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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Human disease related genes Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
18
Cytoband
p11.21
Chromosome location (bp)
12785478 - 12929643
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Non-receptor type tyrosine-specific phosphatase that dephosphorylates receptor protein tyrosine kinases including INSR, EGFR, CSF1R, PDGFR. Also dephosphorylates non-receptor protein tyrosine kinases like JAK1, JAK2, JAK3, Src family kinases, STAT1, STAT3 and STAT6 either in the nucleus or the cytoplasm. Negatively regulates numerous signaling pathways and biological processes like hematopoiesis, inflammatory response, cell proliferation and differentiation, and glucose homeostasis. Plays a multifaceted and important role in the development of the immune system. Functions in T-cell receptor signaling through dephosphorylation of FYN and LCK to control T-cells differentiation and activation. Dephosphorylates CSF1R, negatively regulating its downstream signaling and macrophage differentiation. Negatively regulates cytokine (IL2/interleukin-2 and interferon)-mediated signaling through dephosphorylation of the cytoplasmic kinases JAK1, JAK3 and their substrate STAT1, that propagate signaling downstream of the cytokine receptors. Also regulates the IL6/interleukin-6 and IL4/interleukin-4 cytokine signaling through dephosphorylation of STAT3 and STAT6 respectively. In addition to the immune system, it is involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth. Activated by the integrin ITGA1/ITGB1, it dephosphorylates EGFR and negatively regulates EGF signaling. Dephosphorylates PDGFRB and negatively regulates platelet-derived growth factor receptor-beta signaling pathway and therefore cell proliferation. Negatively regulates tumor necrosis factor-mediated signaling downstream via MAPK through SRC dephosphorylation. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of the hepatocyte growth factor receptor MET. Also plays an important role in glucose homeostasis. For instance, negatively regulates the insulin receptor signaling pathway through the dephosphorylation of INSR and control gluconeogenesis and liver glucose production through negative regulation of the IL6 signaling pathways. May also bind DNA....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hydrolase, Protein phosphatase
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported. [provided by RefSeq, May 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P17706 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 2
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A8K3N4 [Target identity:100%; Query identity:100%] Tyrosine-protein phosphatase non-receptor type
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Enzymes ENZYME proteins Hydrolases Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Diabetes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004721[phosphoprotein phosphatase activity] GO:0004725[protein tyrosine phosphatase activity] GO:0004726[non-membrane spanning protein tyrosine phosphatase activity] GO:0005178[integrin binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005793[endoplasmic reticulum-Golgi intermediate compartment] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006470[protein dephosphorylation] GO:0008285[negative regulation of cell population proliferation] GO:0008286[insulin receptor signaling pathway] GO:0010804[negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0010888[negative regulation of lipid storage] GO:0016020[membrane] GO:0016311[dephosphorylation] GO:0016787[hydrolase activity] GO:0016791[phosphatase activity] GO:0019901[protein kinase binding] GO:0019905[syntaxin binding] GO:0030183[B cell differentiation] GO:0030217[T cell differentiation] GO:0030218[erythrocyte differentiation] GO:0030971[receptor tyrosine kinase binding] GO:0035335[peptidyl-tyrosine dephosphorylation] GO:0042059[negative regulation of epidermal growth factor receptor signaling pathway] GO:0042532[negative regulation of tyrosine phosphorylation of STAT protein] GO:0042593[glucose homeostasis] GO:0045650[negative regulation of macrophage differentiation] GO:0045722[positive regulation of gluconeogenesis] GO:0046426[negative regulation of receptor signaling pathway via JAK-STAT] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0050728[negative regulation of inflammatory response] GO:0050860[negative regulation of T cell receptor signaling pathway] GO:0050922[negative regulation of chemotaxis] GO:0060334[regulation of type II interferon-mediated signaling pathway] GO:0060336[negative regulation of interferon-gamma-mediated signaling pathway] GO:0060339[negative regulation of type I interferon-mediated signaling pathway] GO:0070104[negative regulation of interleukin-6-mediated signaling pathway] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:1902202[regulation of hepatocyte growth factor receptor signaling pathway] GO:1902206[negative regulation of interleukin-2-mediated signaling pathway] GO:1902215[negative regulation of interleukin-4-mediated signaling pathway] GO:1902227[negative regulation of macrophage colony-stimulating factor signaling pathway] GO:1902233[negative regulation of positive thymic T cell selection] GO:2000587[negative regulation of platelet-derived growth factor receptor-beta signaling pathway]
P17706 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 2
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Enzymes ENZYME proteins Hydrolases Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Diabetes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004721[phosphoprotein phosphatase activity] GO:0004725[protein tyrosine phosphatase activity] GO:0004726[non-membrane spanning protein tyrosine phosphatase activity] GO:0005178[integrin binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005793[endoplasmic reticulum-Golgi intermediate compartment] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006470[protein dephosphorylation] GO:0008285[negative regulation of cell population proliferation] GO:0008286[insulin receptor signaling pathway] GO:0010804[negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0010888[negative regulation of lipid storage] GO:0016020[membrane] GO:0016311[dephosphorylation] GO:0016787[hydrolase activity] GO:0016791[phosphatase activity] GO:0019901[protein kinase binding] GO:0019905[syntaxin binding] GO:0030183[B cell differentiation] GO:0030217[T cell differentiation] GO:0030218[erythrocyte differentiation] GO:0030971[receptor tyrosine kinase binding] GO:0035335[peptidyl-tyrosine dephosphorylation] GO:0042059[negative regulation of epidermal growth factor receptor signaling pathway] GO:0042532[negative regulation of tyrosine phosphorylation of STAT protein] GO:0042593[glucose homeostasis] GO:0045650[negative regulation of macrophage differentiation] GO:0045722[positive regulation of gluconeogenesis] GO:0046426[negative regulation of receptor signaling pathway via JAK-STAT] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0050728[negative regulation of inflammatory response] GO:0050860[negative regulation of T cell receptor signaling pathway] GO:0050922[negative regulation of chemotaxis] GO:0060334[regulation of type II interferon-mediated signaling pathway] GO:0060336[negative regulation of interferon-gamma-mediated signaling pathway] GO:0060339[negative regulation of type I interferon-mediated signaling pathway] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:1902202[regulation of hepatocyte growth factor receptor signaling pathway] GO:1902206[negative regulation of interleukin-2-mediated signaling pathway] GO:1902227[negative regulation of macrophage colony-stimulating factor signaling pathway] GO:1902233[negative regulation of positive thymic T cell selection] GO:2000587[negative regulation of platelet-derived growth factor receptor-beta signaling pathway]
K7EIE9 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Diabetes Protein evidence (Ezkurdia et al 2014)
K7ENP9 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Diabetes Protein evidence (Ezkurdia et al 2014)
P17706 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 2
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Enzymes ENZYME proteins Hydrolases Transporters Accessory Factors Involved in Transport SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Diabetes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0004721[phosphoprotein phosphatase activity] GO:0004725[protein tyrosine phosphatase activity] GO:0004726[non-membrane spanning protein tyrosine phosphatase activity] GO:0005178[integrin binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005793[endoplasmic reticulum-Golgi intermediate compartment] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006470[protein dephosphorylation] GO:0008285[negative regulation of cell population proliferation] GO:0008286[insulin receptor signaling pathway] GO:0010804[negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0010888[negative regulation of lipid storage] GO:0016020[membrane] GO:0016311[dephosphorylation] GO:0016787[hydrolase activity] GO:0016791[phosphatase activity] GO:0019901[protein kinase binding] GO:0019905[syntaxin binding] GO:0030183[B cell differentiation] GO:0030217[T cell differentiation] GO:0030218[erythrocyte differentiation] GO:0030971[receptor tyrosine kinase binding] GO:0035335[peptidyl-tyrosine dephosphorylation] GO:0042059[negative regulation of epidermal growth factor receptor signaling pathway] GO:0042532[negative regulation of tyrosine phosphorylation of STAT protein] GO:0042593[glucose homeostasis] GO:0045650[negative regulation of macrophage differentiation] GO:0045722[positive regulation of gluconeogenesis] GO:0046426[negative regulation of receptor signaling pathway via JAK-STAT] GO:0046627[negative regulation of insulin receptor signaling pathway] GO:0050728[negative regulation of inflammatory response] GO:0050860[negative regulation of T cell receptor signaling pathway] GO:0050922[negative regulation of chemotaxis] GO:0060334[regulation of type II interferon-mediated signaling pathway] GO:0060336[negative regulation of interferon-gamma-mediated signaling pathway] GO:0060339[negative regulation of type I interferon-mediated signaling pathway] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:1902202[regulation of hepatocyte growth factor receptor signaling pathway] GO:1902206[negative regulation of interleukin-2-mediated signaling pathway] GO:1902227[negative regulation of macrophage colony-stimulating factor signaling pathway] GO:1902233[negative regulation of positive thymic T cell selection] GO:2000587[negative regulation of platelet-derived growth factor receptor-beta signaling pathway]
K7EIY0 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Diabetes Protein evidence (Ezkurdia et al 2014)
K7ELS9 [Direct mapping] Tyrosine-protein phosphatase non-receptor type 2
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Endocrine and metabolic diseases Diabetes Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
