We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Metabolic proteins Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
22
Cytoband
q11.21
Chromosome location (bp)
21549447 - 21624034
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Ubiquitin-conjugating enzyme E2 that specifically acts with HECT-type and RBR family E3 ubiquitin-protein ligases. Does not function with most RING-containing E3 ubiquitin-protein ligases because it lacks intrinsic E3-independent reactivity with lysine: in contrast, it has activity with the RBR family E3 enzymes, such as PRKN, RNF31 and ARIH1, that function like RING-HECT hybrids. Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Involved in the selective degradation of short-lived and abnormal proteins. Down-regulated during the S-phase it is involved in progression through the cell cycle. Regulates nuclear hormone receptors transcriptional activity. May play a role in myelopoiesis....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Transferase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151[ubiquitin ligase complex] GO:0000166[nucleotide binding] GO:0000209[protein polyubiquitination] GO:0003713[transcription coactivator activity] GO:0003723[RNA binding] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0008283[cell population proliferation] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019787[ubiquitin-like protein transferase activity] GO:0019899[enzyme binding] GO:0031398[positive regulation of protein ubiquitination] GO:0031625[ubiquitin protein ligase binding] GO:0032446[protein modification by small protein conjugation] GO:0036211[protein modification process] GO:0044770[cell cycle phase transition] GO:0045893[positive regulation of DNA-templated transcription] GO:0051443[positive regulation of ubiquitin-protein transferase activity] GO:0061631[ubiquitin conjugating enzyme activity] GO:0070979[protein K11-linked ubiquitination] GO:0071383[cellular response to steroid hormone stimulus] GO:0071385[cellular response to glucocorticoid stimulus] GO:0097027[ubiquitin-protein transferase activator activity] GO:1903955[positive regulation of protein targeting to mitochondrion]
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151[ubiquitin ligase complex] GO:0000166[nucleotide binding] GO:0000209[protein polyubiquitination] GO:0003713[transcription coactivator activity] GO:0003723[RNA binding] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0008283[cell population proliferation] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019787[ubiquitin-like protein transferase activity] GO:0019899[enzyme binding] GO:0031398[positive regulation of protein ubiquitination] GO:0031625[ubiquitin protein ligase binding] GO:0032446[protein modification by small protein conjugation] GO:0036211[protein modification process] GO:0044770[cell cycle phase transition] GO:0045893[positive regulation of DNA-templated transcription] GO:0051443[positive regulation of ubiquitin-protein transferase activity] GO:0061631[ubiquitin conjugating enzyme activity] GO:0070979[protein K11-linked ubiquitination] GO:0071383[cellular response to steroid hormone stimulus] GO:0071385[cellular response to glucocorticoid stimulus] GO:0097027[ubiquitin-protein transferase activator activity] GO:1903955[positive regulation of protein targeting to mitochondrion]
Enzymes ENZYME proteins Transferases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000151[ubiquitin ligase complex] GO:0000166[nucleotide binding] GO:0000209[protein polyubiquitination] GO:0003713[transcription coactivator activity] GO:0003723[RNA binding] GO:0004842[ubiquitin-protein transferase activity] GO:0005515[protein binding] GO:0005524[ATP binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006355[regulation of DNA-templated transcription] GO:0006511[ubiquitin-dependent protein catabolic process] GO:0008283[cell population proliferation] GO:0016567[protein ubiquitination] GO:0016740[transferase activity] GO:0019787[ubiquitin-like protein transferase activity] GO:0019899[enzyme binding] GO:0031398[positive regulation of protein ubiquitination] GO:0031625[ubiquitin protein ligase binding] GO:0032446[protein modification by small protein conjugation] GO:0036211[protein modification process] GO:0044770[cell cycle phase transition] GO:0045893[positive regulation of DNA-templated transcription] GO:0051443[positive regulation of ubiquitin-protein transferase activity] GO:0061631[ubiquitin conjugating enzyme activity] GO:0070979[protein K11-linked ubiquitination] GO:0071383[cellular response to steroid hormone stimulus] GO:0071385[cellular response to glucocorticoid stimulus] GO:0097027[ubiquitin-protein transferase activator activity] GO:1903955[positive regulation of protein targeting to mitochondrion]
The Human Protein Atlas project is funded
