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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Activating transcription factor 7 interacting protein
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
12
Cytoband
p13.1
Chromosome location (bp)
14365676 - 14502931
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Required for HUSH-mediated heterochromatin formation and gene silencing 1. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1 2. Stabilizes SETDB1, is required to stimulate histone methyltransferase activity of SETDB1 and facilitates the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) 3,4. Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells 5....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
ATF7IP is a multifunctional nuclear protein that associates with heterochromatin. It can act as a transcriptional coactivator or corepressor depending upon its binding partners (summary by Liu et al., 2009).[supplied by OMIM, Nov 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0003712[transcription coregulator activity] GO:0003714[transcription corepressor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005829[cytosol] GO:0006306[DNA methylation] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0016604[nuclear body] GO:0016887[ATP hydrolysis activity] GO:0031647[regulation of protein stability] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045898[regulation of RNA polymerase II transcription preinitiation complex assembly] GO:0050821[protein stabilization] GO:0090309[positive regulation of DNA methylation-dependent heterochromatin formation]
Q6VMQ6 [Direct mapping] Activating transcription factor 7-interacting protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0003712[transcription coregulator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005829[cytosol] GO:0006306[DNA methylation] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0016604[nuclear body] GO:0031647[regulation of protein stability] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045898[regulation of RNA polymerase II transcription preinitiation complex assembly] GO:0050821[protein stabilization] GO:0090309[positive regulation of DNA methylation-dependent heterochromatin formation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0003712[transcription coregulator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005829[cytosol] GO:0006306[DNA methylation] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0016604[nuclear body] GO:0031647[regulation of protein stability] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045898[regulation of RNA polymerase II transcription preinitiation complex assembly] GO:0050821[protein stabilization] GO:0090309[positive regulation of DNA methylation-dependent heterochromatin formation]
Q6VMQ6 [Direct mapping] Activating transcription factor 7-interacting protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003712[transcription coregulator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005829[cytosol] GO:0006306[DNA methylation] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0016604[nuclear body] GO:0031647[regulation of protein stability] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045898[regulation of RNA polymerase II transcription preinitiation complex assembly] GO:0050821[protein stabilization] GO:0090309[positive regulation of DNA methylation-dependent heterochromatin formation]
Q6VMQ6 [Direct mapping] Activating transcription factor 7-interacting protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003712[transcription coregulator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005829[cytosol] GO:0006306[DNA methylation] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0016604[nuclear body] GO:0031647[regulation of protein stability] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045898[regulation of RNA polymerase II transcription preinitiation complex assembly] GO:0050821[protein stabilization] GO:0090309[positive regulation of DNA methylation-dependent heterochromatin formation]
The Human Protein Atlas project is funded
