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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
5
Cytoband
q35.1
Chromosome location (bp)
171387116 - 171411810
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidized rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation. Antagonizes the inhibitory effect of ATF5 on cell proliferation and relieves ATF5-induced G2/M blockade 1. In complex with MYC enhances the transcription of MYC target genes 2. May act as chaperonin or cotransporter in the nucleolar localization of transcription termination factor TTF1 (By similarity)....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Chaperone, RNA-binding
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Host-virus interaction
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is involved in several cellular processes, including centrosome duplication, protein chaperoning, and cell proliferation. The encoded phosphoprotein shuttles between the nucleolus, nucleus, and cytoplasm, chaperoning ribosomal proteins and core histones from the nucleus to the cytoplasm. This protein is also known to sequester the tumor suppressor ARF in the nucleolus, protecting it from degradation until it is needed. Mutations in this gene are associated with acute myeloid leukemia. Dozens of pseudogenes of this gene have been identified. [provided by RefSeq, Aug 2017]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000055[ribosomal large subunit export from nucleus] GO:0000056[ribosomal small subunit export from nucleus] GO:0001046[core promoter sequence-specific DNA binding] GO:0001652[granular component] GO:0003676[nucleic acid binding] GO:0003682[chromatin binding] GO:0003713[transcription coactivator activity] GO:0003723[RNA binding] GO:0004860[protein kinase inhibitor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005925[focal adhesion] GO:0006281[DNA repair] GO:0006334[nucleosome assembly] GO:0006338[chromatin remodeling] GO:0006407[rRNA export from nucleus] GO:0006886[intracellular protein transport] GO:0006913[nucleocytoplasmic transport] GO:0007098[centrosome cycle] GO:0007165[signal transduction] GO:0008104[protein localization] GO:0008284[positive regulation of cell population proliferation] GO:0008285[negative regulation of cell population proliferation] GO:0010824[regulation of centrosome duplication] GO:0010826[negative regulation of centrosome duplication] GO:0016020[membrane] GO:0019843[rRNA binding] GO:0019901[protein kinase binding] GO:0030957[Tat protein binding] GO:0031616[spindle pole centrosome] GO:0032071[regulation of endodeoxyribonuclease activity] GO:0032991[protein-containing complex] GO:0032993[protein-DNA complex] GO:0034644[cellular response to UV] GO:0042255[ribosome assembly] GO:0042273[ribosomal large subunit biogenesis] GO:0042274[ribosomal small subunit biogenesis] GO:0042393[histone binding] GO:0042803[protein homodimerization activity] GO:0043023[ribosomal large subunit binding] GO:0043024[ribosomal small subunit binding] GO:0043066[negative regulation of apoptotic process] GO:0044387[negative regulation of protein kinase activity by regulation of protein phosphorylation] GO:0045727[positive regulation of translation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046599[regulation of centriole replication] GO:0051059[NF-kappaB binding] GO:0051082[unfolded protein binding] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060699[regulation of endoribonuclease activity] GO:0060735[regulation of eIF2 alpha phosphorylation by dsRNA] GO:0090398[cellular senescence] GO:0140297[DNA-binding transcription factor binding] GO:0140693[molecular condensate scaffold activity] GO:1902629[regulation of mRNA stability involved in cellular response to UV] GO:1902751[positive regulation of cell cycle G2/M phase transition] GO:1990904[ribonucleoprotein complex]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000055[ribosomal large subunit export from nucleus] GO:0000056[ribosomal small subunit export from nucleus] GO:0001046[core promoter sequence-specific DNA binding] GO:0001652[granular component] GO:0003676[nucleic acid binding] GO:0003682[chromatin binding] GO:0003713[transcription coactivator activity] GO:0003723[RNA binding] GO:0004860[protein kinase inhibitor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005925[focal adhesion] GO:0006281[DNA repair] GO:0006334[nucleosome assembly] GO:0006338[chromatin remodeling] GO:0006407[rRNA export from nucleus] GO:0006886[intracellular protein transport] GO:0006913[nucleocytoplasmic transport] GO:0007098[centrosome cycle] GO:0007165[signal transduction] GO:0008104[protein localization] GO:0008284[positive regulation of cell population proliferation] GO:0008285[negative regulation of cell population proliferation] GO:0010824[regulation of centrosome duplication] GO:0010826[negative regulation of centrosome duplication] GO:0016020[membrane] GO:0019843[rRNA binding] GO:0019901[protein kinase binding] GO:0030957[Tat protein binding] GO:0031616[spindle pole centrosome] GO:0032071[regulation of endodeoxyribonuclease activity] GO:0032991[protein-containing complex] GO:0032993[protein-DNA complex] GO:0034644[cellular response to UV] GO:0042255[ribosome assembly] GO:0042273[ribosomal large subunit biogenesis] GO:0042274[ribosomal small subunit biogenesis] GO:0042393[histone binding] GO:0042803[protein homodimerization activity] GO:0043023[ribosomal large subunit binding] GO:0043024[ribosomal small subunit binding] GO:0043066[negative regulation of apoptotic process] GO:0044387[negative regulation of protein kinase activity by regulation of protein phosphorylation] GO:0045727[positive regulation of translation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046599[regulation of centriole replication] GO:0051059[NF-kappaB binding] GO:0051082[unfolded protein binding] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060699[regulation of endoribonuclease activity] GO:0060735[regulation of eIF2 alpha phosphorylation by dsRNA] GO:0090398[cellular senescence] GO:0140297[DNA-binding transcription factor binding] GO:0140693[molecular condensate scaffold activity] GO:1902629[regulation of mRNA stability involved in cellular response to UV] GO:1902751[positive regulation of cell cycle G2/M phase transition] GO:1990904[ribonucleoprotein complex]
A0A140VJQ2 [Target identity:100%; Query identity:100%] Testicular tissue protein Li 128
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000055[ribosomal large subunit export from nucleus] GO:0000056[ribosomal small subunit export from nucleus] GO:0001046[core promoter sequence-specific DNA binding] GO:0001652[granular component] GO:0003676[nucleic acid binding] GO:0003682[chromatin binding] GO:0003713[transcription coactivator activity] GO:0003723[RNA binding] GO:0004860[protein kinase inhibitor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005925[focal adhesion] GO:0006281[DNA repair] GO:0006334[nucleosome assembly] GO:0006338[chromatin remodeling] GO:0006407[rRNA export from nucleus] GO:0006886[intracellular protein transport] GO:0006913[nucleocytoplasmic transport] GO:0007098[centrosome cycle] GO:0007165[signal transduction] GO:0008104[protein localization] GO:0008284[positive regulation of cell population proliferation] GO:0008285[negative regulation of cell population proliferation] GO:0010824[regulation of centrosome duplication] GO:0010826[negative regulation of centrosome duplication] GO:0016020[membrane] GO:0019843[rRNA binding] GO:0019901[protein kinase binding] GO:0030957[Tat protein binding] GO:0031616[spindle pole centrosome] GO:0032071[regulation of endodeoxyribonuclease activity] GO:0032991[protein-containing complex] GO:0032993[protein-DNA complex] GO:0034644[cellular response to UV] GO:0042255[ribosome assembly] GO:0042273[ribosomal large subunit biogenesis] GO:0042274[ribosomal small subunit biogenesis] GO:0042393[histone binding] GO:0042803[protein homodimerization activity] GO:0043023[ribosomal large subunit binding] GO:0043024[ribosomal small subunit binding] GO:0043066[negative regulation of apoptotic process] GO:0044387[negative regulation of protein kinase activity by regulation of protein phosphorylation] GO:0045727[positive regulation of translation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046599[regulation of centriole replication] GO:0051059[NF-kappaB binding] GO:0051082[unfolded protein binding] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060699[regulation of endoribonuclease activity] GO:0060735[regulation of eIF2 alpha phosphorylation by dsRNA] GO:0090398[cellular senescence] GO:0140297[DNA-binding transcription factor binding] GO:0140693[molecular condensate scaffold activity] GO:1902629[regulation of mRNA stability involved in cellular response to UV] GO:1902751[positive regulation of cell cycle G2/M phase transition] GO:1990904[ribonucleoprotein complex]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Frameshift Mutations COSMIC Translocations Disease related genes Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000055[ribosomal large subunit export from nucleus] GO:0000056[ribosomal small subunit export from nucleus] GO:0001046[core promoter sequence-specific DNA binding] GO:0001652[granular component] GO:0003676[nucleic acid binding] GO:0003682[chromatin binding] GO:0003713[transcription coactivator activity] GO:0003723[RNA binding] GO:0004860[protein kinase inhibitor activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005730[nucleolus] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005829[cytosol] GO:0005856[cytoskeleton] GO:0005925[focal adhesion] GO:0006281[DNA repair] GO:0006334[nucleosome assembly] GO:0006338[chromatin remodeling] GO:0006407[rRNA export from nucleus] GO:0006886[intracellular protein transport] GO:0006913[nucleocytoplasmic transport] GO:0007098[centrosome cycle] GO:0007165[signal transduction] GO:0008104[protein localization] GO:0008284[positive regulation of cell population proliferation] GO:0008285[negative regulation of cell population proliferation] GO:0010824[regulation of centrosome duplication] GO:0010826[negative regulation of centrosome duplication] GO:0016020[membrane] GO:0019843[rRNA binding] GO:0019901[protein kinase binding] GO:0030957[Tat protein binding] GO:0031616[spindle pole centrosome] GO:0032071[regulation of endodeoxyribonuclease activity] GO:0032991[protein-containing complex] GO:0032993[protein-DNA complex] GO:0034644[cellular response to UV] GO:0042255[ribosome assembly] GO:0042273[ribosomal large subunit biogenesis] GO:0042274[ribosomal small subunit biogenesis] GO:0042393[histone binding] GO:0042803[protein homodimerization activity] GO:0043023[ribosomal large subunit binding] GO:0043024[ribosomal small subunit binding] GO:0043066[negative regulation of apoptotic process] GO:0044387[negative regulation of protein kinase activity by regulation of protein phosphorylation] GO:0045727[positive regulation of translation] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046599[regulation of centriole replication] GO:0051059[NF-kappaB binding] GO:0051082[unfolded protein binding] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060699[regulation of endoribonuclease activity] GO:0060735[regulation of eIF2 alpha phosphorylation by dsRNA] GO:0090398[cellular senescence] GO:0140297[DNA-binding transcription factor binding] GO:0140693[molecular condensate scaffold activity] GO:1902629[regulation of mRNA stability involved in cellular response to UV] GO:1902751[positive regulation of cell cycle G2/M phase transition] GO:1990904[ribonucleoprotein complex]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Frameshift Mutations COSMIC Translocations Human disease related genes Cancers Cancers of haematopoietic and lymphoid tissues Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
