GENERAL INFORMATIONi
Gene namei SMAD2
Synonyms JV18-1, MADH2, MADR2
Gene descriptioni SMAD family member 2
Protein classi Cancer-related genes
Disease related genes
Human disease related genes
Plasma proteins
Transcription factors
Predicted locationi Membrane, Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 18
Cytoband q21.1
Chromosome location (bp) 47808957 - 47931146
Number of transcriptsi 10
Ensembl ENSG00000175387 (version 109)
Entrez gene 4087
HGNC HGNC:6768
UniProt Q15796 (UniProt - Evidence at protein level)
neXtProt NX_Q15796
GeneCards SMAD2
Antibodypedia SMAD2 antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. Promotes TGFB1-mediated transcription of odontoblastic differentiation genes in dental papilla cells (By similarity). Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. May act as a tumor suppressor in colorectal carcinoma 1. show less
Molecular function (UniProt)i DNA-binding
Biological process (UniProt)i Transcription, Transcription regulation
Ligand (UniProt)i Metal-binding, Zinc
Gene summary (Entrez)i The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
SMAD2-201
ENSP00000262160
ENST00000262160
Q15796
[Direct mapping] Mothers against decapentaplegic homolog 2
Show all
Q53XR6
[Target identity:100%; Query identity:100%] Mothers against decapentaplegic homolog
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Disease related genes
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the circulatory system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0000987 [cis-regulatory region sequence-specific DNA binding]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001657 [ureteric bud development]
GO:0001701 [in utero embryonic development]
GO:0001706 [endoderm formation]
GO:0001707 [mesoderm formation]
GO:0003180 [aortic valve morphogenesis]
GO:0003184 [pulmonary valve morphogenesis]
GO:0003203 [endocardial cushion morphogenesis]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [DNA-templated transcription]
GO:0006355 [regulation of DNA-templated transcription]
GO:0006468 [protein phosphorylation]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007182 [common-partner SMAD protein phosphorylation]
GO:0007183 [SMAD protein complex assembly]
GO:0007352 [zygotic specification of dorsal/ventral axis]
GO:0007369 [gastrulation]
GO:0007389 [pattern specification process]
GO:0007492 [endoderm development]
GO:0007507 [heart development]
GO:0008285 [negative regulation of cell population proliferation]
GO:0009653 [anatomical structure morphogenesis]
GO:0009749 [response to glucose]
GO:0009791 [post-embryonic development]
GO:0009880 [embryonic pattern specification]
GO:0009952 [anterior/posterior pattern specification]
GO:0010628 [positive regulation of gene expression]
GO:0010629 [negative regulation of gene expression]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway]
GO:0019902 [phosphatase binding]
GO:0023019 [signal transduction involved in regulation of gene expression]
GO:0030073 [insulin secretion]
GO:0030154 [cell differentiation]
GO:0030324 [lung development]
GO:0030325 [adrenal gland development]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0031016 [pancreas development]
GO:0031053 [primary miRNA processing]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032444 [activin responsive factor complex]
GO:0032924 [activin receptor signaling pathway]
GO:0032991 [protein-containing complex]
GO:0034713 [type I transforming growth factor beta receptor binding]
GO:0035265 [organ growth]
GO:0035556 [intracellular signal transduction]
GO:0038092 [nodal signaling pathway]
GO:0042060 [wound healing]
GO:0042802 [identical protein binding]
GO:0045165 [cell fate commitment]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046332 [SMAD binding]
GO:0046872 [metal ion binding]
GO:0048156 [tau protein binding]
GO:0048340 [paraxial mesoderm morphogenesis]
GO:0048589 [developmental growth]
GO:0048617 [embryonic foregut morphogenesis]
GO:0048701 [embryonic cranial skeleton morphogenesis]
GO:0051098 [regulation of binding]
GO:0060039 [pericardium development]
GO:0060395 [SMAD protein signal transduction]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0062009 [secondary palate development]
GO:0070410 [co-SMAD binding]
GO:0070411 [I-SMAD binding]
GO:0070412 [R-SMAD binding]
GO:0070723 [response to cholesterol]
GO:0071141 [SMAD protein complex]
GO:0071142 [homomeric SMAD protein complex]
GO:0071144 [heteromeric SMAD protein complex]
GO:0097718 [disordered domain specific binding]
GO:0140297 [DNA-binding transcription factor binding]
GO:1900224 [positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry]
Show all
 467 aa
52.3 kDa 		No 0
SMAD2-202
ENSP00000349282
ENST00000356825
Q15796
[Direct mapping] Mothers against decapentaplegic homolog 2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Disease related genes
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the circulatory system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0000987 [cis-regulatory region sequence-specific DNA binding]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001707 [mesoderm formation]
GO:0003180 [aortic valve morphogenesis]
GO:0003184 [pulmonary valve morphogenesis]
GO:0003203 [endocardial cushion morphogenesis]
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [DNA-templated transcription]
GO:0006355 [regulation of DNA-templated transcription]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007182 [common-partner SMAD protein phosphorylation]
GO:0007183 [SMAD protein complex assembly]
GO:0007352 [zygotic specification of dorsal/ventral axis]
GO:0007369 [gastrulation]
GO:0009653 [anatomical structure morphogenesis]
GO:0009952 [anterior/posterior pattern specification]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway]
GO:0019902 [phosphatase binding]
GO:0030154 [cell differentiation]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0031053 [primary miRNA processing]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032444 [activin responsive factor complex]
GO:0032924 [activin receptor signaling pathway]
GO:0032991 [protein-containing complex]
GO:0034713 [type I transforming growth factor beta receptor binding]
GO:0035556 [intracellular signal transduction]
GO:0038092 [nodal signaling pathway]
GO:0045165 [cell fate commitment]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046332 [SMAD binding]
GO:0046872 [metal ion binding]
GO:0048156 [tau protein binding]
GO:0048340 [paraxial mesoderm morphogenesis]
GO:0051098 [regulation of binding]
GO:0060395 [SMAD protein signal transduction]
GO:0062009 [secondary palate development]
GO:0070410 [co-SMAD binding]
GO:0070411 [I-SMAD binding]
GO:0070412 [R-SMAD binding]
GO:0070723 [response to cholesterol]
GO:0071141 [SMAD protein complex]
GO:0071142 [homomeric SMAD protein complex]
GO:0071144 [heteromeric SMAD protein complex]
GO:0097718 [disordered domain specific binding]
GO:0140297 [DNA-binding transcription factor binding]
GO:1900224 [positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry]
Show all
 437 aa
49 kDa 		No 0
SMAD2-203
ENSP00000384449
ENST00000402690
Q15796
[Direct mapping] Mothers against decapentaplegic homolog 2
Show all
Q53XR6
[Target identity:100%; Query identity:100%] Mothers against decapentaplegic homolog
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Disease related genes
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the circulatory system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0000987 [cis-regulatory region sequence-specific DNA binding]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001707 [mesoderm formation]
GO:0003180 [aortic valve morphogenesis]
GO:0003184 [pulmonary valve morphogenesis]
GO:0003203 [endocardial cushion morphogenesis]
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [DNA-templated transcription]
GO:0006355 [regulation of DNA-templated transcription]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007182 [common-partner SMAD protein phosphorylation]
GO:0007183 [SMAD protein complex assembly]
GO:0007352 [zygotic specification of dorsal/ventral axis]
GO:0007369 [gastrulation]
GO:0009653 [anatomical structure morphogenesis]
GO:0009952 [anterior/posterior pattern specification]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway]
GO:0019902 [phosphatase binding]
GO:0030154 [cell differentiation]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0031053 [primary miRNA processing]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032444 [activin responsive factor complex]
GO:0032924 [activin receptor signaling pathway]
GO:0032991 [protein-containing complex]
GO:0034713 [type I transforming growth factor beta receptor binding]
GO:0035556 [intracellular signal transduction]
GO:0038092 [nodal signaling pathway]
GO:0045165 [cell fate commitment]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046332 [SMAD binding]
GO:0046872 [metal ion binding]
GO:0048156 [tau protein binding]
GO:0048340 [paraxial mesoderm morphogenesis]
GO:0051098 [regulation of binding]
GO:0060395 [SMAD protein signal transduction]
GO:0061629 [RNA polymerase II-specific DNA-binding transcription factor binding]
GO:0062009 [secondary palate development]
GO:0070410 [co-SMAD binding]
GO:0070411 [I-SMAD binding]
GO:0070412 [R-SMAD binding]
GO:0070723 [response to cholesterol]
GO:0071141 [SMAD protein complex]
GO:0071142 [homomeric SMAD protein complex]
GO:0071144 [heteromeric SMAD protein complex]
GO:0097718 [disordered domain specific binding]
GO:0140297 [DNA-binding transcription factor binding]
GO:1900224 [positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry]
Show all
 467 aa
52.3 kDa 		No 0
SMAD2-204
ENSP00000468732
ENST00000585978
K7ESI8
[Direct mapping] Mothers against decapentaplegic homolog 2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the circulatory system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0006355 [regulation of DNA-templated transcription]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
Show all
 108 aa
11.7 kDa 		No 0
SMAD2-205
ENSP00000466193
ENST00000586040
Q15796
[Direct mapping] Mothers against decapentaplegic homolog 2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Transcription factors
   beta-Hairpin exposed by an alpha/beta-scaffold
Cancer-related genes
   Candidate cancer biomarkers
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Disease related genes
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the circulatory system
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785 [chromatin]
GO:0000978 [RNA polymerase II cis-regulatory region sequence-specific DNA binding]
GO:0000981 [DNA-binding transcription factor activity, RNA polymerase II-specific]
GO:0000987 [cis-regulatory region sequence-specific DNA binding]
GO:0001228 [DNA-binding transcription activator activity, RNA polymerase II-specific]
GO:0001707 [mesoderm formation]
GO:0003180 [aortic valve morphogenesis]
GO:0003184 [pulmonary valve morphogenesis]
GO:0003203 [endocardial cushion morphogenesis]
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [DNA-binding transcription factor activity]
GO:0005160 [transforming growth factor beta receptor binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [DNA-templated transcription]
GO:0006355 [regulation of DNA-templated transcription]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007182 [common-partner SMAD protein phosphorylation]
GO:0007183 [SMAD protein complex assembly]
GO:0007352 [zygotic specification of dorsal/ventral axis]
GO:0007369 [gastrulation]
GO:0009653 [anatomical structure morphogenesis]
GO:0009952 [anterior/posterior pattern specification]
GO:0010718 [positive regulation of epithelial to mesenchymal transition]
GO:0017015 [regulation of transforming growth factor beta receptor signaling pathway]
GO:0019902 [phosphatase binding]
GO:0030154 [cell differentiation]
GO:0030513 [positive regulation of BMP signaling pathway]
GO:0031053 [primary miRNA processing]
GO:0031625 [ubiquitin protein ligase binding]
GO:0032444 [activin responsive factor complex]
GO:0032924 [activin receptor signaling pathway]
GO:0032991 [protein-containing complex]
GO:0034713 [type I transforming growth factor beta receptor binding]
GO:0035556 [intracellular signal transduction]
GO:0038092 [nodal signaling pathway]
GO:0045165 [cell fate commitment]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0045944 [positive regulation of transcription by RNA polymerase II]
GO:0046332 [SMAD binding]
GO:0046872 [metal ion binding]
GO:0048156 [tau protein binding]
GO:0048340 [paraxial mesoderm morphogenesis]
GO:0051098 [regulation of binding]
GO:0060395 [SMAD protein signal transduction]
GO:0062009 [secondary palate development]
GO:0070410 [co-SMAD binding]
GO:0070411 [I-SMAD binding]
GO:0070412 [R-SMAD binding]
GO:0070723 [response to cholesterol]
GO:0071141 [SMAD protein complex]
GO:0071142 [homomeric SMAD protein complex]
GO:0071144 [heteromeric SMAD protein complex]
GO:0097718 [disordered domain specific binding]
GO:0140297 [DNA-binding transcription factor binding]
GO:1900224 [positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry]
Show all
 437 aa
49 kDa 		No 0
SMAD2-207
ENSP00000465355
ENST00000586514
K7EJX0
[Direct mapping] Mothers against decapentaplegic homolog 2
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the circulatory system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0006355 [regulation of DNA-templated transcription]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
Show all
 217 aa
24.5 kDa 		No 0
SMAD2-208
ENSP00000466254
ENST00000587269
K7EJX0
[Direct mapping] Mothers against decapentaplegic homolog 2
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the circulatory system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0006355 [regulation of DNA-templated transcription]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
Show all
 217 aa
24.5 kDa 		No 0
SMAD2-210
ENSP00000468202
ENST00000587421
K7ERC7
[Direct mapping] Mothers against decapentaplegic homolog 2
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the circulatory system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0006355 [regulation of DNA-templated transcription]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
Show all
 137 aa
15.2 kDa 		No 0
SMAD2-211
ENSP00000465971
ENST00000589877
K7EL92
[Direct mapping] Mothers against decapentaplegic homolog 2
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the circulatory system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0006355 [regulation of DNA-templated transcription]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
Show all
 109 aa
11.9 kDa 		No 0
SMAD2-212
ENSP00000467075
ENST00000591214
B7Z5N5
[Direct mapping] Mothers against decapentaplegic homolog
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Human disease related genes
   Cancers
   Cancers of the digestive system
   Congenital malformations
   Congenital malformations of the circulatory system
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription regulator complex]
GO:0005737 [cytoplasm]
GO:0006355 [regulation of DNA-templated transcription]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0016020 [membrane]
GO:0046872 [metal ion binding]
Show all
 431 aa
48.7 kDa 		No 1

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