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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
X
Cytoband
q13.1
Chromosome location (bp)
71118543 - 71144103
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Activator, Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Transcription, Transcription regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
A0A0A0MR79 [Direct mapping] Mediator of RNA polymerase II transcription subunit 12
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SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Human disease related genes Congenital malformations Other congenital malformations Reproductive system diseases Reproductive system diseases Protein evidence (Ezkurdia et al 2014)
Q93074 [Direct mapping] Mediator of RNA polymerase II transcription subunit 12
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SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Disease related genes Human disease related genes Congenital malformations Other congenital malformations Reproductive system diseases Reproductive system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000151[ubiquitin ligase complex] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0001756[somitogenesis] GO:0001843[neural tube closure] GO:0003682[chromatin binding] GO:0003712[transcription coregulator activity] GO:0003713[transcription coactivator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006351[DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0007492[endoderm development] GO:0007507[heart development] GO:0008013[beta-catenin binding] GO:0008022[protein C-terminus binding] GO:0014003[oligodendrocyte development] GO:0014044[Schwann cell development] GO:0016020[membrane] GO:0016567[protein ubiquitination] GO:0016592[mediator complex] GO:0019904[protein domain specific binding] GO:0021510[spinal cord development] GO:0021915[neural tube development] GO:0030374[nuclear receptor coactivator activity] GO:0035019[somatic stem cell population maintenance] GO:0036342[post-anal tail morphogenesis] GO:0042809[nuclear vitamin D receptor binding] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046966[nuclear thyroid hormone receptor binding] GO:0048568[embryonic organ development] GO:0048702[embryonic neurocranium morphogenesis] GO:0060071[Wnt signaling pathway, planar cell polarity pathway] GO:0060261[positive regulation of transcription initiation by RNA polymerase II] GO:0061630[ubiquitin protein ligase activity] GO:0090245[axis elongation involved in somitogenesis] GO:1990403[embryonic brain development]
Q93074 [Direct mapping] Mediator of RNA polymerase II transcription subunit 12
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SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Disease related genes Human disease related genes Congenital malformations Other congenital malformations Reproductive system diseases Reproductive system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0003712[transcription coregulator activity] GO:0003713[transcription coactivator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006351[DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008013[beta-catenin binding] GO:0008022[protein C-terminus binding] GO:0016020[membrane] GO:0016592[mediator complex] GO:0019904[protein domain specific binding] GO:0030374[nuclear receptor coactivator activity] GO:0042809[nuclear vitamin D receptor binding] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046966[nuclear thyroid hormone receptor binding] GO:0060261[positive regulation of transcription initiation by RNA polymerase II]
H7C274 [Direct mapping] Mediator of RNA polymerase II transcription subunit 12
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Human disease related genes Congenital malformations Other congenital malformations Reproductive system diseases Reproductive system diseases Protein evidence (Ezkurdia et al 2014)
A0A8I5QJW8 [Direct mapping] Mediator of RNA polymerase II transcription subunit 12
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SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Human disease related genes Congenital malformations Other congenital malformations Reproductive system diseases Reproductive system diseases Protein evidence (Ezkurdia et al 2014)
A0A8I5KVC2 [Direct mapping] Mediator of RNA polymerase II transcription subunit 12
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Human disease related genes Congenital malformations Other congenital malformations Reproductive system diseases Reproductive system diseases Protein evidence (Ezkurdia et al 2014)
A0A8I5KUR0 [Direct mapping] Mediator of RNA polymerase II transcription subunit 12
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SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Human disease related genes Congenital malformations Other congenital malformations Reproductive system diseases Reproductive system diseases Protein evidence (Ezkurdia et al 2014)
A0A8I5KW86 [Direct mapping] Mediator of RNA polymerase II transcription subunit 12
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SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Human disease related genes Congenital malformations Other congenital malformations Reproductive system diseases Reproductive system diseases Protein evidence (Ezkurdia et al 2014)
A0A8I5KRJ8 [Direct mapping] Mediator of RNA polymerase II transcription subunit 12
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MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Human disease related genes Congenital malformations Other congenital malformations Reproductive system diseases Reproductive system diseases Protein evidence (Ezkurdia et al 2014)
A0A8I5KXK9 [Direct mapping] Mediator of RNA polymerase II transcription subunit 12
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MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Human disease related genes Congenital malformations Other congenital malformations Reproductive system diseases Reproductive system diseases Protein evidence (Ezkurdia et al 2014)
Q93074 [Direct mapping] Mediator of RNA polymerase II transcription subunit 12
Show all
SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Disease related genes Human disease related genes Congenital malformations Other congenital malformations Reproductive system diseases Reproductive system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0003712[transcription coregulator activity] GO:0003713[transcription coactivator activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006351[DNA-templated transcription] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008013[beta-catenin binding] GO:0008022[protein C-terminus binding] GO:0016020[membrane] GO:0016592[mediator complex] GO:0019904[protein domain specific binding] GO:0030374[nuclear receptor coactivator activity] GO:0042809[nuclear vitamin D receptor binding] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0046966[nuclear thyroid hormone receptor binding] GO:0060261[positive regulation of transcription initiation by RNA polymerase II]
A0A8I5KQY2 [Direct mapping] Mediator of RNA polymerase II transcription subunit 12
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MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Human disease related genes Congenital malformations Other congenital malformations Reproductive system diseases Reproductive system diseases Protein evidence (Ezkurdia et al 2014)
A0A8I5KSA4 [Direct mapping] Mediator of RNA polymerase II transcription subunit 12
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MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Splicing Mutations COSMIC Somatic Mutations COSMIC Other Mutations COSMIC Missense Mutations Human disease related genes Congenital malformations Other congenital malformations Reproductive system diseases Reproductive system diseases Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
