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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes Plasma proteins Potential drug targets Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
19
Cytoband
p13.13
Chromosome location (bp)
12938578 - 12944489
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER 1. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export 2. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity). Present in the cortical granules of non-activated oocytes, is exocytosed during the cortical reaction in response to oocyte activation and might participate in the block to polyspermy (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Chaperone
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium, Lectin, Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
Calreticulin is a highly conserved chaperone protein which resides primarily in the endoplasmic reticulum, and is involved in a variety of cellular processes, among them, cell adhesion. Additionally, it functions in protein folding quality control and calcium homeostasis. Calreticulin is also found in the nucleus, suggesting that it may have a role in transcription regulation. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin. Recurrent mutations in calreticulin have been linked to various neoplasms, including the myeloproliferative type.[provided by RefSeq, May 2020]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Transporters Accessory Factors Involved in Transport MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations COSMIC Frameshift Mutations Disease related genes Potential drug targets Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0001669[acrosomal vesicle] GO:0001849[complement component C1q complex binding] GO:0002502[peptide antigen assembly with MHC class I protein complex] GO:0003677[DNA binding] GO:0003723[RNA binding] GO:0003729[mRNA binding] GO:0005178[integrin binding] GO:0005506[iron ion binding] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005635[nuclear envelope] GO:0005737[cytoplasm] GO:0005764[lysosome] GO:0005783[endoplasmic reticulum] GO:0005788[endoplasmic reticulum lumen] GO:0005789[endoplasmic reticulum membrane] GO:0005790[smooth endoplasmic reticulum] GO:0005794[Golgi apparatus] GO:0005829[cytosol] GO:0005844[polysome] GO:0005886[plasma membrane] GO:0005925[focal adhesion] GO:0006355[regulation of DNA-templated transcription] GO:0006457[protein folding] GO:0006611[protein export from nucleus] GO:0006874[cellular calcium ion homeostasis] GO:0007283[spermatogenesis] GO:0008270[zinc ion binding] GO:0008284[positive regulation of cell population proliferation] GO:0009410[response to xenobiotic stimulus] GO:0009897[external side of plasma membrane] GO:0009986[cell surface] GO:0010033[response to organic substance] GO:0010595[positive regulation of endothelial cell migration] GO:0010628[positive regulation of gene expression] GO:0016020[membrane] GO:0016529[sarcoplasmic reticulum] GO:0017148[negative regulation of translation] GO:0022417[protein maturation by protein folding] GO:0030246[carbohydrate binding] GO:0030433[ubiquitin-dependent ERAD pathway] GO:0030670[phagocytic vesicle membrane] GO:0030866[cortical actin cytoskeleton organization] GO:0031410[cytoplasmic vesicle] GO:0031625[ubiquitin protein ligase binding] GO:0032355[response to estradiol] GO:0032991[protein-containing complex] GO:0033018[sarcoplasmic reticulum lumen] GO:0033116[endoplasmic reticulum-Golgi intermediate compartment membrane] GO:0033144[negative regulation of intracellular steroid hormone receptor signaling pathway] GO:0033574[response to testosterone] GO:0034504[protein localization to nucleus] GO:0034975[protein folding in endoplasmic reticulum] GO:0040020[regulation of meiotic nuclear division] GO:0042277[peptide binding] GO:0042562[hormone binding] GO:0042824[MHC class I peptide loading complex] GO:0042921[glucocorticoid receptor signaling pathway] GO:0042981[regulation of apoptotic process] GO:0043231[intracellular membrane-bounded organelle] GO:0044183[protein folding chaperone] GO:0044194[cytolytic granule] GO:0044322[endoplasmic reticulum quality control compartment] GO:0045665[negative regulation of neuron differentiation] GO:0045787[positive regulation of cell cycle] GO:0045892[negative regulation of DNA-templated transcription] GO:0046872[metal ion binding] GO:0048387[negative regulation of retinoic acid receptor signaling pathway] GO:0048471[perinuclear region of cytoplasm] GO:0050681[nuclear androgen receptor binding] GO:0050766[positive regulation of phagocytosis] GO:0050821[protein stabilization] GO:0051082[unfolded protein binding] GO:0051087[chaperone binding] GO:0051208[sequestering of calcium ion] GO:0055007[cardiac muscle cell differentiation] GO:0060473[cortical granule] GO:0061912[selective autophagy] GO:0062023[collagen-containing extracellular matrix] GO:0070062[extracellular exosome] GO:0071257[cellular response to electrical stimulus] GO:0071285[cellular response to lithium ion] GO:0071310[cellular response to organic substance] GO:0071682[endocytic vesicle lumen] GO:0090398[cellular senescence] GO:0098553[lumenal side of endoplasmic reticulum membrane] GO:0098586[cellular response to virus] GO:1900026[positive regulation of substrate adhesion-dependent cell spreading] GO:1901164[negative regulation of trophoblast cell migration] GO:1901224[positive regulation of NIK/NF-kappaB signaling] GO:1903416[response to glycoside] GO:2000510[positive regulation of dendritic cell chemotaxis]
The Human Protein Atlas project is funded
