We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Candidate cardiovascular disease genes Disease related genes Enzymes FDA approved drug targets Human disease related genes Metabolic proteins Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
8
Cytoband
p21.3
Chromosome location (bp)
19901717 - 19967259
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage 1,2,3. Although it has both phospholipase and triglyceride lipase activities it is primarily a triglyceride lipase with low but detectable phospholipase activity 4,5. Mediates margination of triglyceride-rich lipoprotein particles in capillaries 6. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans 7,8....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Heparin-binding, Hydrolase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Lipid degradation, Lipid metabolism
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium, Metal-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Congenital disorders of metabolism Congenital disorders of lipid/glycolipid metabolism Endocrine and metabolic diseases Other endocrine and metabolic diseases Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases Metabolic proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes FDA approved drug targets Small molecule drugs Human disease related genes Congenital disorders of metabolism Congenital disorders of lipid/glycolipid metabolism Endocrine and metabolic diseases Other endocrine and metabolic diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004465[lipoprotein lipase activity] GO:0004620[phospholipase activity] GO:0004806[triglyceride lipase activity] GO:0005102[signaling receptor binding] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005886[plasma membrane] GO:0006629[lipid metabolic process] GO:0006631[fatty acid metabolic process] GO:0006633[fatty acid biosynthetic process] GO:0006641[triglyceride metabolic process] GO:0006644[phospholipid metabolic process] GO:0008201[heparin binding] GO:0008970[phospholipase A1 activity] GO:0009409[response to cold] GO:0009410[response to xenobiotic stimulus] GO:0009617[response to bacterium] GO:0009749[response to glucose] GO:0009986[cell surface] GO:0010744[positive regulation of macrophage derived foam cell differentiation] GO:0010884[positive regulation of lipid storage] GO:0010886[positive regulation of cholesterol storage] GO:0010890[positive regulation of sequestering of triglyceride] GO:0016020[membrane] GO:0016042[lipid catabolic process] GO:0016298[lipase activity] GO:0016787[hydrolase activity] GO:0017129[triglyceride binding] GO:0019432[triglyceride biosynthetic process] GO:0019433[triglyceride catabolic process] GO:0031670[cellular response to nutrient] GO:0032722[positive regulation of chemokine production] GO:0032731[positive regulation of interleukin-1 beta production] GO:0032755[positive regulation of interleukin-6 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0034185[apolipoprotein binding] GO:0034361[very-low-density lipoprotein particle] GO:0034371[chylomicron remodeling] GO:0034372[very-low-density lipoprotein particle remodeling] GO:0042627[chylomicron] GO:0042632[cholesterol homeostasis] GO:0042803[protein homodimerization activity] GO:0043395[heparan sulfate proteoglycan binding] GO:0043495[protein-membrane adaptor activity] GO:0045600[positive regulation of fat cell differentiation] GO:0046872[metal ion binding] GO:0050729[positive regulation of inflammatory response] GO:0052689[carboxylic ester hydrolase activity] GO:0052739[phosphatidylserine 1-acylhydrolase activity] GO:0052740[1-acyl-2-lysophosphatidylserine acylhydrolase activity] GO:0055096[low-density lipoprotein particle mediated signaling] GO:0070328[triglyceride homeostasis] GO:0071398[cellular response to fatty acid] GO:0071813[lipoprotein particle binding] GO:1900077[negative regulation of cellular response to insulin stimulus] GO:1902494[catalytic complex] GO:2000343[positive regulation of chemokine (C-X-C motif) ligand 2 production]
The Human Protein Atlas project is funded
