of anoikis] GO:2001233[regulation of apoptotic signaling pathway] GO:2001240[negative regulation of extrinsic apoptotic signaling pathway in absence of ligand] GO:2001243[negative regulation of intrinsic apoptotic signaling pathway]
Q9H1R6 [Direct mapping] Bcl-2-like protein 1 A0A0S2Z3C5 [Target identity:100%; Query identity:100%] Bcl-2-like protein 1
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Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001836[release of cytochrome c from mitochondria] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005743[mitochondrial inner membrane] GO:0005759[mitochondrial matrix] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006897[endocytosis] GO:0006915[apoptotic process] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0008637[apoptotic mitochondrial changes] GO:0009605[response to external stimulus] GO:0010507[negative regulation of autophagy] GO:0016020[membrane] GO:0019050[suppression by virus of host apoptotic process] GO:0019901[protein kinase binding] GO:0030672[synaptic vesicle membrane] GO:0031410[cytoplasmic vesicle] GO:0031965[nuclear membrane] GO:0032465[regulation of cytokinesis] GO:0034097[response to cytokine] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0045202[synapse] GO:0046902[regulation of mitochondrial membrane permeability] GO:0046982[protein heterodimerization activity] GO:0051434[BH3 domain binding] GO:0051607[defense response to virus] GO:0051881[regulation of mitochondrial membrane potential] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:0097136[Bcl-2 family protein complex] GO:0097143[PUMA-BCL-xl complex] GO:0097192[extrinsic apoptotic signaling pathway in absence of ligand] GO:1900118[negative regulation of execution phase of apoptosis] GO:1901029[negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902230[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage] GO:1902236[negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903077[negative regulation of protein localization to plasma membrane] GO:2000811[negative regulation of anoikis] GO:2001233[regulation of apoptotic signaling pathway] GO:2001240[negative regulation of extrinsic apoptotic signaling pathway in absence of ligand] GO:2001243[negative regulation of intrinsic apoptotic signaling pathway]
Q9H1R6 [Direct mapping] Bcl-2-like protein 1 Q5TE63 [Target identity:100%; Query identity:100%] Bcl-2-like protein 1
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Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001836[release of cytochrome c from mitochondria] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005743[mitochondrial inner membrane] GO:0005759[mitochondrial matrix] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006897[endocytosis] GO:0006915[apoptotic process] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0008637[apoptotic mitochondrial changes] GO:0009605[response to external stimulus] GO:0016020[membrane] GO:0019050[suppression by virus of host apoptotic process] GO:0019901[protein kinase binding] GO:0030672[synaptic vesicle membrane] GO:0031410[cytoplasmic vesicle] GO:0031965[nuclear membrane] GO:0032465[regulation of cytokinesis] GO:0034097[response to cytokine] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0045202[synapse] GO:0046902[regulation of mitochondrial membrane permeability] GO:0046982[protein heterodimerization activity] GO:0051434[BH3 domain binding] GO:0051607[defense response to virus] GO:0051881[regulation of mitochondrial membrane potential] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:0097136[Bcl-2 family protein complex] GO:0097192[extrinsic apoptotic signaling pathway in absence of ligand] GO:1900118[negative regulation of execution phase of apoptosis] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902230[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage] GO:1902236[negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903077[negative regulation of protein localization to plasma membrane] GO:2001233[regulation of apoptotic signaling pathway] GO:2001240[negative regulation of extrinsic apoptotic signaling pathway in absence of ligand] GO:2001243[negative regulation of intrinsic apoptotic signaling pathway]
Q5QP59 [Direct mapping] Bcl-2-like protein 1 A0A0S2Z3C5 [Target identity:100%; Query identity:100%] Bcl-2-like protein 1
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Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001836[release of cytochrome c from mitochondria] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005743[mitochondrial inner membrane] GO:0005759[mitochondrial matrix] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006897[endocytosis] GO:0006915[apoptotic process] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0008637[apoptotic mitochondrial changes] GO:0009605[response to external stimulus] GO:0010507[negative regulation of autophagy] GO:0016020[membrane] GO:0019050[suppression by virus of host apoptotic process] GO:0019901[protein kinase binding] GO:0030672[synaptic vesicle membrane] GO:0031410[cytoplasmic vesicle] GO:0031965[nuclear membrane] GO:0032465[regulation of cytokinesis] GO:0034097[response to cytokine] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0045202[synapse] GO:0046902[regulation of mitochondrial membrane permeability] GO:0046982[protein heterodimerization activity] GO:0051434[BH3 domain binding] GO:0051607[defense response to virus] GO:0051881[regulation of mitochondrial membrane potential] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:0097136[Bcl-2 family protein complex] GO:0097143[PUMA-BCL-xl complex] GO:0097192[extrinsic apoptotic signaling pathway in absence of ligand] GO:1900118[negative regulation of execution phase of apoptosis] GO:1901029[negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902230[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage] GO:1902236[negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903077[negative regulation of protein localization to plasma membrane] GO:2000811[negative regulation of anoikis] GO:2001233[regulation of apoptotic signaling pathway] GO:2001240[negative regulation of extrinsic apoptotic signaling pathway in absence of ligand] GO:2001243[negative regulation of intrinsic apoptotic signaling pathway]
Q5QP56 [Direct mapping] Bcl-2-like protein 1 A0A0S2Z3C5 [Target identity:100%; Query identity:100%] Bcl-2-like protein 1
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Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001836[release of cytochrome c from mitochondria] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005743[mitochondrial inner membrane] GO:0005759[mitochondrial matrix] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006897[endocytosis] GO:0006915[apoptotic process] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0008637[apoptotic mitochondrial changes] GO:0009605[response to external stimulus] GO:0010507[negative regulation of autophagy] GO:0016020[membrane] GO:0019050[suppression by virus of host apoptotic process] GO:0019901[protein kinase binding] GO:0030672[synaptic vesicle membrane] GO:0031410[cytoplasmic vesicle] GO:0031965[nuclear membrane] GO:0032465[regulation of cytokinesis] GO:0034097[response to cytokine] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0045202[synapse] GO:0046902[regulation of mitochondrial membrane permeability] GO:0046982[protein heterodimerization activity] GO:0051434[BH3 domain binding] GO:0051607[defense response to virus] GO:0051881[regulation of mitochondrial membrane potential] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:0097136[Bcl-2 family protein complex] GO:0097143[PUMA-BCL-xl complex] GO:0097192[extrinsic apoptotic signaling pathway in absence of ligand] GO:1900118[negative regulation of execution phase of apoptosis] GO:1901029[negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902230[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage] GO:1902236[negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903077[negative regulation of protein localization to plasma membrane] GO:2000811[negative regulation of anoikis] GO:2001233[regulation of apoptotic signaling pathway] GO:2001240[negative regulation of extrinsic apoptotic signaling pathway in absence of ligand] GO:2001243[negative regulation of intrinsic apoptotic signaling pathway]
Q9H1R6 [Direct mapping] Bcl-2-like protein 1 A0A0S2Z3C5 [Target identity:100%; Query identity:100%] Bcl-2-like protein 1
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Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001836[release of cytochrome c from mitochondria] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005743[mitochondrial inner membrane] GO:0005759[mitochondrial matrix] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006897[endocytosis] GO:0006915[apoptotic process] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0008637[apoptotic mitochondrial changes] GO:0009605[response to external stimulus] GO:0010507[negative regulation of autophagy] GO:0016020[membrane] GO:0019050[suppression by virus of host apoptotic process] GO:0019901[protein kinase binding] GO:0030672[synaptic vesicle membrane] GO:0031410[cytoplasmic vesicle] GO:0031965[nuclear membrane] GO:0032465[regulation of cytokinesis] GO:0034097[response to cytokine] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0045202[synapse] GO:0046902[regulation of mitochondrial membrane permeability] GO:0046982[protein heterodimerization activity] GO:0051434[BH3 domain binding] GO:0051607[defense response to virus] GO:0051881[regulation of mitochondrial membrane potential] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:0097136[Bcl-2 family protein complex] GO:0097143[PUMA-BCL-xl complex] GO:0097192[extrinsic apoptotic signaling pathway in absence of ligand] GO:1900118[negative regulation of execution phase of apoptosis] GO:1901029[negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902230[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage] GO:1902236[negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903077[negative regulation of protein localization to plasma membrane] GO:2000811[negative regulation of anoikis] GO:2001233[regulation of apoptotic signaling pathway] GO:2001240[negative regulation of extrinsic apoptotic signaling pathway in absence of ligand] GO:2001243[negative regulation of intrinsic apoptotic signaling pathway]
A0A0S2Z3C5 [Target identity:100%; Query identity:100%] Bcl-2-like protein 1
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Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001836[release of cytochrome c from mitochondria] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005743[mitochondrial inner membrane] GO:0005759[mitochondrial matrix] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006897[endocytosis] GO:0006915[apoptotic process] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0008637[apoptotic mitochondrial changes] GO:0009605[response to external stimulus] GO:0010507[negative regulation of autophagy] GO:0016020[membrane] GO:0019050[suppression by virus of host apoptotic process] GO:0019901[protein kinase binding] GO:0030672[synaptic vesicle membrane] GO:0031410[cytoplasmic vesicle] GO:0031965[nuclear membrane] GO:0032465[regulation of cytokinesis] GO:0034097[response to cytokine] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0045202[synapse] GO:0046902[regulation of mitochondrial membrane permeability] GO:0046982[protein heterodimerization activity] GO:0051434[BH3 domain binding] GO:0051607[defense response to virus] GO:0051881[regulation of mitochondrial membrane potential] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:0097136[Bcl-2 family protein complex] GO:0097143[PUMA-BCL-xl complex] GO:0097192[extrinsic apoptotic signaling pathway in absence of ligand] GO:1900118[negative regulation of execution phase of apoptosis] GO:1901029[negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902230[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage] GO:1902236[negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903077[negative regulation of protein localization to plasma membrane] GO:2000811[negative regulation of anoikis] GO:2001233[regulation of apoptotic signaling pathway] GO:2001240[negative regulation of extrinsic apoptotic signaling pathway in absence of ligand] GO:2001243[negative regulation of intrinsic apoptotic signaling pathway]
A0A0S2Z3C5 [Target identity:100%; Query identity:100%] Bcl-2-like protein 1
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Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001836[release of cytochrome c from mitochondria] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005743[mitochondrial inner membrane] GO:0005759[mitochondrial matrix] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006897[endocytosis] GO:0006915[apoptotic process] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0008637[apoptotic mitochondrial changes] GO:0009605[response to external stimulus] GO:0010507[negative regulation of autophagy] GO:0016020[membrane] GO:0019050[suppression by virus of host apoptotic process] GO:0019901[protein kinase binding] GO:0030672[synaptic vesicle membrane] GO:0031410[cytoplasmic vesicle] GO:0031965[nuclear membrane] GO:0032465[regulation of cytokinesis] GO:0034097[response to cytokine] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0045202[synapse] GO:0046902[regulation of mitochondrial membrane permeability] GO:0046982[protein heterodimerization activity] GO:0051434[BH3 domain binding] GO:0051607[defense response to virus] GO:0051881[regulation of mitochondrial membrane potential] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:0097136[Bcl-2 family protein complex] GO:0097143[PUMA-BCL-xl complex] GO:0097192[extrinsic apoptotic signaling pathway in absence of ligand] GO:1900118[negative regulation of execution phase of apoptosis] GO:1901029[negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902230[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage] GO:1902236[negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903077[negative regulation of protein localization to plasma membrane] GO:2000811[negative regulation of anoikis] GO:2001233[regulation of apoptotic signaling pathway] GO:2001240[negative regulation of extrinsic apoptotic signaling pathway in absence of ligand] GO:2001243[negative regulation of intrinsic apoptotic signaling pathway]
A0A0S2Z3C5 [Target identity:100%; Query identity:100%] Bcl-2-like protein 1
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Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001836[release of cytochrome c from mitochondria] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005743[mitochondrial inner membrane] GO:0005759[mitochondrial matrix] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006897[endocytosis] GO:0006915[apoptotic process] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0008637[apoptotic mitochondrial changes] GO:0009605[response to external stimulus] GO:0010507[negative regulation of autophagy] GO:0016020[membrane] GO:0019050[suppression by virus of host apoptotic process] GO:0019901[protein kinase binding] GO:0030672[synaptic vesicle membrane] GO:0031410[cytoplasmic vesicle] GO:0031965[nuclear membrane] GO:0032465[regulation of cytokinesis] GO:0034097[response to cytokine] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0045202[synapse] GO:0046902[regulation of mitochondrial membrane permeability] GO:0046982[protein heterodimerization activity] GO:0051434[BH3 domain binding] GO:0051607[defense response to virus] GO:0051881[regulation of mitochondrial membrane potential] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:0097136[Bcl-2 family protein complex] GO:0097143[PUMA-BCL-xl complex] GO:0097192[extrinsic apoptotic signaling pathway in absence of ligand] GO:1900118[negative regulation of execution phase of apoptosis] GO:1901029[negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902230[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage] GO:1902236[negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903077[negative regulation of protein localization to plasma membrane] GO:2000811[negative regulation of anoikis] GO:2001233[regulation of apoptotic signaling pathway] GO:2001240[negative regulation of extrinsic apoptotic signaling pathway in absence of ligand] GO:2001243[negative regulation of intrinsic apoptotic signaling pathway]
A0A0S2Z3C5 [Target identity:100%; Query identity:100%] Bcl-2-like protein 1
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Transporters Transporter channels and pores Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM RAS pathway related proteins Cancer-related genes Candidate cancer biomarkers Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0001836[release of cytochrome c from mitochondria] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005739[mitochondrion] GO:0005741[mitochondrial outer membrane] GO:0005743[mitochondrial inner membrane] GO:0005759[mitochondrial matrix] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0006897[endocytosis] GO:0006915[apoptotic process] GO:0008630[intrinsic apoptotic signaling pathway in response to DNA damage] GO:0008637[apoptotic mitochondrial changes] GO:0009605[response to external stimulus] GO:0010507[negative regulation of autophagy] GO:0016020[membrane] GO:0019050[suppression by virus of host apoptotic process] GO:0019901[protein kinase binding] GO:0030672[synaptic vesicle membrane] GO:0031410[cytoplasmic vesicle] GO:0031965[nuclear membrane] GO:0032465[regulation of cytokinesis] GO:0034097[response to cytokine] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042981[regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0045202[synapse] GO:0046902[regulation of mitochondrial membrane permeability] GO:0046982[protein heterodimerization activity] GO:0051434[BH3 domain binding] GO:0051607[defense response to virus] GO:0051881[regulation of mitochondrial membrane potential] GO:0090201[negative regulation of release of cytochrome c from mitochondria] GO:0097136[Bcl-2 family protein complex] GO:0097143[PUMA-BCL-xl complex] GO:0097192[extrinsic apoptotic signaling pathway in absence of ligand] GO:1900118[negative regulation of execution phase of apoptosis] GO:1901029[negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway] GO:1902042[negative regulation of extrinsic apoptotic signaling pathway via death domain receptors] GO:1902230[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage] GO:1902236[negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway] GO:1903077[negative regulation of protein localization to plasma membrane] GO:2000811[negative regulation of anoikis] GO:2001233[regulation of apoptotic signaling pathway] GO:2001240[negative regulation of extrinsic apoptotic signaling pathway in absence of ligand] GO:2001243[negative regulation of intrinsic apoptotic signaling pathway]
The Human Protein Atlas project is funded
