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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
p12
Chromosome location (bp)
43526267 - 43557758
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Acts as a coactivator in the regulation of translation initiation of poly(A)-containing mRNAs. Its stimulatory activity on translation is mediated via its action on PABPC1. Competes with PAIP2 for binding to PABPC1. Its association with EIF4A and PABPC1 may potentiate contacts between mRNA termini. May also be involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Host-virus interaction, Translation regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene interacts with poly(A)-binding protein and with the cap-binding complex eIF4A. It is involved in translational initiation and protein biosynthesis. Overexpression of this gene in COS7 cells stimulates translation. Alternative splicing occurs at this locus and three transcript variants encoding three distinct isoforms have been identified. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q9H074 [Direct mapping] Polyadenylate-binding protein-interacting protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006413[translational initiation] GO:0006417[regulation of translation] GO:0006446[regulation of translational initiation] GO:0008494[translation activator activity] GO:0044794[positive regulation by host of viral process] GO:0048255[mRNA stabilization] GO:0070934[CRD-mediated mRNA stabilization] GO:0106002[mCRD-mediated mRNA stability complex] GO:1900152[negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:2000767[positive regulation of cytoplasmic translation]
Q9H074 [Direct mapping] Polyadenylate-binding protein-interacting protein 1
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SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006413[translational initiation] GO:0006417[regulation of translation] GO:0006446[regulation of translational initiation] GO:0008494[translation activator activity] GO:0044794[positive regulation by host of viral process] GO:0048255[mRNA stabilization] GO:0070934[CRD-mediated mRNA stabilization] GO:0106002[mCRD-mediated mRNA stability complex] GO:1900152[negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:2000767[positive regulation of cytoplasmic translation]
Q9H074 [Direct mapping] Polyadenylate-binding protein-interacting protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0003723[RNA binding] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006413[translational initiation] GO:0006417[regulation of translation] GO:0006446[regulation of translational initiation] GO:0008494[translation activator activity] GO:0044794[positive regulation by host of viral process] GO:0048255[mRNA stabilization] GO:0070934[CRD-mediated mRNA stabilization] GO:0106002[mCRD-mediated mRNA stability complex] GO:1900152[negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay] GO:2000767[positive regulation of cytoplasmic translation]
D6RJ02 [Direct mapping] Polyadenylate-binding protein-interacting protein 1
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SPOCTOPUS predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
D6RJF2 [Direct mapping] Polyadenylate-binding protein-interacting protein 1
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SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
D6RD97 [Direct mapping] Polyadenylate-binding protein-interacting protein 1
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SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
