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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
20
Cytoband
p12.3
Chromosome location (bp)
8077251 - 8968360
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Catalyzes the hydrolysis of 1-phosphatidylinositol 4,5-bisphosphate into diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) and mediates intracellular signaling downstream of G protein-coupled receptors 1. Regulates the function of the endothelial barrier....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hydrolase, Transducer
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Lipid degradation, Lipid metabolism
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Hydrolases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Potential drug targets Human disease related genes Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000086[G2/M transition of mitotic cell cycle] GO:0000785[chromatin] GO:0004435[phosphatidylinositol phospholipase C activity] GO:0004629[phospholipase C activity] GO:0005096[GTPase activator activity] GO:0005246[calcium channel regulator activity] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005521[lamin binding] GO:0005546[phosphatidylinositol-4,5-bisphosphate binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006629[lipid metabolic process] GO:0007165[signal transduction] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007200[phospholipase C-activating G protein-coupled receptor signaling pathway] GO:0007207[phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway] GO:0007213[G protein-coupled acetylcholine receptor signaling pathway] GO:0007215[glutamate receptor signaling pathway] GO:0007420[brain development] GO:0007612[learning] GO:0007613[memory] GO:0008081[phosphoric diester hydrolase activity] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0010243[response to organonitrogen compound] GO:0016020[membrane] GO:0016042[lipid catabolic process] GO:0016607[nuclear speck] GO:0016787[hydrolase activity] GO:0019899[enzyme binding] GO:0021987[cerebral cortex development] GO:0031161[phosphatidylinositol catabolic process] GO:0031965[nuclear membrane] GO:0032024[positive regulation of insulin secretion] GO:0032735[positive regulation of interleukin-12 production] GO:0032957[inositol trisphosphate metabolic process] GO:0032991[protein-containing complex] GO:0034284[response to monosaccharide] GO:0035556[intracellular signal transduction] GO:0035722[interleukin-12-mediated signaling pathway] GO:0035723[interleukin-15-mediated signaling pathway] GO:0040019[positive regulation of embryonic development] GO:0042802[identical protein binding] GO:0043434[response to peptide hormone] GO:0043539[protein serine/threonine kinase activator activity] GO:0045444[fat cell differentiation] GO:0045663[positive regulation of myoblast differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0046330[positive regulation of JNK cascade] GO:0046488[phosphatidylinositol metabolic process] GO:0048009[insulin-like growth factor receptor signaling pathway] GO:0048015[phosphatidylinositol-mediated signaling] GO:0048639[positive regulation of developmental growth] GO:0051726[regulation of cell cycle] GO:0060466[activation of meiosis involved in egg activation] GO:0070062[extracellular exosome] GO:0070498[interleukin-1-mediated signaling pathway] GO:0080154[regulation of fertilization] GO:0098978[glutamatergic synapse] GO:0098982[GABA-ergic synapse] GO:0099103[channel activator activity] GO:0099105[ion channel modulating, G protein-coupled receptor signaling pathway] GO:0099107[ion channel regulator activity involved in G protein-coupled receptor signaling pathway] GO:0099170[postsynaptic modulation of chemical synaptic transmission] GO:0099178[regulation of retrograde trans-synaptic signaling by endocanabinoid] GO:0099524[postsynaptic cytosol] GO:0110165[cellular anatomical entity] GO:1900087[positive regulation of G1/S transition of mitotic cell cycle] GO:1902618[cellular response to fluoride] GO:1903140[regulation of establishment of endothelial barrier] GO:1904117[cellular response to vasopressin] GO:1904637[cellular response to ionomycin] GO:1905631[cellular response to glyceraldehyde] GO:1990806[ligand-gated ion channel signaling pathway] GO:2000344[positive regulation of acrosome reaction] GO:2000438[negative regulation of monocyte extravasation] GO:2000560[positive regulation of CD24 production]
Enzymes ENZYME proteins Hydrolases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Potential drug targets Human disease related genes Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000086[G2/M transition of mitotic cell cycle] GO:0000785[chromatin] GO:0004435[phosphatidylinositol phospholipase C activity] GO:0004629[phospholipase C activity] GO:0005096[GTPase activator activity] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005546[phosphatidylinositol-4,5-bisphosphate binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006629[lipid metabolic process] GO:0007165[signal transduction] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007213[G protein-coupled acetylcholine receptor signaling pathway] GO:0007215[glutamate receptor signaling pathway] GO:0007420[brain development] GO:0007613[memory] GO:0008081[phosphoric diester hydrolase activity] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0016020[membrane] GO:0016042[lipid catabolic process] GO:0016607[nuclear speck] GO:0016787[hydrolase activity] GO:0019899[enzyme binding] GO:0021987[cerebral cortex development] GO:0031965[nuclear membrane] GO:0032735[positive regulation of interleukin-12 production] GO:0035556[intracellular signal transduction] GO:0035722[interleukin-12-mediated signaling pathway] GO:0035723[interleukin-15-mediated signaling pathway] GO:0040019[positive regulation of embryonic development] GO:0042802[identical protein binding] GO:0045663[positive regulation of myoblast differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0046330[positive regulation of JNK cascade] GO:0046488[phosphatidylinositol metabolic process] GO:0048009[insulin-like growth factor receptor signaling pathway] GO:0048015[phosphatidylinositol-mediated signaling] GO:0048639[positive regulation of developmental growth] GO:0051726[regulation of cell cycle] GO:0060466[activation of meiosis involved in egg activation] GO:0070062[extracellular exosome] GO:0070498[interleukin-1-mediated signaling pathway] GO:0080154[regulation of fertilization] GO:0110165[cellular anatomical entity] GO:1900087[positive regulation of G1/S transition of mitotic cell cycle] GO:2000344[positive regulation of acrosome reaction] GO:2000438[negative regulation of monocyte extravasation] GO:2000560[positive regulation of CD24 production]
Enzymes ENZYME proteins Hydrolases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Potential drug targets Human disease related genes Nervous system diseases Epilepsy Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000086[G2/M transition of mitotic cell cycle] GO:0000785[chromatin] GO:0004435[phosphatidylinositol phospholipase C activity] GO:0004629[phospholipase C activity] GO:0005096[GTPase activator activity] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005546[phosphatidylinositol-4,5-bisphosphate binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006629[lipid metabolic process] GO:0007165[signal transduction] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007213[G protein-coupled acetylcholine receptor signaling pathway] GO:0007215[glutamate receptor signaling pathway] GO:0007420[brain development] GO:0007613[memory] GO:0008081[phosphoric diester hydrolase activity] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0016020[membrane] GO:0016042[lipid catabolic process] GO:0016607[nuclear speck] GO:0016787[hydrolase activity] GO:0019899[enzyme binding] GO:0021987[cerebral cortex development] GO:0031965[nuclear membrane] GO:0032735[positive regulation of interleukin-12 production] GO:0035556[intracellular signal transduction] GO:0035722[interleukin-12-mediated signaling pathway] GO:0035723[interleukin-15-mediated signaling pathway] GO:0040019[positive regulation of embryonic development] GO:0042802[identical protein binding] GO:0045663[positive regulation of myoblast differentiation] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0046330[positive regulation of JNK cascade] GO:0046488[phosphatidylinositol metabolic process] GO:0048009[insulin-like growth factor receptor signaling pathway] GO:0048015[phosphatidylinositol-mediated signaling] GO:0048639[positive regulation of developmental growth] GO:0051726[regulation of cell cycle] GO:0060466[activation of meiosis involved in egg activation] GO:0070062[extracellular exosome] GO:0070498[interleukin-1-mediated signaling pathway] GO:0080154[regulation of fertilization] GO:0110165[cellular anatomical entity] GO:1900087[positive regulation of G1/S transition of mitotic cell cycle] GO:2000344[positive regulation of acrosome reaction] GO:2000438[negative regulation of monocyte extravasation] GO:2000560[positive regulation of CD24 production]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004435[phosphatidylinositol phospholipase C activity] GO:0005509[calcium ion binding] GO:0016042[lipid catabolic process]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
A0A0D9SF51 [Direct mapping] Phosphoinositide phospholipase C
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
A0A0D9SG17 [Direct mapping] Phosphoinositide phospholipase C
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Nervous system diseases Epilepsy Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
