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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
CD markers
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
19
Cytoband
q13.42
Chromosome location (bp)
54643889 - 54670359
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance 1. Receptor for FN1 2. Receptor for apolipoprotein APOE 3. Receptor for ALCAM/CD166 4. Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions 5. Inhibits FCGR1A/CD64-mediated monocyte activation by inducing phosphatase-mediated down-regulation of the phosphorylation of multiple proteins including LCK, SYK, LAT and ERK, leading to a reduction in TNF production 6. This inhibition of monocyte activation occurs at least in part via binding to FN1 7. Inhibits T cell proliferation, inducing anergy, suppressing the differentiation of IFNG-producing CD8+ cytoxic T cells and enhancing the generation of CD8+ T suppressor cells 8,9,10. Induces up-regulation of CD86 on dendritic cells 11. Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation 12....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Receptor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Adaptive immunity, Immunity
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q8NHJ6 [Direct mapping] Leukocyte immunoglobulin-like receptor subfamily B member 4
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CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014) DeepTMHMM predicted membrane proteins
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GO:0001968[fibronectin binding] GO:0002250[adaptive immune response] GO:0002376[immune system process] GO:0002507[tolerance induction] GO:0002669[positive regulation of T cell anergy] GO:0002725[negative regulation of T cell cytokine production] GO:0002774[Fc receptor mediated inhibitory signaling pathway] GO:0005515[protein binding] GO:0005886[plasma membrane] GO:0009898[cytoplasmic side of plasma membrane] GO:0009986[cell surface] GO:0016020[membrane] GO:0019903[protein phosphatase binding] GO:0030293[transmembrane receptor protein tyrosine kinase inhibitor activity] GO:0030547[signaling receptor inhibitor activity] GO:0031623[receptor internalization] GO:0032682[negative regulation of chemokine production] GO:0032689[negative regulation of interferon-gamma production] GO:0032691[negative regulation of interleukin-1 beta production] GO:0032693[negative regulation of interleukin-10 production] GO:0032703[negative regulation of interleukin-2 production] GO:0032714[negative regulation of interleukin-5 production] GO:0032715[negative regulation of interleukin-6 production] GO:0032720[negative regulation of tumor necrosis factor production] GO:0034185[apolipoprotein binding] GO:0042130[negative regulation of T cell proliferation] GO:0043124[negative regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043378[positive regulation of CD8-positive, alpha-beta T cell differentiation] GO:0043409[negative regulation of MAPK cascade] GO:0045584[negative regulation of cytotoxic T cell differentiation] GO:0045591[positive regulation of regulatory T cell differentiation] GO:0045671[negative regulation of osteoclast differentiation] GO:0046007[negative regulation of activated T cell proliferation] GO:0050860[negative regulation of T cell receptor signaling pathway] GO:0061099[negative regulation of protein tyrosine kinase activity] GO:0070062[extracellular exosome] GO:0071659[negative regulation of IP-10 production] GO:0140105[interleukin-10-mediated signaling pathway] GO:0150102[negative regulation of monocyte activation] GO:1900016[negative regulation of cytokine production involved in inflammatory response] GO:1900181[negative regulation of protein localization to nucleus] GO:1902894[negative regulation of miRNA transcription] GO:2000272[negative regulation of signaling receptor activity] GO:2000524[negative regulation of T cell costimulation]
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