GENERAL INFORMATIONi
Gene namei TRAF6
Synonyms RNF85
Gene descriptioni TNF receptor associated factor 6
Protein classi Enzymes
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 11
Cytoband p12
Chromosome location (bp) 36483769 - 36510272
Number of transcriptsi 2
Ensembl ENSG00000175104 (version 109)
Entrez gene 7189
HGNC HGNC:12036
UniProt Q9Y4K3 (UniProt - Evidence at protein level)
neXtProt NX_Q9Y4K3
GeneCards TRAF6
Antibodypedia TRAF6 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i E3 ubiquitin ligase that, together with UBE2N and UBE2V1, mediates the synthesis of 'Lys-63'-linked-polyubiquitin chains conjugated to proteins, such as ECSIT, IKBKG, IRAK1, AKT1 and AKT2 1, 2, 3, 4, 5. Also mediates ubiquitination of free/unanchored polyubiquitin chain that leads to MAP3K7 activation 6. Leads to the activation of NF-kappa-B and JUN 7, 8, 9. Seems to also play a role in dendritic cells (DCs) maturation and/or activation (By similarity). Represses c-Myb-mediated transactivation, in B-lymphocytes 10, 11. Adapter protein that seems to play a role in signal transduction initiated via TNF receptor, IL-1 receptor and IL-17 receptor 12, 13, 14. Regulates osteoclast differentiation by mediating the activation of adapter protein complex 1 (AP-1) and NF-kappa-B, in response to RANK-L stimulation (By similarity). Together with MAP3K8, mediates CD40 signals that activate ERK in B-cells and macrophages, and thus may play a role in the regulation of immunoglobulin production (By similarity). Participates also in the TCR signaling by ubiquitinating LAT 15, 16. show less
Molecular function (UniProt)i Transferase
Biological process (UniProt)i DNA damage, Immunity, Osteogenesis, Ubl conjugation pathway
Ligand (UniProt)i Metal-binding, Zinc
Gene summary (Entrez)i The protein encoded by this gene is a member of the TNF receptor associated factor (TRAF) protein family. TRAF proteins are associated with, and mediate signal transduction from, members of the TNF receptor superfamily. This protein has an amino terminal RING domain which is followed by four zinc-finger motifs, a central coiled-coil region and a highly conserved carboxyl terminal domain, known as the TRAF-C domain and mediates signaling from members of the TNF receptor superfamily as well as the Toll/IL-1 family. Signals from receptors such as CD40, TNFSF11/RANCE and IL-1 have been shown to be mediated by this protein. This protein also interacts with various protein kinases including IRAK1/IRAK, SRC and PKCzeta, which provides a link between distinct signaling pathways. This protein functions as a signal transducer in the NF-kappaB pathway that activates IkappaB kinase (IKK) in response to proinflammatory cytokines. The interaction of this protein with UBE2N/UBC13, and UBE2V1/UEV1A, which are ubiquitin conjugating enzymes catalyzing the formation of polyubiquitin chains, has been found to be required for IKK activation by this protein. This protein also interacts with the transforming growth factor (TGF) beta receptor complex and is required for Smad-independent activation of the JNK and p38 kinases. The protein encoded by this gene is a key molecule in antiviral innate and antigen-specific immune responses. [provided by RefSeq, Nov 2021] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
TRAF6-201
ENSP00000337853
ENST00000348124
Q9Y4K3
[Direct mapping] TNF receptor-associated factor 6
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000209 [protein polyubiquitination]
GO:0001503 [ossification]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002376 [immune system process]
GO:0002726 [positive regulation of T cell cytokine production]
GO:0002753 [cytoplasmic pattern recognition receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005811 [lipid droplet]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007165 [signal transduction]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007250 [activation of NF-kappaB-inducing kinase activity]
GO:0008270 [zinc ion binding]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0010008 [endosome membrane]
GO:0016567 [protein ubiquitination]
GO:0016740 [transferase activity]
GO:0019901 [protein kinase binding]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031435 [mitogen-activated protein kinase kinase kinase binding]
GO:0031624 [ubiquitin conjugating enzyme binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031996 [thioesterase binding]
GO:0032147 [activation of protein kinase activity]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0032813 [tumor necrosis factor receptor superfamily binding]
GO:0032991 [protein-containing complex]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0035631 [CD40 receptor complex]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042802 [identical protein binding]
GO:0042826 [histone deacetylase binding]
GO:0042981 [regulation of apoptotic process]
GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043422 [protein kinase B binding]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0045672 [positive regulation of osteoclast differentiation]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046330 [positive regulation of JNK cascade]
GO:0046872 [metal ion binding]
GO:0047485 [protein N-terminus binding]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048584 [positive regulation of response to stimulus]
GO:0050852 [T cell receptor signaling pathway]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051865 [protein autoubiquitination]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070498 [interleukin-1-mediated signaling pathway]
GO:0070534 [protein K63-linked ubiquitination]
GO:0070555 [response to interleukin-1]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071345 [cellular response to cytokine stimulus]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1904996 [positive regulation of leukocyte adhesion to vascular endothelial cell]
GO:2000679 [positive regulation of transcription regulatory region DNA binding]
Show all
 522 aa
59.6 kDa 		No 0
TRAF6-202
ENSP00000433623
ENST00000526995
Q9Y4K3
[Direct mapping] TNF receptor-associated factor 6
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000209 [protein polyubiquitination]
GO:0001503 [ossification]
GO:0001701 [in utero embryonic development]
GO:0001843 [neural tube closure]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002376 [immune system process]
GO:0002637 [regulation of immunoglobulin production]
GO:0002726 [positive regulation of T cell cytokine production]
GO:0002753 [cytoplasmic pattern recognition receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005164 [tumor necrosis factor receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005811 [lipid droplet]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005938 [cell cortex]
GO:0006955 [immune response]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007165 [signal transduction]
GO:0007249 [I-kappaB kinase/NF-kappaB signaling]
GO:0007250 [activation of NF-kappaB-inducing kinase activity]
GO:0008270 [zinc ion binding]
GO:0009887 [animal organ morphogenesis]
GO:0009898 [cytoplasmic side of plasma membrane]
GO:0010008 [endosome membrane]
GO:0016567 [protein ubiquitination]
GO:0016740 [transferase activity]
GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II]
GO:0019901 [protein kinase binding]
GO:0030316 [osteoclast differentiation]
GO:0031398 [positive regulation of protein ubiquitination]
GO:0031435 [mitogen-activated protein kinase kinase kinase binding]
GO:0031624 [ubiquitin conjugating enzyme binding]
GO:0031625 [ubiquitin protein ligase binding]
GO:0031663 [lipopolysaccharide-mediated signaling pathway]
GO:0031666 [positive regulation of lipopolysaccharide-mediated signaling pathway]
GO:0031996 [thioesterase binding]
GO:0032147 [activation of protein kinase activity]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0032743 [positive regulation of interleukin-2 production]
GO:0032755 [positive regulation of interleukin-6 production]
GO:0032813 [tumor necrosis factor receptor superfamily binding]
GO:0032991 [protein-containing complex]
GO:0033209 [tumor necrosis factor-mediated signaling pathway]
GO:0035556 [intracellular signal transduction]
GO:0035631 [CD40 receptor complex]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042088 [T-helper 1 type immune response]
GO:0042102 [positive regulation of T cell proliferation]
GO:0042475 [odontogenesis of dentin-containing tooth]
GO:0042802 [identical protein binding]
GO:0042826 [histone deacetylase binding]
GO:0042981 [regulation of apoptotic process]
GO:0043011 [myeloid dendritic cell differentiation]
GO:0043122 [regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043422 [protein kinase B binding]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0045453 [bone resorption]
GO:0045672 [positive regulation of osteoclast differentiation]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046330 [positive regulation of JNK cascade]
GO:0046849 [bone remodeling]
GO:0046872 [metal ion binding]
GO:0047485 [protein N-terminus binding]
GO:0048468 [cell development]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048584 [positive regulation of response to stimulus]
GO:0050852 [T cell receptor signaling pathway]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051865 [protein autoubiquitination]
GO:0061630 [ubiquitin protein ligase activity]
GO:0070498 [interleukin-1-mediated signaling pathway]
GO:0070534 [protein K63-linked ubiquitination]
GO:0070555 [response to interleukin-1]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071345 [cellular response to cytokine stimulus]
GO:0097400 [interleukin-17-mediated signaling pathway]
GO:1901224 [positive regulation of NIK/NF-kappaB signaling]
GO:1904996 [positive regulation of leukocyte adhesion to vascular endothelial cell]
GO:2000679 [positive regulation of transcription regulatory region DNA binding]
Show all
 522 aa
59.6 kDa 		No 0

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