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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Candidate cardiovascular disease genes Disease related genes Human disease related genes Plasma proteins Potential drug targets Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
3
Cytoband
q27.3
Chromosome location (bp)
186842704 - 186858463
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hormone
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene is expressed in adipose tissue exclusively. It encodes a protein with similarity to collagens X and VIII and complement factor C1q. The encoded protein circulates in the plasma and is involved with metabolic and hormonal processes. Mutations in this gene are associated with adiponectin deficiency. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Apr 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
A8K660 [Target identity:100%; Query identity:100%] Adiponectin; Adiponectin, C1Q and collagen domain containing; cDNA FLJ78108, highly similar to Homo sapiens adiponectin, C1Q and collagen domain containing (ADIPOQ), mRNA
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Transporters Accessory Factors Involved in Transport SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes Potential drug targets Human disease related genes Congenital disorders of metabolism Other congenital disorders of metabolism Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001666[response to hypoxia] GO:0001934[positive regulation of protein phosphorylation] GO:0005102[signaling receptor binding] GO:0005125[cytokine activity] GO:0005179[hormone activity] GO:0005201[extracellular matrix structural constituent] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005581[collagen trimer] GO:0005615[extracellular space] GO:0005783[endoplasmic reticulum] GO:0006006[glucose metabolic process] GO:0006091[generation of precursor metabolites and energy] GO:0006635[fatty acid beta-oxidation] GO:0007165[signal transduction] GO:0007584[response to nutrient] GO:0007623[circadian rhythm] GO:0009410[response to xenobiotic stimulus] GO:0009617[response to bacterium] GO:0009744[response to sucrose] GO:0009749[response to glucose] GO:0009967[positive regulation of signal transduction] GO:0009986[cell surface] GO:0010467[gene expression] GO:0010642[negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0010739[positive regulation of protein kinase A signaling] GO:0010745[negative regulation of macrophage derived foam cell differentiation] GO:0010804[negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0010875[positive regulation of cholesterol efflux] GO:0010906[regulation of glucose metabolic process] GO:0014823[response to activity] GO:0019395[fatty acid oxidation] GO:0030336[negative regulation of cell migration] GO:0030853[negative regulation of granulocyte differentiation] GO:0031667[response to nutrient levels] GO:0031953[negative regulation of protein autophosphorylation] GO:0032720[negative regulation of tumor necrosis factor production] GO:0032757[positive regulation of interleukin-8 production] GO:0032869[cellular response to insulin stimulus] GO:0032991[protein-containing complex] GO:0033034[positive regulation of myeloid cell apoptotic process] GO:0033691[sialic acid binding] GO:0034115[negative regulation of heterotypic cell-cell adhesion] GO:0034383[low-density lipoprotein particle clearance] GO:0034612[response to tumor necrosis factor] GO:0042593[glucose homeostasis] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043407[negative regulation of MAP kinase activity] GO:0045471[response to ethanol] GO:0045599[negative regulation of fat cell differentiation] GO:0045650[negative regulation of macrophage differentiation] GO:0045721[negative regulation of gluconeogenesis] GO:0045776[negative regulation of blood pressure] GO:0045860[positive regulation of protein kinase activity] GO:0045892[negative regulation of DNA-templated transcription] GO:0045923[positive regulation of fatty acid metabolic process] GO:0046326[positive regulation of glucose import] GO:0046888[negative regulation of hormone secretion] GO:0050728[negative regulation of inflammatory response] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0050765[negative regulation of phagocytosis] GO:0050805[negative regulation of synaptic transmission] GO:0050873[brown fat cell differentiation] GO:0051384[response to glucocorticoid] GO:0062023[collagen-containing extracellular matrix] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0070543[response to linoleic acid] GO:0070994[detection of oxidative stress] GO:0071320[cellular response to cAMP] GO:0071466[cellular response to xenobiotic stimulus] GO:0071639[positive regulation of monocyte chemotactic protein-1 production] GO:0071872[cellular response to epinephrine stimulus] GO:0072659[protein localization to plasma membrane] GO:0090317[negative regulation of intracellular protein transport] GO:0110113[positive regulation of lipid transporter activity] GO:0120162[positive regulation of cold-induced thermogenesis] GO:0120163[negative regulation of cold-induced thermogenesis] GO:1900121[negative regulation of receptor binding] GO:1904706[negative regulation of vascular associated smooth muscle cell proliferation] GO:1904753[negative regulation of vascular associated smooth muscle cell migration] GO:1905598[negative regulation of low-density lipoprotein receptor activity] GO:2000279[negative regulation of DNA biosynthetic process] GO:2000467[positive regulation of glycogen (starch) synthase activity] GO:2000478[positive regulation of metanephric podocyte development] GO:2000481[positive regulation of cAMP-dependent protein kinase activity] GO:2000534[positive regulation of renal albumin absorption] GO:2000584[negative regulation of platelet-derived growth factor receptor-alpha signaling pathway] GO:2000590[negative regulation of metanephric mesenchymal cell migration]
A8K660 [Target identity:100%; Query identity:100%] Adiponectin; Adiponectin, C1Q and collagen domain containing; cDNA FLJ78108, highly similar to Homo sapiens adiponectin, C1Q and collagen domain containing (ADIPOQ), mRNA
Show all
Transporters Accessory Factors Involved in Transport SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Plasma proteins Candidate cardiovascular disease genes Disease related genes Potential drug targets Human disease related genes Congenital disorders of metabolism Other congenital disorders of metabolism Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001934[positive regulation of protein phosphorylation] GO:0005102[signaling receptor binding] GO:0005125[cytokine activity] GO:0005179[hormone activity] GO:0005201[extracellular matrix structural constituent] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005581[collagen trimer] GO:0005615[extracellular space] GO:0005783[endoplasmic reticulum] GO:0006006[glucose metabolic process] GO:0006091[generation of precursor metabolites and energy] GO:0006635[fatty acid beta-oxidation] GO:0007165[signal transduction] GO:0009749[response to glucose] GO:0009967[positive regulation of signal transduction] GO:0009986[cell surface] GO:0010642[negative regulation of platelet-derived growth factor receptor signaling pathway] GO:0010739[positive regulation of protein kinase A signaling] GO:0010745[negative regulation of macrophage derived foam cell differentiation] GO:0010804[negative regulation of tumor necrosis factor-mediated signaling pathway] GO:0010875[positive regulation of cholesterol efflux] GO:0010906[regulation of glucose metabolic process] GO:0019395[fatty acid oxidation] GO:0030336[negative regulation of cell migration] GO:0030853[negative regulation of granulocyte differentiation] GO:0031953[negative regulation of protein autophosphorylation] GO:0032720[negative regulation of tumor necrosis factor production] GO:0032757[positive regulation of interleukin-8 production] GO:0032869[cellular response to insulin stimulus] GO:0033034[positive regulation of myeloid cell apoptotic process] GO:0033691[sialic acid binding] GO:0034115[negative regulation of heterotypic cell-cell adhesion] GO:0034383[low-density lipoprotein particle clearance] GO:0034612[response to tumor necrosis factor] GO:0042593[glucose homeostasis] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043407[negative regulation of MAP kinase activity] GO:0045599[negative regulation of fat cell differentiation] GO:0045650[negative regulation of macrophage differentiation] GO:0045721[negative regulation of gluconeogenesis] GO:0045776[negative regulation of blood pressure] GO:0045892[negative regulation of DNA-templated transcription] GO:0045923[positive regulation of fatty acid metabolic process] GO:0046326[positive regulation of glucose import] GO:0050728[negative regulation of inflammatory response] GO:0050765[negative regulation of phagocytosis] GO:0050805[negative regulation of synaptic transmission] GO:0050873[brown fat cell differentiation] GO:0062023[collagen-containing extracellular matrix] GO:0070373[negative regulation of ERK1 and ERK2 cascade] GO:0070994[detection of oxidative stress] GO:0071466[cellular response to xenobiotic stimulus] GO:0071639[positive regulation of monocyte chemotactic protein-1 production] GO:0072659[protein localization to plasma membrane] GO:0090317[negative regulation of intracellular protein transport] GO:0110113[positive regulation of lipid transporter activity] GO:0120162[positive regulation of cold-induced thermogenesis] GO:0120163[negative regulation of cold-induced thermogenesis] GO:1900121[negative regulation of receptor binding] GO:1904706[negative regulation of vascular associated smooth muscle cell proliferation] GO:1904753[negative regulation of vascular associated smooth muscle cell migration] GO:1905598[negative regulation of low-density lipoprotein receptor activity] GO:2000279[negative regulation of DNA biosynthetic process] GO:2000467[positive regulation of glycogen (starch) synthase activity] GO:2000478[positive regulation of metanephric podocyte development] GO:2000481[positive regulation of cAMP-dependent protein kinase activity] GO:2000534[positive regulation of renal albumin absorption] GO:2000584[negative regulation of platelet-derived growth factor receptor-alpha signaling pathway] GO:2000590[negative regulation of metanephric mesenchymal cell migration]
The Human Protein Atlas project is funded
