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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes Potential drug targets RAS pathway related proteins Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
7
Cytoband
q22.1
Chromosome location (bp)
100673567 - 100679174
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Transducer
Gene summary (Entrez)i
Useful information about the gene from Entrez
Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. This gene contains a trinucleotide (CCG) repeat length polymorphism in its 5' UTR. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P62879 [Direct mapping] Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
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Q6FHM2 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein; GNB2 protein; Guanine nucleotide binding protein (G protein), beta polypeptide 2, isoform CRA_a; cDNA FLJ77321, highly similar to Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2 (GNB2), mRNA
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Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Disease related genes Potential drug targets Human disease related genes Cardiovascular diseases Cardiac diseases Congenital malformations Congenital malformations of the nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P62879 [Direct mapping] Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Show all
Q6FHM2 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein; GNB2 protein; Guanine nucleotide binding protein (G protein), beta polypeptide 2, isoform CRA_a; cDNA FLJ77321, highly similar to Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2 (GNB2), mRNA
Show all
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Disease related genes Potential drug targets Human disease related genes Cardiovascular diseases Cardiac diseases Congenital malformations Congenital malformations of the nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
P62879 [Direct mapping] Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Show all
Q6FHM2 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein; GNB2 protein; Guanine nucleotide binding protein (G protein), beta polypeptide 2, isoform CRA_a; cDNA FLJ77321, highly similar to Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 2 (GNB2), mRNA
Show all
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Disease related genes Potential drug targets Human disease related genes Cardiovascular diseases Cardiac diseases Congenital malformations Congenital malformations of the nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
C9JZN1 [Direct mapping] Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Cardiovascular diseases Cardiac diseases Congenital malformations Congenital malformations of the nervous system Protein evidence (Ezkurdia et al 2014)
P62879 [Direct mapping] Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Show all
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Disease related genes Potential drug targets Human disease related genes Cardiovascular diseases Cardiac diseases Congenital malformations Congenital malformations of the nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
E7EP32 [Direct mapping] Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Cardiovascular diseases Cardiac diseases Congenital malformations Congenital malformations of the nervous system Protein evidence (Ezkurdia et al 2014)
P62879 [Direct mapping] Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Show all
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Disease related genes Potential drug targets Human disease related genes Cardiovascular diseases Cardiac diseases Congenital malformations Congenital malformations of the nervous system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
C9JIS1 [Direct mapping] Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Cardiovascular diseases Cardiac diseases Congenital malformations Congenital malformations of the nervous system Protein evidence (Ezkurdia et al 2014)
E7EP32 [Direct mapping] Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Cardiovascular diseases Cardiac diseases Congenital malformations Congenital malformations of the nervous system Protein evidence (Ezkurdia et al 2014)
C9JXA5 [Direct mapping] Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Cardiovascular diseases Cardiac diseases Congenital malformations Congenital malformations of the nervous system Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
