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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
q22.2
Chromosome location (bp)
112976702 - 113022195
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs 1,2,3,4,5,6. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP 7,8,9,10,11. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay 12. Plays a role in replication-dependent histone mRNA degradation 13. Has higher activity towards mRNAs that lack a poly(A) tail 14. Has no activity towards a cap structure lacking an RNA moiety 15. The presence of a N(6)-methyladenosine methylation at the second transcribed position of mRNAs (N(6),2'-O-dimethyladenosine cap; m6A(m)) provides resistance to DCP2-mediated decapping 16. Blocks autophagy in nutrient-rich conditions by repressing the expression of ATG-related genes through degradation of their transcripts 17....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hydrolase, RNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Nonsense-mediated mRNA decay
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Manganese, Metal-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a key component of an mRNA-decapping complex required for degradation of mRNAs, both in normal mRNA turnover, and in nonsense-mediated mRNA decay (NMD). It removes the 7-methyl guanine cap structure from mRNA, prior to its degradation from the 5' end. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000184[nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0000290[deadenylation-dependent decapping of nuclear-transcribed mRNA] GO:0000932[P-body] GO:0003723[RNA binding] GO:0004534[5'-3' exoribonuclease activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006402[mRNA catabolic process] GO:0016442[RISC complex] GO:0016787[hydrolase activity] GO:0016896[exoribonuclease activity, producing 5'-phosphomonoesters] GO:0030054[cell junction] GO:0030145[manganese ion binding] GO:0032211[negative regulation of telomere maintenance via telomerase] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0043488[regulation of mRNA stability] GO:0043928[exonucleolytic catabolism of deadenylated mRNA] GO:0046872[metal ion binding] GO:0050072[m7G(5')pppN diphosphatase activity] GO:0070034[telomerase RNA binding] GO:0071044[histone mRNA catabolic process] GO:0090503[RNA phosphodiester bond hydrolysis, exonucleolytic] GO:0140933[] GO:1904872[regulation of telomerase RNA localization to Cajal body]
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000184[nuclear-transcribed mRNA catabolic process, nonsense-mediated decay] GO:0000290[deadenylation-dependent decapping of nuclear-transcribed mRNA] GO:0000932[P-body] GO:0003723[RNA binding] GO:0004534[5'-3' exoribonuclease activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006402[mRNA catabolic process] GO:0016442[RISC complex] GO:0016787[hydrolase activity] GO:0016896[exoribonuclease activity, producing 5'-phosphomonoesters] GO:0030054[cell junction] GO:0030145[manganese ion binding] GO:0032211[negative regulation of telomere maintenance via telomerase] GO:0036464[cytoplasmic ribonucleoprotein granule] GO:0043488[regulation of mRNA stability] GO:0043928[exonucleolytic catabolism of deadenylated mRNA] GO:0046872[metal ion binding] GO:0050072[m7G(5')pppN diphosphatase activity] GO:0070034[telomerase RNA binding] GO:0071044[histone mRNA catabolic process] GO:0090503[RNA phosphodiester bond hydrolysis, exonucleolytic] GO:0140933[] GO:1904872[regulation of telomerase RNA localization to Cajal body]
The Human Protein Atlas project is funded
