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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
q11.2
Chromosome location (bp)
32486993 - 32491253
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-BMAL1 heterodimer in association with altered stability and subcellular distribution....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Biological rhythms
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5); the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0000079[regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000226[microtubule cytoskeleton organization] GO:0000307[cyclin-dependent protein kinase holoenzyme complex] GO:0001764[neuron migration] GO:0002020[protease binding] GO:0003779[actin binding] GO:0004672[protein kinase activity] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0007158[neuron cell-cell adhesion] GO:0007213[G protein-coupled acetylcholine receptor signaling pathway] GO:0007411[axon guidance] GO:0007413[axonal fasciculation] GO:0007420[brain development] GO:0009792[embryo development ending in birth or egg hatching] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0016241[regulation of macroautophagy] GO:0016301[kinase activity] GO:0016533[protein kinase 5 complex] GO:0018105[peptidyl-serine phosphorylation] GO:0018107[peptidyl-threonine phosphorylation] GO:0019901[protein kinase binding] GO:0021549[cerebellum development] GO:0021722[superior olivary nucleus maturation] GO:0021766[hippocampus development] GO:0021799[cerebral cortex radially oriented cell migration] GO:0021819[layer formation in cerebral cortex] GO:0030182[neuron differentiation] GO:0030295[protein kinase activator activity] GO:0030424[axon] GO:0030425[dendrite] GO:0030426[growth cone] GO:0031116[positive regulation of microtubule polymerization] GO:0031175[neuron projection development] GO:0031594[neuromuscular junction] GO:0032956[regulation of actin cytoskeleton organization] GO:0035235[ionotropic glutamate receptor signaling pathway] GO:0035255[ionotropic glutamate receptor binding] GO:0042501[serine phosphorylation of STAT protein] GO:0042995[cell projection] GO:0043005[neuron projection] GO:0043014[alpha-tubulin binding] GO:0043025[neuronal cell body] GO:0043197[dendritic spine] GO:0043204[perikaryon] GO:0043231[intracellular membrane-bounded organelle] GO:0043292[contractile fiber] GO:0043525[positive regulation of neuron apoptotic process] GO:0043539[protein serine/threonine kinase activator activity] GO:0045296[cadherin binding] GO:0045664[regulation of neuron differentiation] GO:0045860[positive regulation of protein kinase activity] GO:0045892[negative regulation of DNA-templated transcription] GO:0046875[ephrin receptor binding] GO:0048013[ephrin receptor signaling pathway] GO:0048471[perinuclear region of cytoplasm] GO:0048487[beta-tubulin binding] GO:0048511[rhythmic process] GO:0051015[actin filament binding] GO:0061001[regulation of dendritic spine morphogenesis] GO:0061575[cyclin-dependent protein serine/threonine kinase activator activity] GO:0070315[G1 to G0 transition involved in cell differentiation] GO:0070507[regulation of microtubule cytoskeleton organization] GO:0090314[positive regulation of protein targeting to membrane] GO:0098693[regulation of synaptic vesicle cycle] GO:0098793[presynapse]
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