Expression of RPS17 in urothelial cancer

BLADDER UROTHELIAL CARCINOMA (TCGA) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

RPS17 is not prognostic in Bladder Urothelial Carcinoma (TCGA)

Stage:

Survival analysis

Current cut offⁱ :

Best expression cut offⁱ : 1973.01

Median expressionⁱ : N/A

Median follow up timeⁱ : N/A

P scoreⁱ N/A

5-year survival highⁱ N/A

5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average pTPM

2512.4

Number of samples

169

Samples

Sample	Description	pTPM
TCGA-BL-A13J-01A	65 years, male, white, stage:Stage IV, dead, 81 days	8521.1
TCGA-ZF-AA5N-01A	62 years, female, white, stage:Stage IV, dead, 168 days	6107.0
TCGA-XF-AAN1-01A	75 years, female, stage:Stage III, dead, 941 days	5505.4
TCGA-FJ-A871-01A	49 years, male, white, stage:Stage III, dead, 272 days	5436.2
TCGA-BT-A0S7-01A	75 years, male, white, stage:Stage III, dead, 200 days	5017.2
TCGA-BT-A20V-01A	59 years, female, black or african american, stage:Stage IV, dead, 154 days	4967.1
TCGA-UY-A78N-01A	80 years, male, white, stage:Stage IV, dead, 2641 days	4729.8
TCGA-XF-AAN8-01A	74 years, female, white, stage:Stage III, dead, 118 days	4624.5
TCGA-GU-A42Q-01A	67 years, male, white, stage:Stage III, dead, 344 days	4590.0
TCGA-DK-AA6Q-01A	61 years, female, white, stage:Stage IV, dead, 413 days	4588.2
TCGA-ZF-AA4N-01A	74 years, male, white, stage:Stage II, dead, 88 days	4582.3
TCGA-FJ-A3ZE-01A	65 years, male, white, stage:Stage IV, dead, 324 days	4538.9
TCGA-XF-AAMH-01A	80 years, male, white, stage:Stage IV, dead, 344 days	4176.6
TCGA-G2-A2EO-01A	69 years, male, white, stage:Stage III, dead, 1804 days	4118.3
TCGA-FD-A43Y-01A	65 years, male, white, stage:Stage III, dead, 474 days	4083.3
TCGA-ZF-AA54-01A	71 years, male, white, stage:Stage III, dead, 590 days	4036.1
TCGA-UY-A78M-01A	81 years, female, asian, stage:Stage IV, dead, 690 days	3974.5
TCGA-E5-A4TZ-01A	64 years, male, white, stage:Stage IV, dead, 467 days	3965.4
TCGA-FD-A3B4-01A	55 years, female, black or african american, stage:Stage III, dead, 510 days	3932.9
TCGA-FD-A6TF-01A	80 years, female, white, stage:Stage IV, dead, 69 days	3919.7
TCGA-CF-A47T-01A	58 years, female, asian, stage:Stage II, dead, 385 days	3865.5
TCGA-G2-A2ES-01A	85 years, male, white, stage:Stage II, dead, 1004 days	3850.5
TCGA-BT-A20N-01A	72 years, male, stage:Stage III, dead, 795 days	3786.8
TCGA-GC-A3BM-01A	70 years, male, white, stage:Stage II, dead, 651 days	3773.4
TCGA-2F-A9KP-01A	66 years, male, white, stage:Stage IV, dead, 364 days	3669.2
TCGA-FD-A62O-01A	74 years, male, white, stage:Stage IV, dead, 216 days	3614.9
TCGA-XF-A9SH-01A	65 years, female, asian, stage:Stage II, dead, 1971 days	3584.2
TCGA-G2-A3IB-01A	66 years, male, black or african american, stage:Stage II, dead, 220 days	3555.2
TCGA-DK-A1AB-01A	74 years, female, white, stage:Stage IV, dead, 508 days	3549.2
TCGA-ZF-AA4U-01A	70 years, male, white, stage:Stage III, dead, 262 days	3543.9
TCGA-2F-A9KO-01A	63 years, male, white, stage:Stage IV, dead, 734 days	3526.9
TCGA-4Z-AA86-01A	66 years, male, black or african american, stage:Stage IV, dead, 311 days	3464.8
TCGA-ZF-A9RN-01A	67 years, female, white, stage:Stage III, dead, 615 days	3458.1
TCGA-4Z-AA7N-01A	65 years, male, white, stage:Stage III, dead, 1367 days	3433.4
TCGA-CU-A0YO-01A	84 years, male, white, stage:Stage IV, dead, 149 days	3430.7
TCGA-G2-A2EC-01A	58 years, female, black or african american, stage:Stage II, dead, 696 days	3425.9
TCGA-XF-AAMW-01A	79 years, female, white, stage:Stage IV, dead, 253 days	3407.3
TCGA-5N-A9KM-01A	73 years, female, white, stage:Stage III, dead, 530 days	3356.1
TCGA-ZF-A9RD-01A	75 years, female, white, stage:Stage IV, dead, 408 days	3340.1
TCGA-BT-A20W-01A	71 years, male, white, stage:Stage II, dead, 254 days	3295.7
TCGA-FD-A5BX-01A	82 years, male, white, stage:Stage IV, dead, 173 days	3220.7
TCGA-K4-A4AC-01A	83 years, male, white, stage:Stage II, dead, 278 days	3211.3
TCGA-FJ-A3Z9-01A	72 years, male, white, stage:'--, dead, 385 days	3192.6
TCGA-K4-A5RI-01A	67 years, female, white, stage:Stage III, dead, 356 days	3181.0
TCGA-FD-A3B5-01A	86 years, male, black or african american, stage:Stage IV, dead, 272 days	3090.6
TCGA-FD-A3SJ-01A	59 years, male, white, stage:Stage IV, dead, 739 days	3079.5
TCGA-E7-A4XJ-01A	66 years, male, asian, stage:Stage II, dead, 68 days	3057.9
TCGA-GU-AATQ-01A	68 years, male, white, stage:Stage III, dead, 213 days	3020.8
TCGA-GU-A762-01A	87 years, male, white, stage:Stage IV, dead, 232 days	2988.4
TCGA-FD-A5BV-01A	47 years, female, white, stage:Stage III, dead, 163 days	2979.7
TCGA-ZF-AA56-01A	79 years, female, white, stage:Stage III, dead, 259 days	2978.8
TCGA-HQ-A5ND-01A	78 years, male, stage:Stage IV, dead, 274 days	2927.2
TCGA-XF-AAN7-01A	60 years, male, white, stage:Stage IV, dead, 565 days	2909.8
TCGA-YC-A9TC-01A	71 years, male, white, stage:Stage IV, dead, 20 days	2906.6
TCGA-BT-A3PK-01A	80 years, male, white, stage:Stage II, dead, 303 days	2896.7
TCGA-XF-A8HI-01A	57 years, female, white, stage:Stage IV, dead, 544 days	2892.2
TCGA-BT-A20J-01A	75 years, male, white, stage:Stage II, dead, 579 days	2833.0
TCGA-DK-AA6W-01A	78 years, male, white, stage:Stage II, dead, 415 days	2829.8
TCGA-E7-A97P-01A	73 years, male, asian, stage:Stage II, dead, 437 days	2820.4
TCGA-XF-A9SZ-01A	79 years, male, white, stage:Stage IV, dead, 859 days	2819.4
TCGA-XF-AAN0-01A	68 years, male, white, stage:Stage IV, dead, 1718 days	2805.8
TCGA-BT-A20Q-01A	73 years, male, white, stage:Stage IV, dead, 593 days	2791.2
TCGA-CU-A72E-01A	76 years, male, white, stage:Stage IV, dead, 413 days	2788.4
TCGA-DK-A3IU-01A	58 years, male, white, stage:Stage II, dead, 706 days	2787.2
TCGA-DK-A1A3-01A	60 years, male, white, stage:Stage IV, dead, 665 days	2769.4
TCGA-XF-A8HC-01A	79 years, male, asian, stage:Stage IV, dead, 200 days	2743.8
TCGA-4Z-AA7Q-01A	79 years, male, white, stage:Stage III, dead, 510 days	2709.8
TCGA-DK-AA75-01A	82 years, male, white, stage:Stage III, dead, 340 days	2704.8
TCGA-4Z-AA7R-01A	73 years, male, black or african american, stage:Stage IV, dead, 522 days	2681.8
TCGA-FD-A6TH-01A	63 years, male, white, stage:Stage IV, dead, 131 days	2675.7
TCGA-CU-A0YN-01A	60 years, male, white, stage:Stage III, dead, 393 days	2656.0
TCGA-UY-A78K-01A	60 years, male, white, stage:Stage IV, dead, 536 days	2606.0
TCGA-FD-A3B6-01A	75 years, male, white, stage:Stage II, dead, 1005 days	2603.6
TCGA-FD-A6TG-01A	73 years, male, white, stage:Stage IV, dead, 93 days	2594.3
TCGA-GV-A3JV-01A	66 years, male, white, stage:Stage IV, dead, 434 days	2589.0
TCGA-DK-A2I2-01A	63 years, female, white, stage:Stage IV, dead, 237 days	2578.1
TCGA-FD-A3N5-01A	69 years, male, black or african american, stage:Stage II, dead, 685 days	2567.2
TCGA-XF-AAML-01A	75 years, male, white, stage:Stage II, dead, 232 days	2540.1
TCGA-FD-A6TD-01A	77 years, male, white, stage:Stage III, dead, 386 days	2519.5
TCGA-FD-A3SS-01A	66 years, male, white, stage:Stage IV, dead, 391 days	2474.1
TCGA-XF-AAMT-01A	75 years, female, white, stage:Stage IV, dead, 90 days	2449.0
TCGA-XF-AAN2-01A	73 years, male, white, stage:Stage II, dead, 1869 days	2443.2
TCGA-GU-A767-01A	81 years, male, white, stage:Stage IV, dead, 144 days	2417.0
TCGA-ZF-A9R0-01A	82 years, male, white, stage:Stage III, dead, 680 days	2413.7
TCGA-FD-A3SQ-01A	62 years, male, white, stage:Stage IV, dead, 1423 days	2366.8
TCGA-DK-A3IQ-01A	74 years, male, white, stage:Stage III, dead, 539 days	2366.8
TCGA-FD-A62P-01A	76 years, male, white, stage:Stage II, dead, 191 days	2364.2
TCGA-2F-A9KW-01A	67 years, female, white, stage:Stage III, dead, 254 days	2328.7
TCGA-G2-AA3C-01A	66 years, male, white, stage:Stage IV, dead, 211 days	2320.2
TCGA-CU-A0YR-01A	83 years, male, white, stage:Stage IV, dead, 460 days	2309.4
TCGA-CF-A9FL-01A	85 years, male, asian, stage:Stage III, dead, 565 days	2270.2
TCGA-5N-A9KI-01A	76 years, female, white, stage:Stage III, dead, 76 days	2268.3
TCGA-BT-A0YX-01A	70 years, female, white, stage:Stage III, dead, 400 days	2248.3
TCGA-BT-A20X-01A	56 years, male, white, stage:Stage IV, dead, 251 days	2236.1
TCGA-BT-A3PH-01A	76 years, male, white, stage:Stage IV, dead, 142 days	2208.6
TCGA-CU-A5W6-01A	70 years, male, white, stage:Stage III, dead, 56 days	2195.1
TCGA-E7-A3X6-01A	70 years, male, white, stage:Stage II, dead, 904 days	2176.0
TCGA-C4-A0F7-01A	77 years, male, stage:Stage IV, dead, 62 days	2161.4
TCGA-XF-A8HF-01A	80 years, male, white, stage:Stage III, dead, 2954 days	2160.2
TCGA-XF-AAMZ-01A	81 years, female, white, stage:Stage IV, dead, 1348 days	2141.2
TCGA-FD-A3B7-01A	66 years, male, black or african american, stage:Stage III, dead, 122 days	2111.4
TCGA-DK-A3IK-01A	87 years, male, white, stage:Stage IV, dead, 146 days	2080.1
TCGA-DK-A1A5-01A	79 years, male, white, stage:Stage II, dead, 65 days	2073.7
TCGA-XF-A8HH-01A	61 years, female, white, stage:Stage IV, dead, 57 days	2049.7
TCGA-ZF-A9R3-01A	53 years, female, white, stage:Stage II, dead, 949 days	2046.3
TCGA-XF-A9ST-01A	68 years, male, white, stage:Stage III, dead, 128 days	2041.8
TCGA-GV-A3QH-01A	67 years, male, white, stage:Stage II, dead, 258 days	2009.5
TCGA-G2-A3IE-01A	51 years, male, white, stage:Stage II, dead, 612 days	2008.8
TCGA-HQ-A5NE-01A	57 years, male, stage:Stage III, dead, 370 days	1999.4
TCGA-XF-A9SP-01A	59 years, male, white, stage:Stage III, dead, 454 days	1998.4
TCGA-XF-A9SK-01A	65 years, male, white, stage:Stage IV, dead, 486 days	1978.3
TCGA-C4-A0EZ-01A	69 years, female, stage:Stage IV, dead, 273 days	1973.0
TCGA-BT-A2LD-01A	78 years, female, white, stage:Stage IV, dead, 623 days	1954.0
TCGA-4Z-AA82-01A	59 years, male, black or african american, stage:Stage IV, dead, 1556 days	1920.5
TCGA-FD-A5C0-01A	61 years, male, white, stage:Stage IV, dead, 550 days	1908.7
TCGA-S5-A6DX-01A	83 years, male, white, stage:Stage IV, dead, 56 days	1906.9
TCGA-FD-A3B3-01A	74 years, female, white, stage:Stage III, dead, 974 days	1884.9
TCGA-XF-A9T2-01A	54 years, male, white, stage:Stage III, dead, 575 days	1884.6
TCGA-GU-A42R-01A	68 years, male, white, stage:Stage IV, dead, 577 days	1882.1
TCGA-FD-A6TI-01A	73 years, male, white, stage:Stage IV, dead, 294 days	1829.9
TCGA-XF-A8HG-01A	69 years, male, white, stage:Stage III, dead, 467 days	1829.6
TCGA-XF-A9SL-01A	69 years, male, white, stage:Stage IV, dead, 2020 days	1735.8
TCGA-XF-A9SW-01A	85 years, male, white, stage:Stage IV, dead, 362 days	1706.7
TCGA-FD-A3SM-01A	70 years, male, white, stage:Stage IV, dead, 547 days	1687.1
TCGA-BT-A20U-01A	70 years, female, white, stage:Stage III, dead, 455 days	1658.2
TCGA-GV-A3QF-01A	79 years, male, white, stage:Stage IV, dead, 617 days	1635.7
TCGA-GU-AATO-01A	75 years, male, white, stage:Stage IV, dead, 324 days	1622.8
TCGA-BT-A20P-01A	81 years, female, white, stage:Stage III, dead, 544 days	1609.7
TCGA-GC-A3I6-01A	45 years, male, white, stage:Stage III, dead, 630 days	1539.2
TCGA-SY-A9G0-01A	82 years, male, white, stage:Stage IV, dead, 1008 days	1527.2
TCGA-4Z-AA7S-01A	66 years, male, black or african american, stage:Stage III, dead, 1064 days	1525.1
TCGA-DK-AA6L-01A	48 years, male, white, stage:Stage IV, dead, 1163 days	1516.7
TCGA-G2-A2EL-01A	77 years, male, white, stage:Stage II, dead, 819 days	1508.1
TCGA-FD-A5BT-01A	84 years, male, white, stage:Stage III, dead, 328 days	1501.6
TCGA-DK-A3IM-01A	76 years, male, white, stage:Stage III, dead, 248 days	1475.3
TCGA-BL-A3JM-01A	62 years, male, white, stage:Stage III, dead, 205 days	1463.2
TCGA-FD-A3SO-01A	68 years, male, white, stage:Stage IV, dead, 168 days	1423.1
TCGA-XF-A9SU-01A	74 years, female, white, stage:Stage IV, dead, 182 days	1387.7
TCGA-DK-A3IL-01A	79 years, female, white, stage:Stage IV, dead, 413 days	1378.0
TCGA-BT-A2LB-01A	73 years, female, white, stage:Stage III, dead, 492 days	1369.5
TCGA-XF-A9T8-01A	64 years, male, white, stage:Stage III, dead, 418 days	1365.0
TCGA-XF-A9SV-01A	82 years, male, white, stage:Stage IV, dead, 388 days	1332.6
TCGA-XF-AAN4-01A	77 years, female, white, stage:Stage III, dead, 823 days	1262.5
TCGA-XF-A9SX-01A	63 years, female, white, stage:Stage IV, dead, 719 days	1245.4
TCGA-BL-A13I-01A	57 years, female, white, stage:Stage III, dead, 223 days	1239.9
TCGA-DK-A2HX-01A	80 years, female, white, stage:Stage IV, dead, 1420 days	1227.0
TCGA-4Z-AA80-01A	73 years, male, white, stage:Stage II, dead, 19 days	1226.3
TCGA-ZF-A9RE-01A	78 years, female, white, stage:Stage II, dead, 106 days	1199.0
TCGA-XF-AAME-01A	64 years, female, white, stage:Stage II, dead, 2828 days	1144.9
TCGA-2F-A9KR-01A	59 years, female, stage:Stage III, dead, 3183 days	1106.1
TCGA-FD-A3SR-01A	68 years, male, white, stage:Stage IV, dead, 602 days	1095.3
TCGA-ZF-AA4T-01A	65 years, male, white, stage:Stage IV, dead, 599 days	1088.3
TCGA-GV-A40E-01A	75 years, male, white, stage:Stage II, dead, 261 days	1059.1
TCGA-ZF-AA52-01A	70 years, male, white, stage:Stage III, dead, 1077 days	1037.5
TCGA-DK-A3IN-01A	72 years, male, white, stage:Stage III, dead, 250 days	1035.2
TCGA-XF-A9SJ-01A	83 years, male, white, stage:Stage IV, dead, 98 days	1033.2
TCGA-4Z-AA81-01A	80 years, male, white, stage:Stage II, dead, 1270 days	1031.4
TCGA-XF-AAMJ-01A	70 years, male, asian, stage:Stage III, dead, 1670 days	973.9
TCGA-ZF-AA4R-01A	67 years, male, white, stage:Stage IV, dead, 1036 days	924.2
TCGA-BT-A20O-01A	75 years, male, white, stage:Stage III, dead, 370 days	879.5
TCGA-FD-A5BZ-01A	77 years, female, white, stage:Stage IV, dead, 835 days	876.8
TCGA-XF-AAMX-01A	87 years, female, black or african american, stage:Stage III, dead, 206 days	827.2
TCGA-E7-A541-01A	66 years, male, white, stage:Stage II, dead, 778 days	814.3
TCGA-FD-A3SL-01A	60 years, male, white, stage:Stage IV, dead, 712 days	785.2
TCGA-GU-A42P-01A	72 years, male, white, stage:Stage IV, dead, 332 days	741.3
TCGA-FD-A62S-01A	60 years, female, black or african american, stage:Stage III, dead, 406 days	647.4
TCGA-DK-A3X2-01A	85 years, male, white, stage:Stage IV, dead, 547 days	645.3
TCGA-BT-A20T-01A	63 years, male, white, stage:Stage IV, dead, 453 days	554.1
TCGA-ZF-A9R9-01A	58 years, male, white, stage:Stage IV, dead, 864 days	349.8
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UROTHELIAL CANCER - Protein expressionⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.	Antibody HPA055060
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Urothelial carcinoma, High grade
Urothelial carcinoma, NOS
Urothelial carcinoma, Low grade