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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
CD markers Disease related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
12
Cytoband
p13.2
Chromosome location (bp)
10116777 - 10130258
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Lectin that functions as a pattern recognizing receptor (PRR) specific for beta-1,3-linked and beta-1,6-linked glucans, which constitute cell wall constituents from pathogenic bacteria and fungi 1,2. Necessary for the TLR2-mediated inflammatory response and activation of NF-kappa-B: upon beta-glucan binding, recruits SYK via its ITAM motif and promotes a signaling cascade that activates some CARD domain-BCL10-MALT1 (CBM) signalosomes, leading to the activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines (By similarity). Enhances cytokine production in macrophages and dendritic cells (By similarity). Mediates production of reactive oxygen species in the cell (By similarity). Mediates phagocytosis of C.albicans conidia 3. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation. Induces phosphorylation of SCIMP after binding beta-glucans (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Receptor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Immunity, Inflammatory response, Innate immunity
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Lectin, Metal-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q9BXN2 [Direct mapping] C-type lectin domain family 7 member A
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CD markers DeepTMHMM predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Human disease related genes Immune system diseases Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0001775[cell activation] GO:0001872[(1->3)-beta-D-glucan binding] GO:0001878[response to yeast] GO:0001879[detection of yeast] GO:0002223[stimulatory C-type lectin receptor signaling pathway] GO:0002376[immune system process] GO:0002732[positive regulation of dendritic cell cytokine production] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005886[plasma membrane] GO:0006910[phagocytosis, recognition] GO:0006954[inflammatory response] GO:0008037[cell recognition] GO:0008284[positive regulation of cell population proliferation] GO:0009756[carbohydrate mediated signaling] GO:0009986[cell surface] GO:0010628[positive regulation of gene expression] GO:0016020[membrane] GO:0016046[detection of fungus] GO:0030246[carbohydrate binding] GO:0030335[positive regulation of cell migration] GO:0031334[positive regulation of protein-containing complex assembly] GO:0032491[detection of molecule of fungal origin] GO:0032729[positive regulation of interferon-gamma production] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032733[positive regulation of interleukin-10 production] GO:0032735[positive regulation of interleukin-12 production] GO:0032743[positive regulation of interleukin-2 production] GO:0032747[positive regulation of interleukin-23 production] GO:0032755[positive regulation of interleukin-6 production] GO:0032757[positive regulation of interleukin-8 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0032930[positive regulation of superoxide anion generation] GO:0038187[pattern recognition receptor activity] GO:0042110[T cell activation] GO:0042287[MHC protein binding] GO:0042832[defense response to protozoan] GO:0043122[regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043280[positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0045087[innate immune response] GO:0045429[positive regulation of nitric oxide biosynthetic process] GO:0046872[metal ion binding] GO:0050766[positive regulation of phagocytosis] GO:0050850[positive regulation of calcium-mediated signaling] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051251[positive regulation of lymphocyte activation] GO:0051712[positive regulation of killing of cells of another organism] GO:0060267[positive regulation of respiratory burst] GO:0061760[antifungal innate immune response] GO:0070884[regulation of calcineurin-NFAT signaling cascade] GO:0071226[cellular response to molecule of fungal origin] GO:0071639[positive regulation of monocyte chemotactic protein-1 production] GO:0090303[positive regulation of wound healing] GO:1900017[positive regulation of cytokine production involved in inflammatory response] GO:1903431[positive regulation of cell maturation] GO:2000318[positive regulation of T-helper 17 type immune response]
Q68D78 [Direct mapping] C-type lectin domain family 7 member A; C-type lectin domain family 7 member A isoform 2; Uncharacterized protein DKFZp686L24211; cDNA FLJ59887, moderately similar to Homo sapiens C-type lectin domain family 7, member A (CLEC7A), transcript variant 4, mRNA
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Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Human disease related genes Immune system diseases Other immune system diseases DeepTMHMM predicted membrane proteins
The Human Protein Atlas project is funded
