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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes Transcription factors
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
q21.3
Chromosome location (bp)
128479427 - 128493201
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'- AGATAG-3'....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, DNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Mapped to neXtProt neXtProt - Evidence at protein level
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GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001221[transcription coregulator binding] GO:0001223[transcription coactivator binding] GO:0001228[DNA-binding transcription activator activity, RNA polymerase II-specific] GO:0001525[angiogenesis] GO:0001655[urogenital system development] GO:0001709[cell fate determination] GO:0001764[neuron migration] GO:0001892[embryonic placenta development] GO:0002067[glandular epithelial cell differentiation] GO:0002071[glandular epithelial cell maturation] GO:0002244[hematopoietic progenitor cell differentiation] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005667[transcription regulator complex] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006366[transcription by RNA polymerase II] GO:0006909[phagocytosis] GO:0007204[positive regulation of cytosolic calcium ion concentration] GO:0007405[neuroblast proliferation] GO:0007406[negative regulation of neuroblast proliferation] GO:0008270[zinc ion binding] GO:0009653[anatomical structure morphogenesis] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0010725[regulation of primitive erythrocyte differentiation] GO:0021514[ventral spinal cord interneuron differentiation] GO:0021533[cell differentiation in hindbrain] GO:0021902[commitment of neuronal cell to specific neuron type in forebrain] GO:0021954[central nervous system neuron development] GO:0021983[pituitary gland development] GO:0030097[hemopoiesis] GO:0030099[myeloid cell differentiation] GO:0030154[cell differentiation] GO:0030182[neuron differentiation] GO:0033993[response to lipid] GO:0035019[somatic stem cell population maintenance] GO:0035065[regulation of histone acetylation] GO:0035854[eosinophil fate commitment] GO:0042472[inner ear morphogenesis] GO:0043306[positive regulation of mast cell degranulation] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0043565[sequence-specific DNA binding] GO:0045165[cell fate commitment] GO:0045599[negative regulation of fat cell differentiation] GO:0045638[negative regulation of myeloid cell differentiation] GO:0045648[positive regulation of erythrocyte differentiation] GO:0045650[negative regulation of macrophage differentiation] GO:0045654[positive regulation of megakaryocyte differentiation] GO:0045666[positive regulation of neuron differentiation] GO:0045746[negative regulation of Notch signaling pathway] GO:0045766[positive regulation of angiogenesis] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0048663[neuron fate commitment] GO:0048731[system development] GO:0048873[homeostasis of number of cells within a tissue] GO:0050766[positive regulation of phagocytosis] GO:0050873[brown fat cell differentiation] GO:0060100[positive regulation of phagocytosis, engulfment] GO:0060129[thyroid-stimulating hormone-secreting cell differentiation] GO:0060216[definitive hemopoiesis] GO:0060872[semicircular canal development] GO:0061042[vascular wound healing] GO:0061101[neuroendocrine cell differentiation] GO:0061351[neural precursor cell proliferation] GO:0061484[hematopoietic stem cell homeostasis] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070345[negative regulation of fat cell proliferation] GO:0070742[C2H2 zinc finger domain binding] GO:0090050[positive regulation of cell migration involved in sprouting angiogenesis] GO:0090102[cochlea development] GO:0097154[GABAergic neuron differentiation] GO:1901533[negative regulation of hematopoietic progenitor cell differentiation] GO:1902895[positive regulation of miRNA transcription] GO:1903444[negative regulation of brown fat cell differentiation] GO:1903589[positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000178[negative regulation of neural precursor cell proliferation] GO:2000352[negative regulation of endothelial cell apoptotic process] GO:2000977[regulation of forebrain neuron differentiation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001221[transcription coregulator binding] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006909[phagocytosis] GO:0008270[zinc ion binding] GO:0009653[anatomical structure morphogenesis] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0030097[hemopoiesis] GO:0030154[cell differentiation] GO:0035854[eosinophil fate commitment] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0043565[sequence-specific DNA binding] GO:0045165[cell fate commitment] GO:0045599[negative regulation of fat cell differentiation] GO:0045746[negative regulation of Notch signaling pathway] GO:0045766[positive regulation of angiogenesis] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0048731[system development] GO:0050766[positive regulation of phagocytosis] GO:0061042[vascular wound healing] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070345[negative regulation of fat cell proliferation] GO:0070742[C2H2 zinc finger domain binding] GO:0090050[positive regulation of cell migration involved in sprouting angiogenesis] GO:1902895[positive regulation of miRNA transcription] GO:1903589[positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000178[negative regulation of neural precursor cell proliferation] GO:2000352[negative regulation of endothelial cell apoptotic process]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Transcription factors Zinc-coordinating DNA-binding domains Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Disease related genes Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0001221[transcription coregulator binding] GO:0003677[DNA binding] GO:0003682[chromatin binding] GO:0003700[DNA-binding transcription factor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0006909[phagocytosis] GO:0008270[zinc ion binding] GO:0009653[anatomical structure morphogenesis] GO:0010628[positive regulation of gene expression] GO:0010629[negative regulation of gene expression] GO:0030097[hemopoiesis] GO:0030154[cell differentiation] GO:0035854[eosinophil fate commitment] GO:0043536[positive regulation of blood vessel endothelial cell migration] GO:0043565[sequence-specific DNA binding] GO:0045165[cell fate commitment] GO:0045599[negative regulation of fat cell differentiation] GO:0045746[negative regulation of Notch signaling pathway] GO:0045766[positive regulation of angiogenesis] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046872[metal ion binding] GO:0048731[system development] GO:0050766[positive regulation of phagocytosis] GO:0061042[vascular wound healing] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070345[negative regulation of fat cell proliferation] GO:0070742[C2H2 zinc finger domain binding] GO:0090050[positive regulation of cell migration involved in sprouting angiogenesis] GO:1902895[positive regulation of miRNA transcription] GO:1903589[positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis] GO:1990837[sequence-specific double-stranded DNA binding] GO:2000178[negative regulation of neural precursor cell proliferation] GO:2000352[negative regulation of endothelial cell apoptotic process]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases
Show all
GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003700[DNA-binding transcription factor activity] GO:0005634[nucleus] GO:0006357[regulation of transcription by RNA polymerase II] GO:0030097[hemopoiesis]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases
Show all
GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003700[DNA-binding transcription factor activity] GO:0005634[nucleus] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008270[zinc ion binding] GO:0030097[hemopoiesis] GO:0043565[sequence-specific DNA binding]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases
Show all
GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003700[DNA-binding transcription factor activity] GO:0005634[nucleus] GO:0006357[regulation of transcription by RNA polymerase II] GO:0030097[hemopoiesis]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases
Show all
GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003700[DNA-binding transcription factor activity] GO:0005634[nucleus] GO:0006357[regulation of transcription by RNA polymerase II] GO:0030097[hemopoiesis]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases
Show all
GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003700[DNA-binding transcription factor activity] GO:0005634[nucleus] GO:0006357[regulation of transcription by RNA polymerase II] GO:0030097[hemopoiesis]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases
Show all
GO:0000981[DNA-binding transcription factor activity, RNA polymerase II-specific] GO:0003700[DNA-binding transcription factor activity] GO:0005634[nucleus] GO:0006357[regulation of transcription by RNA polymerase II] GO:0030097[hemopoiesis]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Missense Mutations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Cardiovascular diseases Hematologic diseases
Show all
GO:0003700[DNA-binding transcription factor activity] GO:0006355[regulation of DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008270[zinc ion binding] GO:0043565[sequence-specific DNA binding]
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