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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes CD markers Disease related genes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
q22
Chromosome location (bp)
155185824 - 155192916
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack....show less
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of the urinary system Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0002039[p53 binding] GO:0003712[transcription coregulator activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005796[Golgi lumen] GO:0005886[plasma membrane] GO:0006351[DNA-templated transcription] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978[DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0010944[negative regulation of transcription by competitive promoter binding] GO:0016020[membrane] GO:0016324[apical plasma membrane] GO:0031982[vesicle] GO:0033629[negative regulation of cell adhesion mediated by integrin] GO:0036003[positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618[regulation of transcription from RNA polymerase II promoter in response to stress] GO:0051179[localization] GO:0070062[extracellular exosome] GO:0090240[positive regulation of histone H4 acetylation] GO:1902166[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of the urinary system Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0002039[p53 binding] GO:0003712[transcription coregulator activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005796[Golgi lumen] GO:0005886[plasma membrane] GO:0006351[DNA-templated transcription] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978[DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0010944[negative regulation of transcription by competitive promoter binding] GO:0016020[membrane] GO:0016324[apical plasma membrane] GO:0031982[vesicle] GO:0033629[negative regulation of cell adhesion mediated by integrin] GO:0036003[positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618[regulation of transcription from RNA polymerase II promoter in response to stress] GO:0051179[localization] GO:0070062[extracellular exosome] GO:0090240[positive regulation of histone H4 acetylation] GO:1902166[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of the urinary system Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0002039[p53 binding] GO:0003712[transcription coregulator activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005796[Golgi lumen] GO:0005886[plasma membrane] GO:0006351[DNA-templated transcription] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978[DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0010944[negative regulation of transcription by competitive promoter binding] GO:0016020[membrane] GO:0016324[apical plasma membrane] GO:0031982[vesicle] GO:0033629[negative regulation of cell adhesion mediated by integrin] GO:0036003[positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618[regulation of transcription from RNA polymerase II promoter in response to stress] GO:0051179[localization] GO:0070062[extracellular exosome] GO:0090240[positive regulation of histone H4 acetylation] GO:1902166[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
CD markers THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of the urinary system Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0002039[p53 binding] GO:0003712[transcription coregulator activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005796[Golgi lumen] GO:0005886[plasma membrane] GO:0006351[DNA-templated transcription] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978[DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0010944[negative regulation of transcription by competitive promoter binding] GO:0016020[membrane] GO:0016324[apical plasma membrane] GO:0031982[vesicle] GO:0033629[negative regulation of cell adhesion mediated by integrin] GO:0036003[positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618[regulation of transcription from RNA polymerase II promoter in response to stress] GO:0051179[localization] GO:0070062[extracellular exosome] GO:0090240[positive regulation of histone H4 acetylation] GO:1902166[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of the urinary system Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0002039[p53 binding] GO:0003712[transcription coregulator activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005796[Golgi lumen] GO:0005886[plasma membrane] GO:0006351[DNA-templated transcription] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978[DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0010944[negative regulation of transcription by competitive promoter binding] GO:0016020[membrane] GO:0016324[apical plasma membrane] GO:0031982[vesicle] GO:0033629[negative regulation of cell adhesion mediated by integrin] GO:0036003[positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618[regulation of transcription from RNA polymerase II promoter in response to stress] GO:0051179[localization] GO:0070062[extracellular exosome] GO:0090240[positive regulation of histone H4 acetylation] GO:1902166[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of the urinary system Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0002039[p53 binding] GO:0003712[transcription coregulator activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005796[Golgi lumen] GO:0005886[plasma membrane] GO:0006351[DNA-templated transcription] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978[DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0010944[negative regulation of transcription by competitive promoter binding] GO:0016020[membrane] GO:0016324[apical plasma membrane] GO:0031982[vesicle] GO:0033629[negative regulation of cell adhesion mediated by integrin] GO:0036003[positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618[regulation of transcription from RNA polymerase II promoter in response to stress] GO:0051179[localization] GO:0070062[extracellular exosome] GO:0090240[positive regulation of histone H4 acetylation] GO:1902166[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
CD markers THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of the urinary system Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0002039[p53 binding] GO:0003712[transcription coregulator activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005796[Golgi lumen] GO:0005886[plasma membrane] GO:0006351[DNA-templated transcription] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978[DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0010944[negative regulation of transcription by competitive promoter binding] GO:0016020[membrane] GO:0016324[apical plasma membrane] GO:0031982[vesicle] GO:0033629[negative regulation of cell adhesion mediated by integrin] GO:0036003[positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618[regulation of transcription from RNA polymerase II promoter in response to stress] GO:0051179[localization] GO:0070062[extracellular exosome] GO:0090240[positive regulation of histone H4 acetylation] GO:1902166[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
A0A384NPK6 [Target identity:100%; Query identity:100%] Epididymis secretory sperm binding protein
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CD markers MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of the urinary system Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0002039[p53 binding] GO:0003712[transcription coregulator activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005796[Golgi lumen] GO:0005886[plasma membrane] GO:0006351[DNA-templated transcription] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978[DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0010944[negative regulation of transcription by competitive promoter binding] GO:0016020[membrane] GO:0016324[apical plasma membrane] GO:0031982[vesicle] GO:0033629[negative regulation of cell adhesion mediated by integrin] GO:0036003[positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618[regulation of transcription from RNA polymerase II promoter in response to stress] GO:0051179[localization] GO:0070062[extracellular exosome] GO:0090240[positive regulation of histone H4 acetylation] GO:1902166[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Human disease related genes Congenital malformations Congenital malformations of the urinary system Urinary system diseases Kidney diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
Show all
GO:0000785[chromatin] GO:0000978[RNA polymerase II cis-regulatory region sequence-specific DNA binding] GO:0002039[p53 binding] GO:0003712[transcription coregulator activity] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005796[Golgi lumen] GO:0005886[plasma membrane] GO:0006351[DNA-templated transcription] GO:0006977[DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0006978[DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator] GO:0010944[negative regulation of transcription by competitive promoter binding] GO:0016020[membrane] GO:0016324[apical plasma membrane] GO:0031982[vesicle] GO:0033629[negative regulation of cell adhesion mediated by integrin] GO:0036003[positive regulation of transcription from RNA polymerase II promoter in response to stress] GO:0043618[regulation of transcription from RNA polymerase II promoter in response to stress] GO:0051179[localization] GO:0070062[extracellular exosome] GO:0090240[positive regulation of histone H4 acetylation] GO:1902166[negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator]
SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Human disease related genes Congenital malformations Congenital malformations of the urinary system Urinary system diseases Kidney diseases Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
