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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
X
Cytoband
q28
Chromosome location (bp)
154010506 - 154019902
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Host-virus interaction, Immunity, Innate immunity
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Magnesium, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Transferases Kinases TKL Ser/Thr protein kinases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001959[regulation of cytokine-mediated signaling pathway] GO:0002224[toll-like receptor signaling pathway] GO:0002376[immune system process] GO:0002755[MyD88-dependent toll-like receptor signaling pathway] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004704[NF-kappaB-inducing kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005811[lipid droplet] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0007165[signal transduction] GO:0007250[activation of NF-kappaB-inducing kinase activity] GO:0010008[endosome membrane] GO:0010468[regulation of gene expression] GO:0010556[regulation of macromolecule biosynthetic process] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0019221[cytokine-mediated signaling pathway] GO:0019901[protein kinase binding] GO:0031326[regulation of cellular biosynthetic process] GO:0031663[lipopolysaccharide-mediated signaling pathway] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032481[positive regulation of type I interferon production] GO:0032496[response to lipopolysaccharide] GO:0032991[protein-containing complex] GO:0034134[toll-like receptor 2 signaling pathway] GO:0034142[toll-like receptor 4 signaling pathway] GO:0034162[toll-like receptor 9 signaling pathway] GO:0035556[intracellular signal transduction] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043406[positive regulation of MAP kinase activity] GO:0044093[positive regulation of molecular function] GO:0045087[innate immune response] GO:0046777[protein autophosphorylation] GO:0046982[protein heterodimerization activity] GO:0048583[regulation of response to stimulus] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060337[type I interferon signaling pathway] GO:0070498[interleukin-1-mediated signaling pathway] GO:0070555[response to interleukin-1] GO:0071222[cellular response to lipopolysaccharide] GO:0071345[cellular response to cytokine stimulus] GO:0106310[protein serine kinase activity] GO:1901224[positive regulation of NIK/NF-kappaB signaling] GO:1904996[positive regulation of leukocyte adhesion to vascular endothelial cell]
Enzymes ENZYME proteins Transferases Kinases TKL Ser/Thr protein kinases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001959[regulation of cytokine-mediated signaling pathway] GO:0002224[toll-like receptor signaling pathway] GO:0002376[immune system process] GO:0002755[MyD88-dependent toll-like receptor signaling pathway] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004704[NF-kappaB-inducing kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005811[lipid droplet] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0007165[signal transduction] GO:0007250[activation of NF-kappaB-inducing kinase activity] GO:0007254[JNK cascade] GO:0007568[aging] GO:0010008[endosome membrane] GO:0010468[regulation of gene expression] GO:0010556[regulation of macromolecule biosynthetic process] GO:0016020[membrane] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0019221[cytokine-mediated signaling pathway] GO:0019901[protein kinase binding] GO:0031072[heat shock protein binding] GO:0031326[regulation of cellular biosynthetic process] GO:0031663[lipopolysaccharide-mediated signaling pathway] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032481[positive regulation of type I interferon production] GO:0032496[response to lipopolysaccharide] GO:0032991[protein-containing complex] GO:0034134[toll-like receptor 2 signaling pathway] GO:0034142[toll-like receptor 4 signaling pathway] GO:0034162[toll-like receptor 9 signaling pathway] GO:0034605[cellular response to heat] GO:0035556[intracellular signal transduction] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043406[positive regulation of MAP kinase activity] GO:0044093[positive regulation of molecular function] GO:0045087[innate immune response] GO:0046777[protein autophosphorylation] GO:0046982[protein heterodimerization activity] GO:0048583[regulation of response to stimulus] GO:0048661[positive regulation of smooth muscle cell proliferation] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060337[type I interferon signaling pathway] GO:0070498[interleukin-1-mediated signaling pathway] GO:0070555[response to interleukin-1] GO:0071222[cellular response to lipopolysaccharide] GO:0071345[cellular response to cytokine stimulus] GO:0071456[cellular response to hypoxia] GO:0106310[protein serine kinase activity] GO:1901224[positive regulation of NIK/NF-kappaB signaling] GO:1904996[positive regulation of leukocyte adhesion to vascular endothelial cell]
Enzymes ENZYME proteins Transferases Kinases TKL Ser/Thr protein kinases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166[nucleotide binding] GO:0001959[regulation of cytokine-mediated signaling pathway] GO:0002224[toll-like receptor signaling pathway] GO:0002376[immune system process] GO:0002755[MyD88-dependent toll-like receptor signaling pathway] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004704[NF-kappaB-inducing kinase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005811[lipid droplet] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006468[protein phosphorylation] GO:0007165[signal transduction] GO:0007250[activation of NF-kappaB-inducing kinase activity] GO:0010008[endosome membrane] GO:0010468[regulation of gene expression] GO:0010556[regulation of macromolecule biosynthetic process] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0019221[cytokine-mediated signaling pathway] GO:0019901[protein kinase binding] GO:0031326[regulation of cellular biosynthetic process] GO:0031663[lipopolysaccharide-mediated signaling pathway] GO:0032088[negative regulation of NF-kappaB transcription factor activity] GO:0032481[positive regulation of type I interferon production] GO:0032496[response to lipopolysaccharide] GO:0032991[protein-containing complex] GO:0034134[toll-like receptor 2 signaling pathway] GO:0034142[toll-like receptor 4 signaling pathway] GO:0034162[toll-like receptor 9 signaling pathway] GO:0035556[intracellular signal transduction] GO:0042802[identical protein binding] GO:0042803[protein homodimerization activity] GO:0043123[positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043406[positive regulation of MAP kinase activity] GO:0044093[positive regulation of molecular function] GO:0045087[innate immune response] GO:0046777[protein autophosphorylation] GO:0046982[protein heterodimerization activity] GO:0048583[regulation of response to stimulus] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060337[type I interferon signaling pathway] GO:0070498[interleukin-1-mediated signaling pathway] GO:0070555[response to interleukin-1] GO:0071222[cellular response to lipopolysaccharide] GO:0071345[cellular response to cytokine stimulus] GO:0106310[protein serine kinase activity] GO:1901224[positive regulation of NIK/NF-kappaB signaling] GO:1904996[positive regulation of leukocyte adhesion to vascular endothelial cell]
SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0005524[ATP binding] GO:0006468[protein phosphorylation] GO:0048583[regulation of response to stimulus] GO:0070498[interleukin-1-mediated signaling pathway] GO:0071310[cellular response to organic substance]
The Human Protein Atlas project is funded
