Single cell type - GIMAP7 - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GIMAP7
Gene descriptionⁱ Full gene name according to HGNC.	GTPase, IMAP family member 7
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	NK-cells - Adaptive immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Group enriched (NK-cells, Endothelial cells, T-cells, Adipocytes, Lymphatic endothelial cells, Kupffer cells)
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	0.77
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Group enriched (Endothelial cell, Leukocyte)
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Low immune cell specificity
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

Single cell type

Cell type enrichment

Single nuclei - Brain

Immune cells

Expression clustering

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Group enriched (NK-cells, Endothelial cells, T-cells, Adipocytes, Lymphatic endothelial cells, Kupffer cells)

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Group enriched (Endothelial cell, Leukocyte)

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Low immune cell specificity
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

GIMAP7 is part of cluster 19 NK-cells - Adaptive immune response with confidenceⁱ 0.95
266 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
GIMAP1	GTPase, IMAP family member 1	0.9087	19
GIMAP4	GTPase, IMAP family member 4	0.8912	19
GIMAP6	GTPase, IMAP family member 6	0.8381	19
OR4D1	Olfactory receptor family 4 subfamily D member 1	0.7975	19
ANXA2R	Annexin A2 receptor	0.7894	19
BTN3A2	Butyrophilin subfamily 3 member A2	0.7746	19
OR2A25	Olfactory receptor family 2 subfamily A member 25	0.7372	19
GIMAP2	GTPase, IMAP family member 2	0.7295	19
CD8B	CD8b molecule	0.7190	19
BTN3A3	Butyrophilin subfamily 3 member A3	0.7167	19
TRAF3IP3	TRAF3 interacting protein 3	0.7008	19
SLFN5	Schlafen family member 5	0.6964	19
TRAC	T cell receptor alpha constant	0.6879	19
TXK	TXK tyrosine kinase	0.6810	19
MFNG	MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase	0.6770	19

IMMUNE CELLS

GIMAP7 is part of cluster 11 T-cells - Unknown function with confidenceⁱ 1
119 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
BLMH	Bleomycin hydrolase	1.0000	11
RTN4R	Reticulon 4 receptor	1.0000	11
METTL5	Methyltransferase 5, N6-adenosine	0.9762	11
NSG1	Neuronal vesicle trafficking associated 1	0.9762	11
SOAT2	Sterol O-acyltransferase 2	0.9762	27
ACSL6	Acyl-CoA synthetase long chain family member 6	0.9762	11
HTR6	5-hydroxytryptamine receptor 6	0.9762	11
CD8A	CD8a molecule	0.9762	11
FAM171A1	Family with sequence similarity 171 member A1	0.9762	11
SUSD4	Sushi domain containing 4	0.9762	11
SKAP1	Src kinase associated phosphoprotein 1	0.9762	11
CCDC65	Coiled-coil domain containing 65	0.9762	11
KCNH3	Potassium voltage-gated channel subfamily H member 3	0.9762	11
BCL11B	BAF chromatin remodeling complex subunit BCL11B	0.9762	11
INPP4B	Inositol polyphosphate-4-phosphatase type II B	0.9762	11