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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Jun proto-oncogene, AP-1 transcription factor subunit
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes FDA approved drug targets Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
p32.1
Chromosome location (bp)
58776845 - 58784048
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Transcription factor that recognizes and binds to the AP-1 consensus motif 5'-TGA[GC]TCA-3' 1,2. Heterodimerizes with proteins of the FOS family to form an AP-1 transcription complex, thereby enhancing its DNA binding activity to the AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing its transcriptional activity (By similarity). Together with FOSB, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signaling pathway 3. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation 4. Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells 5. Binds to the USP28 promoter in colorectal cancer (CRC) cells 6....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene is the putative transforming gene of avian sarcoma virus 17. It encodes a protein which is highly similar to the viral protein, and which interacts directly with specific target DNA sequences to regulate gene expression. This gene is intronless and is mapped to 1p32-p31, a chromosomal region involved in both translocations and deletions in human malignancies. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Basic domains Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Amplifications COSMIC Somatic Mutations FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000228[nuclear chromosome] GO:0000785[chromatin] GO:0000791[euchromatin] GO:0000976[transcription cis-regulatory region binding] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001525[angiogenesis] GO:0001774[microglial cell activation] GO:0001889[liver development] GO:0001938[positive regulation of endothelial cell proliferation] GO:0003151[outflow tract morphogenesis] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003690[double-stranded DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0003723[RNA binding] GO:0005096[GTPase activator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005886[plasma membrane] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006915[apoptotic process] GO:0007179[transforming growth factor beta receptor signaling pathway] GO:0008283[cell population proliferation] GO:0008285[negative regulation of cell population proliferation] GO:0009410[response to xenobiotic stimulus] GO:0010634[positive regulation of epithelial cell migration] GO:0017053[transcription repressor complex] GO:0019899[enzyme binding] GO:0030224[monocyte differentiation] GO:0031103[axon regeneration] GO:0031625[ubiquitin protein ligase binding] GO:0031953[negative regulation of protein autophosphorylation] GO:0034614[cellular response to reactive oxygen species] GO:0035026[leading edge cell differentiation] GO:0035497[cAMP response element binding] GO:0035976[transcription factor AP-1 complex] GO:0035994[response to muscle stretch] GO:0042127[regulation of cell population proliferation] GO:0042802[identical protein binding] GO:0043065[positive regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043392[negative regulation of DNA binding] GO:0043524[negative regulation of neuron apoptotic process] GO:0043922[negative regulation by host of viral transcription] GO:0043923[positive regulation by host of viral transcription] GO:0044389[ubiquitin-like protein ligase binding] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048146[positive regulation of fibroblast proliferation] GO:0051726[regulation of cell cycle] GO:0060395[SMAD protein signal transduction] GO:0061029[eyelid development in camera-type eye] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0070412[R-SMAD binding] GO:0071276[cellular response to cadmium ion] GO:0071277[cellular response to calcium ion] GO:0072740[cellular response to anisomycin] GO:0090575[RNA polymerase II transcription regulator complex] GO:0140296[general transcription initiation factor binding] GO:0140467[integrated stress response signaling] GO:1901522[positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus] GO:1902895[positive regulation of miRNA transcription] GO:1904707[positive regulation of vascular associated smooth muscle cell proliferation] GO:1990441[negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000144[positive regulation of DNA-templated transcription initiation]
The Human Protein Atlas project is funded
