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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
15
Cytoband
q25.1
Chromosome location (bp)
78810487 - 78898139
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. As part of the SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 1,2,3. SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription 4. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Chromatin regulator
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
DNA damage, DNA recombination, DNA repair, Growth regulation, Transcription, Transcription regulation
Gene summary (Entrez)i
Useful information about the gene from Entrez
Enables protein N-terminus binding activity. Involved in double-strand break repair via homologous recombination and histone modification. Located in nuclear speck. Part of NuA4 histone acetyltransferase complex and Sin3 complex. [provided by Alliance of Genome Resources, Apr 2022]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q9UBU8 [Direct mapping] Mortality factor 4-like protein 1
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000123[histone acetyltransferase complex] GO:0000724[double-strand break repair via homologous recombination] GO:0000786[nucleosome] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006281[DNA repair] GO:0006310[DNA recombination] GO:0006325[chromatin organization] GO:0006355[regulation of DNA-templated transcription] GO:0006974[cellular response to DNA damage stimulus] GO:0010468[regulation of gene expression] GO:0016573[histone acetylation] GO:0016575[histone deacetylation] GO:0016580[Sin3 complex] GO:0016607[nuclear speck] GO:0035267[NuA4 histone acetyltransferase complex] GO:0042981[regulation of apoptotic process] GO:0043967[histone H4 acetylation] GO:0043968[histone H2A acetylation] GO:0045893[positive regulation of DNA-templated transcription] GO:0047485[protein N-terminus binding] GO:0051171[regulation of nitrogen compound metabolic process] GO:0051726[regulation of cell cycle] GO:0080090[regulation of primary metabolic process] GO:1905168[positive regulation of double-strand break repair via homologous recombination] GO:2000779[regulation of double-strand break repair]
Q9UBU8 [Direct mapping] Mortality factor 4-like protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000123[histone acetyltransferase complex] GO:0000724[double-strand break repair via homologous recombination] GO:0000786[nucleosome] GO:0003682[chromatin binding] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006281[DNA repair] GO:0006310[DNA recombination] GO:0006325[chromatin organization] GO:0006355[regulation of DNA-templated transcription] GO:0006974[cellular response to DNA damage stimulus] GO:0008283[cell population proliferation] GO:0010468[regulation of gene expression] GO:0016573[histone acetylation] GO:0016575[histone deacetylation] GO:0016580[Sin3 complex] GO:0016607[nuclear speck] GO:0035267[NuA4 histone acetyltransferase complex] GO:0042981[regulation of apoptotic process] GO:0043967[histone H4 acetylation] GO:0043968[histone H2A acetylation] GO:0045893[positive regulation of DNA-templated transcription] GO:0047485[protein N-terminus binding] GO:0048144[fibroblast proliferation] GO:0051171[regulation of nitrogen compound metabolic process] GO:0051726[regulation of cell cycle] GO:0080090[regulation of primary metabolic process] GO:1905168[positive regulation of double-strand break repair via homologous recombination] GO:2000779[regulation of double-strand break repair]
Q9UBU8 [Direct mapping] Mortality factor 4-like protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000123[histone acetyltransferase complex] GO:0000724[double-strand break repair via homologous recombination] GO:0000786[nucleosome] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006281[DNA repair] GO:0006310[DNA recombination] GO:0006325[chromatin organization] GO:0006355[regulation of DNA-templated transcription] GO:0006974[cellular response to DNA damage stimulus] GO:0010468[regulation of gene expression] GO:0016573[histone acetylation] GO:0016575[histone deacetylation] GO:0016580[Sin3 complex] GO:0016607[nuclear speck] GO:0035267[NuA4 histone acetyltransferase complex] GO:0042981[regulation of apoptotic process] GO:0043967[histone H4 acetylation] GO:0043968[histone H2A acetylation] GO:0045893[positive regulation of DNA-templated transcription] GO:0047485[protein N-terminus binding] GO:0051171[regulation of nitrogen compound metabolic process] GO:0051726[regulation of cell cycle] GO:0080090[regulation of primary metabolic process] GO:1905168[positive regulation of double-strand break repair via homologous recombination] GO:2000779[regulation of double-strand break repair]
Q9UBU8 [Direct mapping] Mortality factor 4-like protein 1
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000123[histone acetyltransferase complex] GO:0000724[double-strand break repair via homologous recombination] GO:0000786[nucleosome] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0006281[DNA repair] GO:0006310[DNA recombination] GO:0006325[chromatin organization] GO:0006355[regulation of DNA-templated transcription] GO:0006974[cellular response to DNA damage stimulus] GO:0010468[regulation of gene expression] GO:0016573[histone acetylation] GO:0016575[histone deacetylation] GO:0016580[Sin3 complex] GO:0016607[nuclear speck] GO:0035267[NuA4 histone acetyltransferase complex] GO:0042981[regulation of apoptotic process] GO:0043967[histone H4 acetylation] GO:0043968[histone H2A acetylation] GO:0045893[positive regulation of DNA-templated transcription] GO:0047485[protein N-terminus binding] GO:0051171[regulation of nitrogen compound metabolic process] GO:0051726[regulation of cell cycle] GO:0080090[regulation of primary metabolic process] GO:1905168[positive regulation of double-strand break repair via homologous recombination] GO:2000779[regulation of double-strand break repair]
The Human Protein Atlas project is funded
