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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
G-protein coupled receptors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
q13.4
Chromosome location (bp)
75081753 - 75096876
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Olfactory receptor bmed/24999593">1,2. Activated by the synthetic sandalwood odorant sandalore 3,4. Endogenous ligand is unknown (Probable). The activity of this receptor is probably mediated by G proteins which induce elevation of intracellular Ca(2+), a cAMP-dependent pathway and phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and p38 MAPKs 5,6. Activation of OR2AT4 induces proliferation, migration, and re-epithelialization during wound-healing processes of keratinocytes 7. Stimulation of OR2AT4 by sandalore promotes hair growth by decreasing apoptosis and increasing production of the anagen-prolonging growth factor IGF1 as well as other pathways involving various kinases 8....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
G-protein coupled receptor, Receptor, Transducer
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Olfaction, Sensory transduction
Gene summary (Entrez)i
Useful information about the gene from Entrez
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
GO:0004930[G protein-coupled receptor activity] GO:0004984[olfactory receptor activity] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007608[sensory perception of smell] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0050896[response to stimulus] GO:0050911[detection of chemical stimulus involved in sensory perception of smell] GO:0070374[positive regulation of ERK1 and ERK2 cascade]
GO:0004930[G protein-coupled receptor activity] GO:0004984[olfactory receptor activity] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007608[sensory perception of smell] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0050896[response to stimulus] GO:0050911[detection of chemical stimulus involved in sensory perception of smell] GO:0070374[positive regulation of ERK1 and ERK2 cascade]
GO:0004930[G protein-coupled receptor activity] GO:0004984[olfactory receptor activity] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007608[sensory perception of smell] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0050896[response to stimulus] GO:0050911[detection of chemical stimulus involved in sensory perception of smell] GO:0070374[positive regulation of ERK1 and ERK2 cascade]
GO:0004930[G protein-coupled receptor activity] GO:0004984[olfactory receptor activity] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007608[sensory perception of smell] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0050896[response to stimulus] GO:0050911[detection of chemical stimulus involved in sensory perception of smell] GO:0070374[positive regulation of ERK1 and ERK2 cascade]
GO:0004930[G protein-coupled receptor activity] GO:0004984[olfactory receptor activity] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007608[sensory perception of smell] GO:0016020[membrane] GO:0016021[integral component of membrane] GO:0050896[response to stimulus] GO:0050911[detection of chemical stimulus involved in sensory perception of smell] GO:0070374[positive regulation of ERK1 and ERK2 cascade]
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