We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
15
Cytoband
q14
Chromosome location (bp)
38488103 - 38565575
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Functions as a calcium- and diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP 1,2,3,4. Activates the Erk/MAP kinase cascade 5. Regulates T-cell/B-cell development, homeostasis and differentiation by coupling T-lymphocyte/B-lymphocyte antigen receptors to Ras 6,7,8,9. Regulates NK cell cytotoxicity and ITAM-dependent cytokine production by activation of Ras-mediated ERK and JNK pathways 10. Functions in mast cell degranulation and cytokine secretion, regulating FcERI-evoked allergic responses. May also function in differentiation of other cell types 11....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Guanine-nucleotide releasing factor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Differentiation
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium, Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene is a member of a family of genes characterized by the presence of a Ras superfamily guanine nucleotide exchange factor (GEF) domain. It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the Erk/MAP kinase cascade and regulates T-cells and B-cells development, homeostasis and differentiation. Alternatively spliced transcript variants encoding different isoforms have been identified. Altered expression of the different isoforms of this protein may be a cause of susceptibility to systemic lupus erythematosus (SLE). [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
O95267 [Direct mapping] RAS guanyl-releasing protein 1
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Disease related genes Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139[Golgi membrane] GO:0001934[positive regulation of protein phosphorylation] GO:0002437[inflammatory response to antigenic stimulus] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005509[calcium ion binding] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0008270[zinc ion binding] GO:0008289[lipid binding] GO:0014066[regulation of phosphatidylinositol 3-kinase signaling] GO:0016020[membrane] GO:0019992[diacylglycerol binding] GO:0030101[natural killer cell activation] GO:0030154[cell differentiation] GO:0031210[phosphatidylcholine binding] GO:0032252[secretory granule localization] GO:0032725[positive regulation of granulocyte macrophage colony-stimulating factor production] GO:0032729[positive regulation of interferon-gamma production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0032816[positive regulation of natural killer cell activation] GO:0032825[positive regulation of natural killer cell differentiation] GO:0033089[positive regulation of T cell differentiation in thymus] GO:0042098[T cell proliferation] GO:0042100[B cell proliferation] GO:0042110[T cell activation] GO:0042113[B cell activation] GO:0042802[identical protein binding] GO:0043303[mast cell degranulation] GO:0043406[positive regulation of MAP kinase activity] GO:0043547[positive regulation of GTPase activity] GO:0045954[positive regulation of natural killer cell mediated cytotoxicity] GO:0046330[positive regulation of JNK cascade] GO:0046579[positive regulation of Ras protein signal transduction] GO:0046872[metal ion binding] GO:0047496[vesicle transport along microtubule] GO:0050790[regulation of catalytic activity] GO:0050896[response to stimulus] GO:0070372[regulation of ERK1 and ERK2 cascade] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0090630[activation of GTPase activity]
O95267 [Direct mapping] RAS guanyl-releasing protein 1
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Disease related genes Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139[Golgi membrane] GO:0001934[positive regulation of protein phosphorylation] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005509[calcium ion binding] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0008270[zinc ion binding] GO:0008289[lipid binding] GO:0016020[membrane] GO:0019992[diacylglycerol binding] GO:0030101[natural killer cell activation] GO:0030154[cell differentiation] GO:0031210[phosphatidylcholine binding] GO:0032725[positive regulation of granulocyte macrophage colony-stimulating factor production] GO:0032729[positive regulation of interferon-gamma production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0042098[T cell proliferation] GO:0042100[B cell proliferation] GO:0042110[T cell activation] GO:0042113[B cell activation] GO:0042802[identical protein binding] GO:0043406[positive regulation of MAP kinase activity] GO:0043547[positive regulation of GTPase activity] GO:0045954[positive regulation of natural killer cell mediated cytotoxicity] GO:0046330[positive regulation of JNK cascade] GO:0046579[positive regulation of Ras protein signal transduction] GO:0046872[metal ion binding] GO:0050790[regulation of catalytic activity] GO:0050896[response to stimulus] GO:0070372[regulation of ERK1 and ERK2 cascade] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0090630[activation of GTPase activity]
O95267 [Direct mapping] RAS guanyl-releasing protein 1
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Disease related genes Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139[Golgi membrane] GO:0001934[positive regulation of protein phosphorylation] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005509[calcium ion binding] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0008270[zinc ion binding] GO:0008289[lipid binding] GO:0016020[membrane] GO:0019992[diacylglycerol binding] GO:0030101[natural killer cell activation] GO:0030154[cell differentiation] GO:0031210[phosphatidylcholine binding] GO:0032725[positive regulation of granulocyte macrophage colony-stimulating factor production] GO:0032729[positive regulation of interferon-gamma production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0042098[T cell proliferation] GO:0042100[B cell proliferation] GO:0042110[T cell activation] GO:0042113[B cell activation] GO:0042802[identical protein binding] GO:0043406[positive regulation of MAP kinase activity] GO:0043547[positive regulation of GTPase activity] GO:0045954[positive regulation of natural killer cell mediated cytotoxicity] GO:0046330[positive regulation of JNK cascade] GO:0046579[positive regulation of Ras protein signal transduction] GO:0046872[metal ion binding] GO:0050790[regulation of catalytic activity] GO:0050896[response to stimulus] GO:0070372[regulation of ERK1 and ERK2 cascade] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0090630[activation of GTPase activity]
H0YN83 [Direct mapping] RAS guanyl-releasing protein 1
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005509[calcium ion binding] GO:0007264[small GTPase mediated signal transduction]
H0YMF3 [Direct mapping] RAS guanyl-releasing protein 1
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005509[calcium ion binding] GO:0007264[small GTPase mediated signal transduction]
O95267 [Direct mapping] RAS guanyl-releasing protein 1
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Disease related genes Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000139[Golgi membrane] GO:0001934[positive regulation of protein phosphorylation] GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005509[calcium ion binding] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005789[endoplasmic reticulum membrane] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007165[signal transduction] GO:0007264[small GTPase mediated signal transduction] GO:0007265[Ras protein signal transduction] GO:0008270[zinc ion binding] GO:0008289[lipid binding] GO:0016020[membrane] GO:0019992[diacylglycerol binding] GO:0030101[natural killer cell activation] GO:0030154[cell differentiation] GO:0031210[phosphatidylcholine binding] GO:0032725[positive regulation of granulocyte macrophage colony-stimulating factor production] GO:0032729[positive regulation of interferon-gamma production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0042098[T cell proliferation] GO:0042100[B cell proliferation] GO:0042110[T cell activation] GO:0042113[B cell activation] GO:0042802[identical protein binding] GO:0043406[positive regulation of MAP kinase activity] GO:0043547[positive regulation of GTPase activity] GO:0045954[positive regulation of natural killer cell mediated cytotoxicity] GO:0046330[positive regulation of JNK cascade] GO:0046579[positive regulation of Ras protein signal transduction] GO:0046872[metal ion binding] GO:0050790[regulation of catalytic activity] GO:0050896[response to stimulus] GO:0070372[regulation of ERK1 and ERK2 cascade] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0090630[activation of GTPase activity]
H0YKP8 [Direct mapping] RAS guanyl-releasing protein 1
Show all
DeepTMHMM predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
H0YNG8 [Direct mapping] RAS guanyl-releasing protein 1
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005509[calcium ion binding] GO:0007264[small GTPase mediated signal transduction]
H0YKM0 [Direct mapping] RAS guanyl-releasing protein 1
Show all
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005509[calcium ion binding] GO:0007264[small GTPase mediated signal transduction]
SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005509[calcium ion binding] GO:0007264[small GTPase mediated signal transduction]
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005509[calcium ion binding] GO:0007264[small GTPase mediated signal transduction]
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005509[calcium ion binding] GO:0007264[small GTPase mediated signal transduction]
THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Human disease related genes Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005085[guanyl-nucleotide exchange factor activity] GO:0005509[calcium ion binding] GO:0007264[small GTPase mediated signal transduction]
The Human Protein Atlas project is funded
