GENERAL INFORMATIONi
Gene namei DDIT3
Synonyms CHOP, CHOP10, GADD153
Gene descriptioni DNA damage inducible transcript 3
Protein classi Cancer-related genes
Disease related genes
Human disease related genes
Transcription factors
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 12
Cytoband q13.3
Chromosome location (bp) 57516588 - 57521737
Number of transcriptsi 6
Ensembl ENSG00000175197 (version 109)
Entrez gene 1649
HGNC HGNC:2726
UniProt P35638 (UniProt - Evidence at protein level)
neXtProt NX_P35638
GeneCards DDIT3
Antibodypedia DDIT3 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Multifunctional transcription factor in endoplasmic reticulum (ER) stress response 1, 2, 3. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress 4, 5. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes (By similarity). Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes (By similarity). Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L 6, 7, 8, 9. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG) 10, 11, 12. Together with ATF4, mediates ER-mediated cell death by promoting expression of genes involved in cellular amino acid metabolic processes, mRNA translation and the unfolded protein response (UPR) in response to ER stress (By similarity). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity 13. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response (By similarity). Acts as a major regulator of postnatal neovascularization through regulation of endothelial nitric oxide synthase (NOS3)-related signaling (By similarity). show less
Molecular function (UniProt)i Activator, DNA-binding, Repressor
Biological process (UniProt)i Apoptosis, Cell cycle, Growth arrest, Stress response, Transcription, Transcription regulation, Unfolded protein response, Wnt signaling pathway
Gene summary (Entrez)i This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
DDIT3-201
ENSP00000340671
ENST00000346473
P35638
[Direct mapping] DNA damage-inducible transcript 3 protein
Show all
Q53YD1
[Target identity:100%; Query identity:100%] DNA damage-inducible transcript 3 protein
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of soft tissues and bone
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001955 [blood vessel maturation]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005770 [late endosome]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006983 [ER overload response]
GO:0006986 [response to unfolded protein]
GO:0007049 [cell cycle]
GO:0007605 [sensory perception of sound]
GO:0008140 [cAMP response element binding protein binding]
GO:0009611 [response to wounding]
GO:0009948 [anterior/posterior axis specification]
GO:0010467 [gene expression]
GO:0010506 [regulation of autophagy]
GO:0016055 [Wnt signaling pathway]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032700 [negative regulation of interleukin-17 production]
GO:0032713 [negative regulation of interleukin-4 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032792 [negative regulation of CREB transcription factor activity]
GO:0032993 [protein-DNA complex]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0036119 [response to platelet-derived growth factor]
GO:0036488 [CHOP-C/EBP complex]
GO:0036499 [PERK-mediated unfolded protein response]
GO:0036500 [ATF6-mediated unfolded protein response]
GO:0042594 [response to starvation]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043392 [negative regulation of DNA binding]
GO:0043433 [negative regulation of DNA-binding transcription factor activity]
GO:0043522 [leucine zipper domain binding]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0045454 [cell redox homeostasis]
GO:0045599 [negative regulation of fat cell differentiation]
GO:0045662 [negative regulation of myoblast differentiation]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046982 [protein heterodimerization activity]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051726 [regulation of cell cycle]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0060840 [artery development]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0072655 [establishment of protein localization to mitochondrion]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:0140416 [transcription regulator inhibitor activity]
GO:0140467 [integrated stress response signaling]
GO:1901216 [positive regulation of neuron death]
GO:1902237 [positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1903026 [negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding]
GO:1904738 [vascular associated smooth muscle cell migration]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:1990442 [intrinsic apoptotic signaling pathway in response to nitrosative stress]
GO:1990617 [CHOP-ATF4 complex]
GO:1990622 [CHOP-ATF3 complex]
GO:1990874 [vascular associated smooth muscle cell proliferation]
GO:2000016 [negative regulation of determination of dorsal identity]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 169 aa
19.2 kDa 		No 0
DDIT3-202
ENSP00000447188
ENST00000547303
P35638
[Direct mapping] DNA damage-inducible transcript 3 protein
Show all
Q53YD1
[Target identity:100%; Query identity:100%] DNA damage-inducible transcript 3 protein
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of soft tissues and bone
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006983 [ER overload response]
GO:0006986 [response to unfolded protein]
GO:0007049 [cell cycle]
GO:0008140 [cAMP response element binding protein binding]
GO:0009948 [anterior/posterior axis specification]
GO:0010506 [regulation of autophagy]
GO:0016055 [Wnt signaling pathway]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032700 [negative regulation of interleukin-17 production]
GO:0032713 [negative regulation of interleukin-4 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032792 [negative regulation of CREB transcription factor activity]
GO:0032993 [protein-DNA complex]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0036488 [CHOP-C/EBP complex]
GO:0036499 [PERK-mediated unfolded protein response]
GO:0036500 [ATF6-mediated unfolded protein response]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043433 [negative regulation of DNA-binding transcription factor activity]
GO:0043522 [leucine zipper domain binding]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0045454 [cell redox homeostasis]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046982 [protein heterodimerization activity]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051726 [regulation of cell cycle]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:0140416 [transcription regulator inhibitor activity]
GO:0140467 [integrated stress response signaling]
GO:1902237 [positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1903026 [negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:1990617 [CHOP-ATF4 complex]
GO:1990622 [CHOP-ATF3 complex]
GO:2000016 [negative regulation of determination of dorsal identity]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 169 aa
19.2 kDa 		No 0
DDIT3-203
ENSP00000447503
ENST00000547526
F8W133
[Direct mapping] DDIT3 upstream open reading frame protein
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Human disease related genes
   Cancers
   Cancers of soft tissues and bone
Show all
GO:0003677 [DNA binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
Show all
 145 aa
16 kDa 		No 0
DDIT3-204
ENSP00000448665
ENST00000551116
P35638
[Direct mapping] DNA damage-inducible transcript 3 protein
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of soft tissues and bone
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006983 [ER overload response]
GO:0006986 [response to unfolded protein]
GO:0007049 [cell cycle]
GO:0008140 [cAMP response element binding protein binding]
GO:0009948 [anterior/posterior axis specification]
GO:0010506 [regulation of autophagy]
GO:0016055 [Wnt signaling pathway]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032700 [negative regulation of interleukin-17 production]
GO:0032713 [negative regulation of interleukin-4 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032792 [negative regulation of CREB transcription factor activity]
GO:0032993 [protein-DNA complex]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0036488 [CHOP-C/EBP complex]
GO:0036499 [PERK-mediated unfolded protein response]
GO:0036500 [ATF6-mediated unfolded protein response]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043433 [negative regulation of DNA-binding transcription factor activity]
GO:0043522 [leucine zipper domain binding]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0045454 [cell redox homeostasis]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046982 [protein heterodimerization activity]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051726 [regulation of cell cycle]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:0140416 [transcription regulator inhibitor activity]
GO:0140467 [integrated stress response signaling]
GO:1902237 [positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1903026 [negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:1990617 [CHOP-ATF4 complex]
GO:1990622 [CHOP-ATF3 complex]
GO:2000016 [negative regulation of determination of dorsal identity]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 192 aa
21.7 kDa 		No 0
DDIT3-205
ENSP00000447803
ENST00000552740
P35638
[Direct mapping] DNA damage-inducible transcript 3 protein
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of soft tissues and bone
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006983 [ER overload response]
GO:0006986 [response to unfolded protein]
GO:0007049 [cell cycle]
GO:0008140 [cAMP response element binding protein binding]
GO:0009948 [anterior/posterior axis specification]
GO:0010506 [regulation of autophagy]
GO:0016055 [Wnt signaling pathway]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032700 [negative regulation of interleukin-17 production]
GO:0032713 [negative regulation of interleukin-4 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032792 [negative regulation of CREB transcription factor activity]
GO:0032993 [protein-DNA complex]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0036488 [CHOP-C/EBP complex]
GO:0036499 [PERK-mediated unfolded protein response]
GO:0036500 [ATF6-mediated unfolded protein response]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043433 [negative regulation of DNA-binding transcription factor activity]
GO:0043522 [leucine zipper domain binding]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0045454 [cell redox homeostasis]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046982 [protein heterodimerization activity]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051726 [regulation of cell cycle]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:0140416 [transcription regulator inhibitor activity]
GO:0140467 [integrated stress response signaling]
GO:1902237 [positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1903026 [negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:1990617 [CHOP-ATF4 complex]
GO:1990622 [CHOP-ATF3 complex]
GO:2000016 [negative regulation of determination of dorsal identity]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 192 aa
21.7 kDa 		No 0
DDIT3-206
ENSP00000494844
ENST00000623876
P35638
[Direct mapping] DNA damage-inducible transcript 3 protein
Show all
Q53YD1
[Target identity:100%; Query identity:100%] DNA damage-inducible transcript 3 protein
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Transcription factors
   Basic domains
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Human disease related genes
   Cancers
   Cancers of soft tissues and bone
Mapped to neXtProt
   neXtProt - Evidence at protein level
Show all
GO:0000122 [negative regulation of transcription by RNA polymerase II]
GO:0000785 [chromatin]
GO:0000976 [transcription cis-regulatory region binding]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0003677 [DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006357 [regulation of transcription by RNA polymerase II]
GO:0006915 [apoptotic process]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0006983 [ER overload response]
GO:0006986 [response to unfolded protein]
GO:0007049 [cell cycle]
GO:0008140 [cAMP response element binding protein binding]
GO:0009948 [anterior/posterior axis specification]
GO:0010506 [regulation of autophagy]
GO:0016055 [Wnt signaling pathway]
GO:0030968 [endoplasmic reticulum unfolded protein response]
GO:0032088 [negative regulation of NF-kappaB transcription factor activity]
GO:0032689 [negative regulation of interferon-gamma production]
GO:0032700 [negative regulation of interleukin-17 production]
GO:0032713 [negative regulation of interleukin-4 production]
GO:0032757 [positive regulation of interleukin-8 production]
GO:0032792 [negative regulation of CREB transcription factor activity]
GO:0032993 [protein-DNA complex]
GO:0034976 [response to endoplasmic reticulum stress]
GO:0036488 [CHOP-C/EBP complex]
GO:0036499 [PERK-mediated unfolded protein response]
GO:0036500 [ATF6-mediated unfolded protein response]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043161 [proteasome-mediated ubiquitin-dependent protein catabolic process]
GO:0043433 [negative regulation of DNA-binding transcription factor activity]
GO:0043522 [leucine zipper domain binding]
GO:0043525 [positive regulation of neuron apoptotic process]
GO:0043618 [regulation of transcription from RNA polymerase II promoter in response to stress]
GO:0045454 [cell redox homeostasis]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046982 [protein heterodimerization activity]
GO:0051091 [positive regulation of DNA-binding transcription factor activity]
GO:0051726 [regulation of cell cycle]
GO:0051898 [negative regulation of protein kinase B signaling]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0070059 [intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0090575 [RNA polymerase II transcription regulator complex]
GO:0120163 [negative regulation of cold-induced thermogenesis]
GO:0140416 [transcription regulator inhibitor activity]
GO:0140467 [integrated stress response signaling]
GO:1902237 [positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway]
GO:1903026 [negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding]
GO:1990440 [positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress]
GO:1990617 [CHOP-ATF4 complex]
GO:1990622 [CHOP-ATF3 complex]
GO:2000016 [negative regulation of determination of dorsal identity]
GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway]
Show all
 169 aa
19.2 kDa 		No 0

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