Single cell type - UTS2R - The Human Protein Atlas

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	UTS2R
Gene descriptionⁱ Full gene name according to HGNC.	Urotensin 2 receptor
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s).	G-protein coupled receptors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type expression clusterⁱ The RNA data was used to cluster genes according to their expression across single cell types. Clusters contain genes that have similar expression patterns, and each cluster has been manually annotated to describe common features in terms of function and specificity.	Plasma cells - Humoral immune response (mainly)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Not detected
Tau specificity scoreⁱ Tau specificity score is a numerical indicator of the specificity of the gene expression across cells or tissues. The value ranges from 0 and 1, where 0 indicates identical expression across all cells/tissue types, while 1 indicates expression in a single cell/tissue type.	Not detected
Brain cluster specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell cluster types based on snRNA-seq data from brain samples. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. "cell type" refer to one of the 34 cluster names used to summarize the 2.5 million cells included in the brain cell representation.	Not detected
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected.	Immune cell enhanced (neutrophil)
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); neXtProt protein existence (neXtProt evidence);and a Human Protein Atlas antibody- or RNA based score (HPA evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable.	Evidence at protein level

ASSAYSⁱ

Single cell type

Cell type enrichment

Single nuclei - Brain

Immune cells

Expression clustering

SINGLE CELL TYPESⁱ A summary of normalized single cell RNA (nTPM) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types RNA single cell type specificity: Not detected

TISSUE CELL TYPEⁱ The tissue cell type section provides a cell type specificity prediction for all protein coding genes. More information on the data available can be found here and a description of the analysis here.
	Core cell typesⁱ The core cell type table displays data for a panel of eight cell types that are found in many tissues. Colored dots indicate that the selected gene has core cell type specificity in the indicated tissue. Grey dots indicate that cell type is present within that tissue, but the selected gene is not predicted to be enriched there. Category Alphabetical Enrichment Tissue specific cell typesⁱ This plot shows the enrichment score of the selected gene in all non-core cell types found within the profiled tissues, allowing comparisons between different cell types within different tissues. An enlarged symbol indicates classification of the gene as cell type enriched in the corresponding cell type.

SINGLE NUCLEI BRAINⁱ

Single nuclei cluster types

RNA brain cluster specificity: Not detected

IMMUNE CELL TYPE EXPRESSION (RNA)ⁱ Blood cell type expression overview shows RNA-seq data from three different sources: Internally generated Human Protein Atlas (HPA) data, as well as data generated by (Monaco et al) and (Schmiedel et al). Color-coding is based on blood cell type lineages, including B-cells, T-cells, NK-cells, monocytes, granulocytes and dendritic cells as well as total PBMC. To access sample data, click on tissue name or bar.
HPA datasetⁱ The resulting transcript expression values calculated as nTPM, resulting from the internal normalization pipeline for 18 immune cell types and total peripheral blood mononuclear cells (PBMC). Lineage Expression Alphabetical Immune cell type specificity: Immune cell enhanced (neutrophil)
Monaco datasetⁱ The transcript expression values (nTPM) resulting from the internal normalization pipeline are visualized for 29 blood cell types and total peripheral blood mononuclear cells (PBMC) from Monaco et al. Lineage Expression Alphabetical
Schmiedel datasetⁱ Transcript Per Million (TPM) values are visualized for 15 blood cell types from the Schmiedel et al. dataset. Lineage Expression Alphabetical

EXPRESSION CLUSTERING & CORRELATIONⁱ

SINGLE CELL TYPE

UTS2R is part of cluster 23 Plasma cells - Humoral immune response with confidenceⁱ 1
80 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
IGKJ3	Immunoglobulin kappa joining 3	0.6226	61
IGLV2-8	Immunoglobulin lambda variable 2-8	0.6213	23
IGHJ1	Immunoglobulin heavy joining 1	0.6137	61
IGKV2-24	Immunoglobulin kappa variable 2-24	0.6060	61
IGKV2D-24	Immunoglobulin kappa variable 2D-24 (non-functional)	0.5997	23
IGLV7-46	Immunoglobulin lambda variable 7-46	0.5874	23
IGLV5-45	Immunoglobulin lambda variable 5-45	0.5849	23
EHMT1	Euchromatic histone lysine methyltransferase 1	0.5767	23
IGHV3-43	Immunoglobulin heavy variable 3-43	0.5767	23
IGHV6-1	Immunoglobulin heavy variable 6-1	0.5759	23
IGHV3-66	Immunoglobulin heavy variable 3-66	0.5684	61
IGKV6D-21	Immunoglobulin kappa variable 6D-21 (non-functional)	0.5551	61
IGHV3-15	Immunoglobulin heavy variable 3-15	0.5521	23
TXNDC11	Thioredoxin domain containing 11	0.5509	23
IGLV1-44	Immunoglobulin lambda variable 1-44	0.5484	23

IMMUNE CELLS

UTS2R is part of cluster 20 Non-specific - DNA binding with confidenceⁱ 1
266 genes in cluster

Go to interactive expression cluster page

15 nearest neighbours based on single cell RNA expression

Neighbourⁱ Gene name according to HGNC.	Descriptionⁱ Gene description according to HGNC.	Correlationⁱ Correlation between the selected gene and neighboring gene. Correlation is calculated as Spearman correlation in PCA space based on the RNA-seq expression data.	Clusterⁱ ID of the expression cluster of the neighboring gene.
CREBBP	CREB binding protein	1.0000	20
SP1	Sp1 transcription factor	0.9762	35
OR5AS1	Olfactory receptor family 5 subfamily AS member 1	0.9762	20
ATP23	ATP23 metallopeptidase and ATP synthase assembly factor homolog	0.9762	20
SPACA7	Sperm acrosome associated 7	0.9762	20
KIF13A	Kinesin family member 13A	0.9762	20
OPHN1	Oligophrenin 1	0.9762	20
EP300	E1A binding protein p300	0.9524	20
ELAVL2	ELAV like RNA binding protein 2	0.9524	20
CTCFL	CCCTC-binding factor like	0.9524	20
GFAP	Glial fibrillary acidic protein	0.9524	20
PKD2L2	Polycystin 2 like 2, transient receptor potential cation channel	0.9524	35
ETFBKMT	Electron transfer flavoprotein subunit beta lysine methyltransferase	0.9524	20
CYP1A2	Cytochrome P450 family 1 subfamily A member 2	0.9524	20
TESK2	Testis associated actin remodelling kinase 2	0.9524	20