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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
20
Cytoband
q13.13
Chromosome location (bp)
50190830 - 50192668
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Important transcription factor regulating the expression of genes involved in immune and inflammatory responses 1,2,3,4. Also plays a significant role in adipogenesis, as well as in the gluconeogenic pathway, liver regeneration, and hematopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Its functional capacity is governed by protein interactions and post-translational protein modifications. During early embryogenesis, plays essential and redundant roles with CEBPA. Has a promitotic effect on many cell types such as hepatocytes and adipocytes but has an antiproliferative effect on T-cells by repressing MYC expression, facilitating differentiation along the T-helper 2 lineage. Binds to regulatory regions of several acute-phase and cytokines genes and plays a role in the regulation of acute-phase reaction and inflammation. Also plays a role in intracellular bacteria killing (By similarity). During adipogenesis, is rapidly expressed and, after activation by phosphorylation, induces CEBPA and PPARG, which turn on the series of adipocyte genes that give rise to the adipocyte phenotype. The delayed transactivation of the CEBPA and PPARG genes by CEBPB appears necessary to allow mitotic clonal expansion and thereby progression of terminal differentiation 5. Essential for female reproduction because of a critical role in ovarian follicle development (By similarity). Restricts osteoclastogenesis: together with NFE2L1; represses expression of DSPP during odontoblast differentiation (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions. [provided by RefSeq, Oct 2013]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P17676 [Direct mapping] CCAAT/enhancer-binding protein beta
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000779[condensed chromosome, centromeric region] GO:0000785[chromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000977[RNA polymerase II transcription regulatory region sequence-specific DNA binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000979[RNA polymerase II core promoter sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001541[ovarian follicle development] GO:0001889[liver development] GO:0001892[embryonic placenta development] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006351[DNA-templated transcription] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006366[transcription by RNA polymerase II] GO:0006953[acute-phase response] GO:0006954[inflammatory response] GO:0006955[immune response] GO:0007613[memory] GO:0010628[positive regulation of gene expression] GO:0016363[nuclear matrix] GO:0019900[kinase binding] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0031490[chromatin DNA binding] GO:0032496[response to lipopolysaccharide] GO:0032675[regulation of interleukin-6 production] GO:0032753[positive regulation of interleukin-4 production] GO:0033598[mammary gland epithelial cell proliferation] GO:0034976[response to endoplasmic reticulum stress] GO:0035035[histone acetyltransferase binding] GO:0035259[nuclear glucocorticoid receptor binding] GO:0036488[CHOP-C/EBP complex] GO:0042130[negative regulation of T cell proliferation] GO:0042742[defense response to bacterium] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0042826[histone deacetylase binding] GO:0043524[negative regulation of neuron apoptotic process] GO:0043565[sequence-specific DNA binding] GO:0044389[ubiquitin-like protein ligase binding] GO:0045444[fat cell differentiation] GO:0045595[regulation of cell differentiation] GO:0045600[positive regulation of fat cell differentiation] GO:0045669[positive regulation of osteoblast differentiation] GO:0045670[regulation of osteoclast differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046982[protein heterodimerization activity] GO:0050729[positive regulation of inflammatory response] GO:0050873[brown fat cell differentiation] GO:0060644[mammary gland epithelial cell differentiation] GO:0061515[myeloid cell development] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070059[intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress] GO:0070169[positive regulation of biomineral tissue development] GO:0071222[cellular response to lipopolysaccharide] GO:0071230[cellular response to amino acid stimulus] GO:0071347[cellular response to interleukin-1] GO:0071407[cellular response to organic cyclic compound] GO:0072574[hepatocyte proliferation] GO:0090575[RNA polymerase II transcription regulator complex] GO:0097421[liver regeneration] GO:0120162[positive regulation of cold-induced thermogenesis] GO:0140297[DNA-binding transcription factor binding] GO:0140467[integrated stress response signaling] GO:1901329[regulation of odontoblast differentiation] GO:1990440[positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990647[C/EBP complex] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000120[positive regulation of sodium-dependent phosphate transport] GO:2001198[regulation of dendritic cell differentiation]
The Human Protein Atlas project is funded
