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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes FDA approved drug targets Metabolic proteins Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
p31.3
Chromosome location (bp)
65792514 - 66374579
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes 1. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hydrolase
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
cAMP, Metal-binding, Zinc
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Hydrolases Metabolic proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
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GO:0001780[neutrophil homeostasis] GO:0004114[3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004115[3',5'-cyclic-AMP phosphodiesterase activity] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005891[voltage-gated calcium channel complex] GO:0006198[cAMP catabolic process] GO:0007165[signal transduction] GO:0008081[phosphoric diester hydrolase activity] GO:0016020[membrane] GO:0016787[hydrolase activity] GO:0030018[Z disc] GO:0030552[cAMP binding] GO:0030593[neutrophil chemotaxis] GO:0032729[positive regulation of interferon-gamma production] GO:0032743[positive regulation of interleukin-2 production] GO:0044325[transmembrane transporter binding] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0050852[T cell receptor signaling pathway] GO:0050900[leukocyte migration] GO:0071222[cellular response to lipopolysaccharide] GO:0071466[cellular response to xenobiotic stimulus] GO:0071872[cellular response to epinephrine stimulus] GO:0086004[regulation of cardiac muscle cell contraction] GO:1901841[regulation of high voltage-gated calcium channel activity] GO:1901898[negative regulation of relaxation of cardiac muscle]
Enzymes ENZYME proteins Hydrolases Metabolic proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0000930[gamma-tubulin complex] GO:0001780[neutrophil homeostasis] GO:0004114[3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004115[3',5'-cyclic-AMP phosphodiesterase activity] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005813[centrosome] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005891[voltage-gated calcium channel complex] GO:0006198[cAMP catabolic process] GO:0007165[signal transduction] GO:0008021[synaptic vesicle] GO:0008081[phosphoric diester hydrolase activity] GO:0014069[postsynaptic density] GO:0016020[membrane] GO:0016787[hydrolase activity] GO:0030018[Z disc] GO:0030552[cAMP binding] GO:0030593[neutrophil chemotaxis] GO:0032729[positive regulation of interferon-gamma production] GO:0032743[positive regulation of interleukin-2 production] GO:0043015[gamma-tubulin binding] GO:0043197[dendritic spine] GO:0044325[transmembrane transporter binding] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0050852[T cell receptor signaling pathway] GO:0050900[leukocyte migration] GO:0060076[excitatory synapse] GO:0071222[cellular response to lipopolysaccharide] GO:0071466[cellular response to xenobiotic stimulus] GO:0071872[cellular response to epinephrine stimulus] GO:0071944[cell periphery] GO:0086004[regulation of cardiac muscle cell contraction] GO:0140199[negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process] GO:1901841[regulation of high voltage-gated calcium channel activity] GO:1901898[negative regulation of relaxation of cardiac muscle]
Enzymes ENZYME proteins Hydrolases Metabolic proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0001780[neutrophil homeostasis] GO:0004114[3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004115[3',5'-cyclic-AMP phosphodiesterase activity] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005891[voltage-gated calcium channel complex] GO:0006198[cAMP catabolic process] GO:0007165[signal transduction] GO:0008081[phosphoric diester hydrolase activity] GO:0016020[membrane] GO:0016787[hydrolase activity] GO:0030018[Z disc] GO:0030552[cAMP binding] GO:0030593[neutrophil chemotaxis] GO:0032729[positive regulation of interferon-gamma production] GO:0032743[positive regulation of interleukin-2 production] GO:0044325[transmembrane transporter binding] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0050852[T cell receptor signaling pathway] GO:0050900[leukocyte migration] GO:0071222[cellular response to lipopolysaccharide] GO:0071466[cellular response to xenobiotic stimulus] GO:0071872[cellular response to epinephrine stimulus] GO:0086004[regulation of cardiac muscle cell contraction] GO:1901841[regulation of high voltage-gated calcium channel activity] GO:1901898[negative regulation of relaxation of cardiac muscle]
Enzymes ENZYME proteins Hydrolases Metabolic proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014)
Show all
GO:0001780[neutrophil homeostasis] GO:0004114[3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004115[3',5'-cyclic-AMP phosphodiesterase activity] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005891[voltage-gated calcium channel complex] GO:0006198[cAMP catabolic process] GO:0007165[signal transduction] GO:0008081[phosphoric diester hydrolase activity] GO:0016020[membrane] GO:0016787[hydrolase activity] GO:0030018[Z disc] GO:0030552[cAMP binding] GO:0030593[neutrophil chemotaxis] GO:0032729[positive regulation of interferon-gamma production] GO:0032743[positive regulation of interleukin-2 production] GO:0044325[transmembrane transporter binding] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0050852[T cell receptor signaling pathway] GO:0050900[leukocyte migration] GO:0071222[cellular response to lipopolysaccharide] GO:0071466[cellular response to xenobiotic stimulus] GO:0071872[cellular response to epinephrine stimulus] GO:0086004[regulation of cardiac muscle cell contraction] GO:1901841[regulation of high voltage-gated calcium channel activity] GO:1901898[negative regulation of relaxation of cardiac muscle]
Enzymes ENZYME proteins Hydrolases Metabolic proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level
Show all
GO:0001780[neutrophil homeostasis] GO:0004114[3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004115[3',5'-cyclic-AMP phosphodiesterase activity] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005891[voltage-gated calcium channel complex] GO:0006198[cAMP catabolic process] GO:0007165[signal transduction] GO:0008081[phosphoric diester hydrolase activity] GO:0016020[membrane] GO:0016787[hydrolase activity] GO:0030018[Z disc] GO:0030552[cAMP binding] GO:0030593[neutrophil chemotaxis] GO:0032729[positive regulation of interferon-gamma production] GO:0032743[positive regulation of interleukin-2 production] GO:0044325[transmembrane transporter binding] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0050852[T cell receptor signaling pathway] GO:0050900[leukocyte migration] GO:0071222[cellular response to lipopolysaccharide] GO:0071466[cellular response to xenobiotic stimulus] GO:0071872[cellular response to epinephrine stimulus] GO:0086004[regulation of cardiac muscle cell contraction] GO:1901841[regulation of high voltage-gated calcium channel activity] GO:1901898[negative regulation of relaxation of cardiac muscle]
The Human Protein Atlas project is funded
