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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
19
Cytoband
q13.2
Chromosome location (bp)
38409051 - 38426305
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Functions as a cation- and diacylglycerol (DAG)-regulated nucleotide exchange factor activating Ras through the exchange of bound GDP for GTP 1,2,3,4. In neutrophils, participates in a phospholipase C-activating N-formyl peptide-activated GPCR (G protein-coupled receptor) signaling pathway by promoting Ras-mediated activation of PIK3CG/PI3Kgamma to promote neutrophil functional responses (By similarity). In CD117(+) dendritic cells and mast cells, participates in an lipopolysaccharide (LPS)-activated signaling pathway that stimulates the production of interferon-gamma and other pro-inflammatory cytokines by natural killer (NK) cells (By similarity). May function in mast cell differentiation 5,6,7,8. Does not appear to be required for the development of B-cells, DC-cells, T-cells, or NK-cells (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Guanine-nucleotide releasing factor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Differentiation
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium, Lipid-binding, Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q8TDF6 [Direct mapping] RAS guanyl-releasing protein 4
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005509[calcium ion binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007202[activation of phospholipase C activity] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0008283[cell population proliferation] GO:0009991[response to extracellular stimulus] GO:0016020[membrane] GO:0019992[diacylglycerol binding] GO:0030099[myeloid cell differentiation] GO:0030154[cell differentiation] GO:0030742[GTP-dependent protein binding] GO:0043547[positive regulation of GTPase activity] GO:0046579[positive regulation of Ras protein signal transduction] GO:0046872[metal ion binding] GO:0050790[regulation of catalytic activity] GO:0050896[response to stimulus]
Q8TDF6 [Direct mapping] RAS guanyl-releasing protein 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005509[calcium ion binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007202[activation of phospholipase C activity] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0008283[cell population proliferation] GO:0009991[response to extracellular stimulus] GO:0016020[membrane] GO:0019992[diacylglycerol binding] GO:0030099[myeloid cell differentiation] GO:0030154[cell differentiation] GO:0030742[GTP-dependent protein binding] GO:0043547[positive regulation of GTPase activity] GO:0046579[positive regulation of Ras protein signal transduction] GO:0046872[metal ion binding] GO:0050790[regulation of catalytic activity] GO:0050896[response to stimulus]
Q8TDF6 [Direct mapping] RAS guanyl-releasing protein 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005509[calcium ion binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007202[activation of phospholipase C activity] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0008283[cell population proliferation] GO:0009991[response to extracellular stimulus] GO:0016020[membrane] GO:0019992[diacylglycerol binding] GO:0030099[myeloid cell differentiation] GO:0030154[cell differentiation] GO:0030742[GTP-dependent protein binding] GO:0043547[positive regulation of GTPase activity] GO:0046579[positive regulation of Ras protein signal transduction] GO:0046872[metal ion binding] GO:0050790[regulation of catalytic activity] GO:0050896[response to stimulus]
Q8TDF6 [Direct mapping] RAS guanyl-releasing protein 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005509[calcium ion binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007202[activation of phospholipase C activity] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0008283[cell population proliferation] GO:0009991[response to extracellular stimulus] GO:0016020[membrane] GO:0019992[diacylglycerol binding] GO:0030099[myeloid cell differentiation] GO:0030154[cell differentiation] GO:0030742[GTP-dependent protein binding] GO:0043547[positive regulation of GTPase activity] GO:0046579[positive regulation of Ras protein signal transduction] GO:0046872[metal ion binding] GO:0050790[regulation of catalytic activity] GO:0050896[response to stimulus]
Q8TDF6 [Direct mapping] RAS guanyl-releasing protein 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007202[activation of phospholipase C activity] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0008283[cell population proliferation] GO:0009991[response to extracellular stimulus] GO:0016020[membrane] GO:0019992[diacylglycerol binding] GO:0030099[myeloid cell differentiation] GO:0030154[cell differentiation] GO:0030742[GTP-dependent protein binding] GO:0043547[positive regulation of GTPase activity] GO:0046579[positive regulation of Ras protein signal transduction] GO:0046872[metal ion binding] GO:0050790[regulation of catalytic activity] GO:0050896[response to stimulus]
Q8TDF6 [Direct mapping] RAS guanyl-releasing protein 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005509[calcium ion binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007202[activation of phospholipase C activity] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0008283[cell population proliferation] GO:0009991[response to extracellular stimulus] GO:0016020[membrane] GO:0019992[diacylglycerol binding] GO:0030099[myeloid cell differentiation] GO:0030154[cell differentiation] GO:0030742[GTP-dependent protein binding] GO:0043547[positive regulation of GTPase activity] GO:0046579[positive regulation of Ras protein signal transduction] GO:0046872[metal ion binding] GO:0050790[regulation of catalytic activity] GO:0050896[response to stimulus]
Q8TDF6 [Direct mapping] RAS guanyl-releasing protein 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005509[calcium ion binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007202[activation of phospholipase C activity] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0008283[cell population proliferation] GO:0009991[response to extracellular stimulus] GO:0016020[membrane] GO:0019992[diacylglycerol binding] GO:0030099[myeloid cell differentiation] GO:0030154[cell differentiation] GO:0030742[GTP-dependent protein binding] GO:0043547[positive regulation of GTPase activity] GO:0046579[positive regulation of Ras protein signal transduction] GO:0046872[metal ion binding] GO:0050790[regulation of catalytic activity] GO:0050896[response to stimulus]
Q8TDF6 [Direct mapping] RAS guanyl-releasing protein 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005509[calcium ion binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007202[activation of phospholipase C activity] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0008283[cell population proliferation] GO:0009991[response to extracellular stimulus] GO:0016020[membrane] GO:0019992[diacylglycerol binding] GO:0030099[myeloid cell differentiation] GO:0030154[cell differentiation] GO:0030742[GTP-dependent protein binding] GO:0043547[positive regulation of GTPase activity] GO:0046579[positive regulation of Ras protein signal transduction] GO:0046872[metal ion binding] GO:0050790[regulation of catalytic activity] GO:0050896[response to stimulus]
Q8TDF6 [Direct mapping] RAS guanyl-releasing protein 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005509[calcium ion binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007202[activation of phospholipase C activity] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0008283[cell population proliferation] GO:0009991[response to extracellular stimulus] GO:0016020[membrane] GO:0019992[diacylglycerol binding] GO:0030099[myeloid cell differentiation] GO:0030154[cell differentiation] GO:0030742[GTP-dependent protein binding] GO:0043547[positive regulation of GTPase activity] GO:0046579[positive regulation of Ras protein signal transduction] GO:0046872[metal ion binding] GO:0050790[regulation of catalytic activity] GO:0050896[response to stimulus]
Q8TDF6 [Direct mapping] RAS guanyl-releasing protein 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005509[calcium ion binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007202[activation of phospholipase C activity] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0008283[cell population proliferation] GO:0009991[response to extracellular stimulus] GO:0016020[membrane] GO:0019992[diacylglycerol binding] GO:0030099[myeloid cell differentiation] GO:0030154[cell differentiation] GO:0030742[GTP-dependent protein binding] GO:0043547[positive regulation of GTPase activity] GO:0046579[positive regulation of Ras protein signal transduction] GO:0046872[metal ion binding] GO:0050790[regulation of catalytic activity] GO:0050896[response to stimulus]
Q8TDF6 [Direct mapping] RAS guanyl-releasing protein 4
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005509[calcium ion binding] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007169[transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007202[activation of phospholipase C activity] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0008283[cell population proliferation] GO:0009991[response to extracellular stimulus] GO:0016020[membrane] GO:0019992[diacylglycerol binding] GO:0030099[myeloid cell differentiation] GO:0030154[cell differentiation] GO:0030742[GTP-dependent protein binding] GO:0043547[positive regulation of GTPase activity] GO:0046579[positive regulation of Ras protein signal transduction] GO:0046872[metal ion binding] GO:0050790[regulation of catalytic activity] GO:0050896[response to stimulus]
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