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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Metabolic proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
17
Cytoband
p13.1
Chromosome location (bp)
8039034 - 8049134
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
[Isoform A]: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids (PUFAs) generating a spectrum of bioactive lipid mediators (Probable) 1,2,3,4,5,6,7,8,9. It inserts peroxyl groups at C15 of arachidonate ((5Z,8Z,11Z,14Z)-eicosatetraenoate) producing (15S)-hydroperoxyeicosatetraenoate/(15S)-HPETE (Probable) 10,11,12,13,14,15,16. Also peroxidizes linoleate ((9Z,12Z)-octadecadienoate) to 13-hydroperoxyoctadecadienoate/13-HPODE (Probable) 17,18. Oxygenates arachidonyl derivatives such as 2-arachidonoylglycerol (2-AG) leading to the production and extracellular release of 15-hydroxyeicosatetraenoyl glycerol (15-HETE-G) that acts as a peroxisome proliferator-activated receptor alpha agonist 19,20,21. Has the ability to efficiently class-switch ALOX5 pro-inflammatory mediators into anti-inflammatory intermediates 22. Participates in the sequential oxidations of DHA ((4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate) to generate specialized pro-resolving mediators (SPMs) resolvin D5 ((7S,17S)-diHPDHA), which can actively down-regulate the immune response and have anti-aggregation properties with platelets 23. In addition to free PUFAs hydrolyzed from phospholipids, it directly oxidizes PUFAs esterified to membrane-bound phospholipids 24. Has no detectable 8S-lipoxygenase activity on arachidonate but reacts with (8S)-HPETE to produce (8S,15S)-diHPETE (Probable). May regulate progression through the cell cycle and cell proliferation 25,26. May also regulate cytokine secretion by macrophages and therefore play a role in the immune response 27. May also regulate macrophage differentiation into proatherogenic foam cells 28....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Dioxygenase, Oxidoreductase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Lipid metabolism
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium, Iron, Lipid-binding, Metal-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001676[long-chain fatty acid metabolic process] GO:0005506[iron ion binding] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0005912[adherens junction] GO:0005925[focal adhesion] GO:0006629[lipid metabolic process] GO:0006644[phospholipid metabolic process] GO:0006690[icosanoid metabolic process] GO:0006915[apoptotic process] GO:0008285[negative regulation of cell population proliferation] GO:0008289[lipid binding] GO:0010744[positive regulation of macrophage derived foam cell differentiation] GO:0016020[membrane] GO:0016165[linoleate 13S-lipoxygenase activity] GO:0016491[oxidoreductase activity] GO:0016702[oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0019369[arachidonic acid metabolic process] GO:0019372[lipoxygenase pathway] GO:0019898[extrinsic component of membrane] GO:0030336[negative regulation of cell migration] GO:0030850[prostate gland development] GO:0030856[regulation of epithelial cell differentiation] GO:0032722[positive regulation of chemokine production] GO:0034440[lipid oxidation] GO:0043651[linoleic acid metabolic process] GO:0045786[negative regulation of cell cycle] GO:0045926[negative regulation of growth] GO:0046872[metal ion binding] GO:0050473[arachidonate 15-lipoxygenase activity] GO:0051122[hepoxilin biosynthetic process] GO:0051213[dioxygenase activity] GO:0070062[extracellular exosome] GO:0070161[anchoring junction] GO:0071926[endocannabinoid signaling pathway] GO:1901696[cannabinoid biosynthetic process] GO:2001303[lipoxin A4 biosynthetic process]
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001676[long-chain fatty acid metabolic process] GO:0005506[iron ion binding] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0005912[adherens junction] GO:0005925[focal adhesion] GO:0006629[lipid metabolic process] GO:0006644[phospholipid metabolic process] GO:0006690[icosanoid metabolic process] GO:0006915[apoptotic process] GO:0008285[negative regulation of cell population proliferation] GO:0008289[lipid binding] GO:0010744[positive regulation of macrophage derived foam cell differentiation] GO:0016020[membrane] GO:0016165[linoleate 13S-lipoxygenase activity] GO:0016491[oxidoreductase activity] GO:0016702[oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0019369[arachidonic acid metabolic process] GO:0019372[lipoxygenase pathway] GO:0019898[extrinsic component of membrane] GO:0030336[negative regulation of cell migration] GO:0030850[prostate gland development] GO:0030856[regulation of epithelial cell differentiation] GO:0032722[positive regulation of chemokine production] GO:0034440[lipid oxidation] GO:0035360[positive regulation of peroxisome proliferator activated receptor signaling pathway] GO:0036403[arachidonate 8(S)-lipoxygenase activity] GO:0043651[linoleic acid metabolic process] GO:0045618[positive regulation of keratinocyte differentiation] GO:0045786[negative regulation of cell cycle] GO:0045926[negative regulation of growth] GO:0046872[metal ion binding] GO:0050473[arachidonate 15-lipoxygenase activity] GO:0051122[hepoxilin biosynthetic process] GO:0051213[dioxygenase activity] GO:0070062[extracellular exosome] GO:0070161[anchoring junction] GO:0071926[endocannabinoid signaling pathway] GO:1901696[cannabinoid biosynthetic process] GO:1990136[linoleate 9S-lipoxygenase activity] GO:2001303[lipoxin A4 biosynthetic process]
Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001676[long-chain fatty acid metabolic process] GO:0005506[iron ion binding] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0005912[adherens junction] GO:0005925[focal adhesion] GO:0006629[lipid metabolic process] GO:0006644[phospholipid metabolic process] GO:0006690[icosanoid metabolic process] GO:0006915[apoptotic process] GO:0008285[negative regulation of cell population proliferation] GO:0008289[lipid binding] GO:0010744[positive regulation of macrophage derived foam cell differentiation] GO:0016020[membrane] GO:0016165[linoleate 13S-lipoxygenase activity] GO:0016491[oxidoreductase activity] GO:0016702[oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0019369[arachidonic acid metabolic process] GO:0019372[lipoxygenase pathway] GO:0019898[extrinsic component of membrane] GO:0030336[negative regulation of cell migration] GO:0030850[prostate gland development] GO:0030856[regulation of epithelial cell differentiation] GO:0032722[positive regulation of chemokine production] GO:0034440[lipid oxidation] GO:0043651[linoleic acid metabolic process] GO:0045786[negative regulation of cell cycle] GO:0045926[negative regulation of growth] GO:0046872[metal ion binding] GO:0050473[arachidonate 15-lipoxygenase activity] GO:0051122[hepoxilin biosynthetic process] GO:0051213[dioxygenase activity] GO:0070062[extracellular exosome] GO:0070161[anchoring junction] GO:0071926[endocannabinoid signaling pathway] GO:1901696[cannabinoid biosynthetic process] GO:2001303[lipoxin A4 biosynthetic process]
The Human Protein Atlas project is funded
