We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes Human disease related genes Potential drug targets Transporters
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
15
Cytoband
q26.1
Chromosome location (bp)
90229975 - 90234047
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Calcium-binding protein that plays a role in the regulation of numerous cellular processes, such as cell differentiation, cell division, cell proliferation, cell migration, thrombosis, angiogenesis, cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte, a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity, and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner, the effect being negatively regulated by PAK1. Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Involved in sphingosine kinase SPHK1 translocation to the plasma membrane in a N-myristoylation-dependent manner preventing TNF-alpha-induced apoptosis. Regulates serine/threonine-protein kinase PLK3 activity for proper completion of cell division progression. Plays a role in microtubule (MT) dynamics during neuronal development; disrupts the MT depolymerization activity of STMN2 attenuating NGF-induced neurite outgrowth and the MT reorganization at the edge of lamellipodia. Promotes cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Stimulates calcineurin PPP3R1 activity by mediating its anchoring to the sarcolemma. In ischemia-induced (pathological or adaptive) angiogenesis, stimulates endothelial cell proliferation, migration and microvessel formation by activating the PAK1 and ERK1/ERK2 signaling pathway. Promotes also cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells, and/or differentiation of supporting Sertoli cells....show less
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium, Magnesium, Metal-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the EF-hand domain-containing calcium-binding superfamily. The encoded protein interacts with many other proteins, including the platelet integrin alpha-IIb-beta-3, DNA-dependent protein kinase, presenilin-2, focal adhesion kinase, p21 activated kinase, and protein kinase D. The encoded protein may be involved in cell survival and proliferation, and is associated with several disease states including cancer and Alzheimer's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q99828 [Direct mapping] Calcium and integrin-binding protein 1
Show all
A0A140VK09 [Target identity:100%; Query identity:100%] Testicular secretory protein Li 9
Show all
Transporters Accessory Factors Involved in Transport Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Human disease related genes Skin diseases Skin and soft tissue diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287[magnesium ion binding] GO:0001525[angiogenesis] GO:0001933[negative regulation of protein phosphorylation] GO:0001934[positive regulation of protein phosphorylation] GO:0001954[positive regulation of cell-matrix adhesion] GO:0002931[response to ischemia] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005794[Golgi apparatus] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0006302[double-strand break repair] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0007026[negative regulation of microtubule depolymerization] GO:0007049[cell cycle] GO:0007113[endomitotic cell cycle] GO:0007155[cell adhesion] GO:0007283[spermatogenesis] GO:0007286[spermatid development] GO:0008284[positive regulation of cell population proliferation] GO:0008285[negative regulation of cell population proliferation] GO:0008427[calcium-dependent protein kinase inhibitor activity] GO:0010977[negative regulation of neuron projection development] GO:0016020[membrane] GO:0016324[apical plasma membrane] GO:0030027[lamellipodium] GO:0030154[cell differentiation] GO:0030220[platelet formation] GO:0030291[protein serine/threonine kinase inhibitor activity] GO:0030307[positive regulation of cell growth] GO:0030335[positive regulation of cell migration] GO:0030424[axon] GO:0030426[growth cone] GO:0031122[cytoplasmic microtubule organization] GO:0031267[small GTPase binding] GO:0031982[vesicle] GO:0032433[filopodium tip] GO:0032587[ruffle membrane] GO:0033630[positive regulation of cell adhesion mediated by integrin] GO:0038163[thrombopoietin-mediated signaling pathway] GO:0042127[regulation of cell population proliferation] GO:0042383[sarcolemma] GO:0042995[cell projection] GO:0043005[neuron projection] GO:0043025[neuronal cell body] GO:0043066[negative regulation of apoptotic process] GO:0043085[positive regulation of catalytic activity] GO:0043204[perikaryon] GO:0043495[protein-membrane adaptor activity] GO:0044325[transmembrane transporter binding] GO:0045653[negative regulation of megakaryocyte differentiation] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051301[cell division] GO:0051302[regulation of cell division] GO:0051898[negative regulation of protein kinase B signaling] GO:0070062[extracellular exosome] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0070886[positive regulation of calcineurin-NFAT signaling cascade] GO:0071356[cellular response to tumor necrosis factor] GO:0071363[cellular response to growth factor stimulus] GO:0071902[positive regulation of protein serine/threonine kinase activity] GO:0071944[cell periphery] GO:0090050[positive regulation of cell migration involved in sprouting angiogenesis] GO:0090314[positive regulation of protein targeting to membrane] GO:0097191[extrinsic apoptotic signaling pathway] GO:1900026[positive regulation of substrate adhesion-dependent cell spreading] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1990090[cellular response to nerve growth factor stimulus] GO:2000256[positive regulation of male germ cell proliferation]
Q99828 [Direct mapping] Calcium and integrin-binding protein 1
Show all
Transporters Accessory Factors Involved in Transport SCAMPI predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Potential drug targets Human disease related genes Skin diseases Skin and soft tissue diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287[magnesium ion binding] GO:0001525[angiogenesis] GO:0001933[negative regulation of protein phosphorylation] GO:0001934[positive regulation of protein phosphorylation] GO:0001954[positive regulation of cell-matrix adhesion] GO:0002931[response to ischemia] GO:0005509[calcium ion binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005783[endoplasmic reticulum] GO:0005794[Golgi apparatus] GO:0005813[centrosome] GO:0005815[microtubule organizing center] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0006302[double-strand break repair] GO:0006915[apoptotic process] GO:0006974[cellular response to DNA damage stimulus] GO:0007026[negative regulation of microtubule depolymerization] GO:0007049[cell cycle] GO:0007113[endomitotic cell cycle] GO:0007155[cell adhesion] GO:0007283[spermatogenesis] GO:0007286[spermatid development] GO:0008284[positive regulation of cell population proliferation] GO:0008285[negative regulation of cell population proliferation] GO:0008427[calcium-dependent protein kinase inhibitor activity] GO:0010977[negative regulation of neuron projection development] GO:0016020[membrane] GO:0016324[apical plasma membrane] GO:0030027[lamellipodium] GO:0030154[cell differentiation] GO:0030220[platelet formation] GO:0030291[protein serine/threonine kinase inhibitor activity] GO:0030307[positive regulation of cell growth] GO:0030335[positive regulation of cell migration] GO:0030424[axon] GO:0030426[growth cone] GO:0031122[cytoplasmic microtubule organization] GO:0031267[small GTPase binding] GO:0031982[vesicle] GO:0032433[filopodium tip] GO:0032587[ruffle membrane] GO:0033630[positive regulation of cell adhesion mediated by integrin] GO:0038163[thrombopoietin-mediated signaling pathway] GO:0042127[regulation of cell population proliferation] GO:0042383[sarcolemma] GO:0042995[cell projection] GO:0043005[neuron projection] GO:0043025[neuronal cell body] GO:0043066[negative regulation of apoptotic process] GO:0043085[positive regulation of catalytic activity] GO:0043204[perikaryon] GO:0043495[protein-membrane adaptor activity] GO:0045653[negative regulation of megakaryocyte differentiation] GO:0046872[metal ion binding] GO:0048471[perinuclear region of cytoplasm] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051301[cell division] GO:0051302[regulation of cell division] GO:0051898[negative regulation of protein kinase B signaling] GO:0070062[extracellular exosome] GO:0070374[positive regulation of ERK1 and ERK2 cascade] GO:0070886[positive regulation of calcineurin-NFAT signaling cascade] GO:0071356[cellular response to tumor necrosis factor] GO:0071363[cellular response to growth factor stimulus] GO:0071902[positive regulation of protein serine/threonine kinase activity] GO:0071944[cell periphery] GO:0090050[positive regulation of cell migration involved in sprouting angiogenesis] GO:0090314[positive regulation of protein targeting to membrane] GO:0097191[extrinsic apoptotic signaling pathway] GO:1900026[positive regulation of substrate adhesion-dependent cell spreading] GO:1903078[positive regulation of protein localization to plasma membrane] GO:1990090[cellular response to nerve growth factor stimulus] GO:2000256[positive regulation of male germ cell proliferation]
A0A3B3ISY8 [Direct mapping] Calcium and integrin-binding protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Skin diseases Skin and soft tissue diseases Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
