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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
19
Cytoband
p13.3
Chromosome location (bp)
4043303 - 4066899
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Transcription factor that represses the transcription of a wide range of genes involved in cell proliferation and differentiation 1,2,3,4,5,6. Directly and specifically binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3' and represses transcription both by regulating the organization of chromatin and through the direct recruitment of transcription factors to gene regulatory regions 7,8,9,10,11. Negatively regulates SMAD4 transcriptional activity in the TGF-beta signaling pathway through these two mechanisms 12. That is, recruits the chromatin regulator HDAC1 to the SMAD4-DNA complex and in parallel prevents the recruitment of the transcriptional activators CREBBP and EP300 13. Collaborates with transcription factors like RELA to modify the accessibility of gene transcription regulatory regions to secondary transcription factors (By similarity). Also directly interacts with transcription factors like SP1 to prevent their binding to DNA 14. Functions as an androgen receptor/AR transcriptional corepressor by recruiting NCOR1 and NCOR2 to the androgen response elements/ARE on target genes 15. Thereby, negatively regulates androgen receptor signaling and androgen-induced cell proliferation 16. Involved in the switch between fetal and adult globin expression during erythroid cells maturation 17. Through its interaction with the NuRD complex regulates chromatin at the fetal globin genes to repress their transcription 18. Specifically represses the transcription of the tumor suppressor ARF isoform from the CDKN2A gene (By similarity). Efficiently abrogates E2F1-dependent CDKN2A transactivation (By similarity). Regulates chondrogenesis through the transcriptional repression of specific genes via a mechanism that also requires histone deacetylation (By similarity). Regulates cell proliferation through the transcriptional regulation of genes involved in glycolysis 19. Involved in adipogenesis through the regulation of genes involved in adipocyte differentiation 20. Plays a key role in the differentiation of lymphoid progenitors into B and T lineages (By similarity). Promotes differentiation towards the B lineage by inhibiting the T-cell instructive Notch signaling pathway through the specific transcriptional repression of Notch downstream target genes (By similarity). Also regulates osteoclast differentiation (By similarity). May also play a role, independently of its transcriptional activity, in double-strand break repair via classical non-homologous end joining/cNHEJ (By similarity). Recruited to double-strand break sites on damage DNA, interacts with the DNA-dependent protein kinase complex and directly regulates its stability and activity in DNA repair (By similarity). May also modulate the splicing activity of KHDRBS1 toward BCL2L1 in a mechanism which is histone deacetylase-dependent and thereby negatively regulates the pro-apoptotic effect of KHDRBS1 21....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Developmental protein, DNA-binding, Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables several functions, including SMAD binding activity; androgen receptor binding activity; and transcription corepressor binding activity. Involved in several processes, including erythrocyte maturation; negative regulation of signal transduction; and regulation of nucleobase-containing compound metabolic process. Located in cytoplasm and nucleus. Colocalizes with DNA-dependent protein kinase complex and NuRD complex. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
O95365 [Direct mapping] Zinc finger and BTB domain-containing protein 7A
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000381[regulation of alternative mRNA splicing, via spliceosome] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001222[transcription corepressor binding] GO:0001227[DNA-binding transcription repressor activity, RNA polymerase II-specific] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0006110[regulation of glycolytic process] GO:0006325[chromatin organization] GO:0006338[chromatin remodeling] GO:0006351[DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0016581[NuRD complex] GO:0030154[cell differentiation] GO:0030183[B cell differentiation] GO:0030512[negative regulation of transforming growth factor beta receptor signaling pathway] GO:0034504[protein localization to nucleus] GO:0035035[histone acetyltransferase binding] GO:0035861[site of double-strand break] GO:0042981[regulation of apoptotic process] GO:0043249[erythrocyte maturation] GO:0043565[sequence-specific DNA binding] GO:0045444[fat cell differentiation] GO:0045746[negative regulation of Notch signaling pathway] GO:0045892[negative regulation of DNA-templated transcription] GO:0046332[SMAD binding] GO:0046872[metal ion binding] GO:0050681[nuclear androgen receptor binding] GO:0051090[regulation of DNA-binding transcription factor activity] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060766[negative regulation of androgen receptor signaling pathway] GO:0070418[DNA-dependent protein kinase complex] GO:0097680[double-strand break repair via classical nonhomologous end joining] GO:0140297[DNA-binding transcription factor binding] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000677[regulation of transcription regulatory region DNA binding]
O95365 [Direct mapping] Zinc finger and BTB domain-containing protein 7A
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000381[regulation of alternative mRNA splicing, via spliceosome] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001222[transcription corepressor binding] GO:0003677[DNA binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0006110[regulation of glycolytic process] GO:0006325[chromatin organization] GO:0006338[chromatin remodeling] GO:0006357[regulation of transcription by RNA polymerase II] GO:0016581[NuRD complex] GO:0030154[cell differentiation] GO:0030183[B cell differentiation] GO:0030512[negative regulation of transforming growth factor beta receptor signaling pathway] GO:0034504[protein localization to nucleus] GO:0035035[histone acetyltransferase binding] GO:0035861[site of double-strand break] GO:0042981[regulation of apoptotic process] GO:0043249[erythrocyte maturation] GO:0045444[fat cell differentiation] GO:0045746[negative regulation of Notch signaling pathway] GO:0045892[negative regulation of DNA-templated transcription] GO:0046332[SMAD binding] GO:0046872[metal ion binding] GO:0050681[nuclear androgen receptor binding] GO:0051090[regulation of DNA-binding transcription factor activity] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060766[negative regulation of androgen receptor signaling pathway] GO:0070418[DNA-dependent protein kinase complex] GO:0097680[double-strand break repair via classical nonhomologous end joining] GO:0140297[DNA-binding transcription factor binding] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000677[regulation of transcription regulatory region DNA binding]
The Human Protein Atlas project is funded
