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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
q43
Chromosome location (bp)
240767636 - 241357374
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
GTPase activator component of the RGS7-GNB5 complex that regulates G protein-coupled receptor signaling cascades 1,2,3. The RGS7-GNB5 complex acts as an inhibitor signal transduction by promoting the GTPase activity of G protein alpha subunits, such as GNAO1, thereby driving them into their inactive GDP-bound form 4,5. May play a role in synaptic vesicle exocytosis (Probable) 6. Glycine-dependent regulation of the RGS7-GNB5 complex by GPR158 affects mood and cognition via its ability to regulate neuronal excitability in L2/L3 pyramidal neurons of the prefrontal cortex (By similarity). Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling 7....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
GTPase activation, Signal transduction inhibitor
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables G-protein beta-subunit binding activity and GTPase activator activity. Involved in positive regulation of GTPase activity. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P49802 [Direct mapping] Regulator of G-protein signaling 7
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
P49802 [Direct mapping] Regulator of G-protein signaling 7
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
P49802 [Direct mapping] Regulator of G-protein signaling 7
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
P49802 [Direct mapping] Regulator of G-protein signaling 7
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P49802 [Direct mapping] Regulator of G-protein signaling 7
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Q5T3H5 [Direct mapping] Regulator of G-protein-signaling 7
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
B7Z257 [Direct mapping] Regulator of G-protein-signaling 7; cDNA FLJ61685, highly similar to Regulator of G-protein signaling 7
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007186[G protein-coupled receptor signaling pathway] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0009968[negative regulation of signal transduction] GO:0035556[intracellular signal transduction]
A0A8I5KV90 [Direct mapping] Regulator of G-protein-signaling 7
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007186[G protein-coupled receptor signaling pathway] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0009968[negative regulation of signal transduction] GO:0035556[intracellular signal transduction]
A0A8I5KZ23 [Direct mapping] Regulator of G-protein-signaling 7
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007186[G protein-coupled receptor signaling pathway] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0009968[negative regulation of signal transduction] GO:0035556[intracellular signal transduction]
A0A8I5KXW5 [Direct mapping] Regulator of G-protein-signaling 7
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007186[G protein-coupled receptor signaling pathway] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0009968[negative regulation of signal transduction] GO:0035556[intracellular signal transduction]
A0A8I5KVW2 [Direct mapping] Regulator of G-protein-signaling 7
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007186[G protein-coupled receptor signaling pathway] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0009968[negative regulation of signal transduction] GO:0035556[intracellular signal transduction]
B7Z257 [Direct mapping] Regulator of G-protein-signaling 7; cDNA FLJ61685, highly similar to Regulator of G-protein signaling 7
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007186[G protein-coupled receptor signaling pathway] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0009968[negative regulation of signal transduction] GO:0035556[intracellular signal transduction]
A0A8I5KRH6 [Direct mapping] Regulator of G-protein-signaling 7
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007186[G protein-coupled receptor signaling pathway] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0009968[negative regulation of signal transduction] GO:0035556[intracellular signal transduction]
A0A8I5KY39 [Direct mapping] Regulator of G-protein-signaling 7
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SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
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GO:0007186[G protein-coupled receptor signaling pathway] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0009968[negative regulation of signal transduction] GO:0035556[intracellular signal transduction]
A0A8I5QJU0 [Direct mapping] Regulator of G-protein-signaling 7
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007186[G protein-coupled receptor signaling pathway] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0035556[intracellular signal transduction]
A0A8I5KXW5 [Direct mapping] Regulator of G-protein-signaling 7
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007186[G protein-coupled receptor signaling pathway] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0009968[negative regulation of signal transduction] GO:0035556[intracellular signal transduction]
A0A8I5KR27 [Direct mapping] Regulator of G-protein-signaling 7
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007186[G protein-coupled receptor signaling pathway] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0009968[negative regulation of signal transduction] GO:0035556[intracellular signal transduction]
A0A8I5KZ50 [Direct mapping] Regulator of G-protein-signaling 7
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THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
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GO:0007186[G protein-coupled receptor signaling pathway] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0009968[negative regulation of signal transduction] GO:0035556[intracellular signal transduction]
A0A8I5KRS1 [Direct mapping] Regulator of G-protein-signaling 7
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007186[G protein-coupled receptor signaling pathway] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0009968[negative regulation of signal transduction] GO:0035556[intracellular signal transduction]
B7Z257 [Direct mapping] Regulator of G-protein-signaling 7; cDNA FLJ61685, highly similar to Regulator of G-protein signaling 7
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007186[G protein-coupled receptor signaling pathway] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0009968[negative regulation of signal transduction] GO:0035556[intracellular signal transduction]
A0A8I5KXW5 [Direct mapping] Regulator of G-protein-signaling 7
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007186[G protein-coupled receptor signaling pathway] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0009968[negative regulation of signal transduction] GO:0035556[intracellular signal transduction]
P49802 [Direct mapping] Regulator of G-protein signaling 7
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
A0A8I5KUA7 [Direct mapping] Regulator of G-protein-signaling 7
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Show all
GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0009968[negative regulation of signal transduction] GO:0035556[intracellular signal transduction]
A0A8I5KXW5 [Direct mapping] Regulator of G-protein-signaling 7
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Show all
GO:0007186[G protein-coupled receptor signaling pathway] GO:0008277[regulation of G protein-coupled receptor signaling pathway] GO:0009968[negative regulation of signal transduction] GO:0035556[intracellular signal transduction]
P49802 [Direct mapping] Regulator of G-protein signaling 7
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
