GENERAL INFORMATIONi
Gene namei MAPT
Synonyms DDPAC, FLJ31424, FTDP-17, MAPTL, MGC138549, MSTD, MTBT1, MTBT2, PPND, PPP1R103, tau, tau-40
Gene descriptioni Microtubule associated protein tau
Protein classi Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
Human disease related genes
Plasma proteins
Predicted locationi Secreted, Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 17
Cytoband q21.31
Chromosome location (bp) 45894527 - 46028334
Number of transcriptsi 12
Ensembl ENSG00000186868 (version 109)
Entrez gene 4137
HGNC HGNC:6893
UniProt P10636 (UniProt - Evidence at protein level)
neXtProt NX_P10636
GeneCards MAPT
Antibodypedia MAPT antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity 1. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both 2, 3. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. show less
Gene summary (Entrez)i This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
MAPT-201
ENSP00000262410
ENST00000262410
A0A7I2PJZ2
[Direct mapping] Microtubule-associated protein
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0008017 [microtubule binding]
GO:0015631 [tubulin binding]
GO:0016020 [membrane]
GO:0030424 [axon]
GO:0042995 [cell projection]
Show all
 833 aa
86.9 kDa 		No 0
MAPT-202
ENSP00000334886
ENST00000334239
P10636
[Direct mapping] Microtubule-associated protein tau
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0001774 [microglial cell activation]
GO:0003677 [DNA binding]
GO:0003680 [minor groove of adenine-thymine-rich DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003723 [RNA binding]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0006475 [internal protein amino acid acetylation]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007267 [cell-cell signaling]
GO:0007613 [memory]
GO:0008017 [microtubule binding]
GO:0010288 [response to lead ion]
GO:0010506 [regulation of autophagy]
GO:0010629 [negative regulation of gene expression]
GO:0010917 [negative regulation of mitochondrial membrane potential]
GO:0015630 [microtubule cytoskeleton]
GO:0015631 [tubulin binding]
GO:0016020 [membrane]
GO:0016072 [rRNA metabolic process]
GO:0016607 [nuclear speck]
GO:0017124 [SH3 domain binding]
GO:0019896 [axonal transport of mitochondrion]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0021954 [central nervous system neuron development]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0030673 [axolemma]
GO:0030674 [protein-macromolecule adaptor activity]
GO:0031110 [regulation of microtubule polymerization or depolymerization]
GO:0031113 [regulation of microtubule polymerization]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031122 [cytoplasmic microtubule organization]
GO:0031175 [neuron projection development]
GO:0032930 [positive regulation of superoxide anion generation]
GO:0033044 [regulation of chromosome organization]
GO:0033673 [negative regulation of kinase activity]
GO:0034063 [stress granule assembly]
GO:0034185 [apolipoprotein binding]
GO:0034399 [nuclear periphery]
GO:0034452 [dynactin binding]
GO:0034605 [cellular response to heat]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035091 [phosphatidylinositol binding]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0036477 [somatodendritic compartment]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043197 [dendritic spine]
GO:0043565 [sequence-specific DNA binding]
GO:0044297 [cell body]
GO:0044304 [main axon]
GO:0045121 [membrane raft]
GO:0045298 [tubulin complex]
GO:0045773 [positive regulation of axon extension]
GO:0046785 [microtubule polymerization]
GO:0048143 [astrocyte activation]
GO:0048167 [regulation of synaptic plasticity]
GO:0048312 [intracellular distribution of mitochondria]
GO:0048699 [generation of neurons]
GO:0050808 [synapse organization]
GO:0050848 [regulation of calcium-mediated signaling]
GO:0051087 [chaperone binding]
GO:0051258 [protein polymerization]
GO:0051721 [protein phosphatase 2A binding]
GO:0051879 [Hsp90 protein binding]
GO:0061564 [axon development]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0071813 [lipoprotein particle binding]
GO:0072386 [plus-end-directed organelle transport along microtubule]
GO:0090140 [regulation of mitochondrial fission]
GO:0090258 [negative regulation of mitochondrial fission]
GO:0097386 [glial cell projection]
GO:0097418 [neurofibrillary tangle]
GO:0097435 [supramolecular fiber organization]
GO:0098930 [axonal transport]
GO:0099077 [histone-dependent DNA binding]
GO:0099609 [microtubule lateral binding]
GO:1900034 [regulation of cellular response to heat]
GO:1900452 [regulation of long-term synaptic depression]
GO:1901216 [positive regulation of neuron death]
GO:1902474 [positive regulation of protein localization to synapse]
GO:1902936 [phosphatidylinositol bisphosphate binding]
GO:1902988 [neurofibrillary tangle assembly]
GO:1903748 [negative regulation of establishment of protein localization to mitochondrion]
GO:1903829 [positive regulation of protein localization]
GO:1904115 [axon cytoplasm]
GO:1904428 [negative regulation of tubulin deacetylation]
GO:1905689 [positive regulation of diacylglycerol kinase activity]
GO:1990000 [amyloid fibril formation]
GO:1990090 [cellular response to nerve growth factor stimulus]
GO:1990416 [cellular response to brain-derived neurotrophic factor stimulus]
GO:2001020 [regulation of response to DNA damage stimulus]
Show all
 352 aa
36.8 kDa 		No 0
MAPT-203
ENSP00000340820
ENST00000344290
A0A7I2PLE3
[Direct mapping] Microtubule-associated protein
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0008017 [microtubule binding]
GO:0015631 [tubulin binding]
GO:0016020 [membrane]
GO:0030424 [axon]
GO:0042995 [cell projection]
Show all
 736 aa
76.8 kDa 		No 0
MAPT-204
ENSP00000303214
ENST00000351559
P10636
[Direct mapping] Microtubule-associated protein tau
Show all
A0A024RA17
[Target identity:100%; Query identity:100%] Microtubule-associated protein
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0001774 [microglial cell activation]
GO:0003677 [DNA binding]
GO:0003680 [minor groove of adenine-thymine-rich DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003723 [RNA binding]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0006475 [internal protein amino acid acetylation]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007267 [cell-cell signaling]
GO:0007416 [synapse assembly]
GO:0007611 [learning or memory]
GO:0007613 [memory]
GO:0008017 [microtubule binding]
GO:0010288 [response to lead ion]
GO:0010506 [regulation of autophagy]
GO:0010629 [negative regulation of gene expression]
GO:0010917 [negative regulation of mitochondrial membrane potential]
GO:0015630 [microtubule cytoskeleton]
GO:0015631 [tubulin binding]
GO:0016020 [membrane]
GO:0016072 [rRNA metabolic process]
GO:0016607 [nuclear speck]
GO:0017124 [SH3 domain binding]
GO:0019896 [axonal transport of mitochondrion]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0021954 [central nervous system neuron development]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0030673 [axolemma]
GO:0030674 [protein-macromolecule adaptor activity]
GO:0031110 [regulation of microtubule polymerization or depolymerization]
GO:0031113 [regulation of microtubule polymerization]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031122 [cytoplasmic microtubule organization]
GO:0031175 [neuron projection development]
GO:0032930 [positive regulation of superoxide anion generation]
GO:0033044 [regulation of chromosome organization]
GO:0033673 [negative regulation of kinase activity]
GO:0034063 [stress granule assembly]
GO:0034185 [apolipoprotein binding]
GO:0034399 [nuclear periphery]
GO:0034452 [dynactin binding]
GO:0034605 [cellular response to heat]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035091 [phosphatidylinositol binding]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0036477 [somatodendritic compartment]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043197 [dendritic spine]
GO:0043565 [sequence-specific DNA binding]
GO:0044297 [cell body]
GO:0044304 [main axon]
GO:0045121 [membrane raft]
GO:0045298 [tubulin complex]
GO:0045773 [positive regulation of axon extension]
GO:0046785 [microtubule polymerization]
GO:0048143 [astrocyte activation]
GO:0048167 [regulation of synaptic plasticity]
GO:0048312 [intracellular distribution of mitochondria]
GO:0048699 [generation of neurons]
GO:0050808 [synapse organization]
GO:0050848 [regulation of calcium-mediated signaling]
GO:0051087 [chaperone binding]
GO:0051258 [protein polymerization]
GO:0051260 [protein homooligomerization]
GO:0051721 [protein phosphatase 2A binding]
GO:0051879 [Hsp90 protein binding]
GO:0061564 [axon development]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0071813 [lipoprotein particle binding]
GO:0072386 [plus-end-directed organelle transport along microtubule]
GO:0090140 [regulation of mitochondrial fission]
GO:0090258 [negative regulation of mitochondrial fission]
GO:0097386 [glial cell projection]
GO:0097418 [neurofibrillary tangle]
GO:0097435 [supramolecular fiber organization]
GO:0098930 [axonal transport]
GO:0099077 [histone-dependent DNA binding]
GO:0099609 [microtubule lateral binding]
GO:1900034 [regulation of cellular response to heat]
GO:1900452 [regulation of long-term synaptic depression]
GO:1901216 [positive regulation of neuron death]
GO:1902474 [positive regulation of protein localization to synapse]
GO:1902936 [phosphatidylinositol bisphosphate binding]
GO:1902988 [neurofibrillary tangle assembly]
GO:1903748 [negative regulation of establishment of protein localization to mitochondrion]
GO:1903829 [positive regulation of protein localization]
GO:1904115 [axon cytoplasm]
GO:1904428 [negative regulation of tubulin deacetylation]
GO:1905689 [positive regulation of diacylglycerol kinase activity]
GO:1990000 [amyloid fibril formation]
GO:1990090 [cellular response to nerve growth factor stimulus]
GO:1990416 [cellular response to brain-derived neurotrophic factor stimulus]
GO:2001020 [regulation of response to DNA damage stimulus]
Show all
 441 aa
45.8 kDa 		No 0
MAPT-205
ENSP00000410838
ENST00000415613
P10636
[Direct mapping] Microtubule-associated protein tau
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0001774 [microglial cell activation]
GO:0003677 [DNA binding]
GO:0003680 [minor groove of adenine-thymine-rich DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003723 [RNA binding]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0006475 [internal protein amino acid acetylation]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007267 [cell-cell signaling]
GO:0007613 [memory]
GO:0008017 [microtubule binding]
GO:0010288 [response to lead ion]
GO:0010506 [regulation of autophagy]
GO:0010629 [negative regulation of gene expression]
GO:0010917 [negative regulation of mitochondrial membrane potential]
GO:0015630 [microtubule cytoskeleton]
GO:0015631 [tubulin binding]
GO:0016020 [membrane]
GO:0016072 [rRNA metabolic process]
GO:0016607 [nuclear speck]
GO:0017124 [SH3 domain binding]
GO:0019896 [axonal transport of mitochondrion]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0021954 [central nervous system neuron development]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0030673 [axolemma]
GO:0030674 [protein-macromolecule adaptor activity]
GO:0031110 [regulation of microtubule polymerization or depolymerization]
GO:0031113 [regulation of microtubule polymerization]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031122 [cytoplasmic microtubule organization]
GO:0031175 [neuron projection development]
GO:0032930 [positive regulation of superoxide anion generation]
GO:0033044 [regulation of chromosome organization]
GO:0033673 [negative regulation of kinase activity]
GO:0034063 [stress granule assembly]
GO:0034185 [apolipoprotein binding]
GO:0034399 [nuclear periphery]
GO:0034452 [dynactin binding]
GO:0034605 [cellular response to heat]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035091 [phosphatidylinositol binding]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0036477 [somatodendritic compartment]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043197 [dendritic spine]
GO:0043565 [sequence-specific DNA binding]
GO:0044297 [cell body]
GO:0044304 [main axon]
GO:0045121 [membrane raft]
GO:0045298 [tubulin complex]
GO:0045773 [positive regulation of axon extension]
GO:0046785 [microtubule polymerization]
GO:0048143 [astrocyte activation]
GO:0048167 [regulation of synaptic plasticity]
GO:0048312 [intracellular distribution of mitochondria]
GO:0048699 [generation of neurons]
GO:0050808 [synapse organization]
GO:0050848 [regulation of calcium-mediated signaling]
GO:0051087 [chaperone binding]
GO:0051258 [protein polymerization]
GO:0051721 [protein phosphatase 2A binding]
GO:0051879 [Hsp90 protein binding]
GO:0061564 [axon development]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0071813 [lipoprotein particle binding]
GO:0072386 [plus-end-directed organelle transport along microtubule]
GO:0090140 [regulation of mitochondrial fission]
GO:0090258 [negative regulation of mitochondrial fission]
GO:0097386 [glial cell projection]
GO:0097418 [neurofibrillary tangle]
GO:0097435 [supramolecular fiber organization]
GO:0098930 [axonal transport]
GO:0099077 [histone-dependent DNA binding]
GO:0099609 [microtubule lateral binding]
GO:1900034 [regulation of cellular response to heat]
GO:1900452 [regulation of long-term synaptic depression]
GO:1901216 [positive regulation of neuron death]
GO:1902474 [positive regulation of protein localization to synapse]
GO:1902936 [phosphatidylinositol bisphosphate binding]
GO:1902988 [neurofibrillary tangle assembly]
GO:1903748 [negative regulation of establishment of protein localization to mitochondrion]
GO:1903829 [positive regulation of protein localization]
GO:1904115 [axon cytoplasm]
GO:1904428 [negative regulation of tubulin deacetylation]
GO:1905689 [positive regulation of diacylglycerol kinase activity]
GO:1990000 [amyloid fibril formation]
GO:1990090 [cellular response to nerve growth factor stimulus]
GO:1990416 [cellular response to brain-derived neurotrophic factor stimulus]
GO:2001020 [regulation of response to DNA damage stimulus]
Show all
 776 aa
80.9 kDa 		No 0
MAPT-206
ENSP00000413056
ENST00000420682
P10636
[Direct mapping] Microtubule-associated protein tau
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0001774 [microglial cell activation]
GO:0003677 [DNA binding]
GO:0003680 [minor groove of adenine-thymine-rich DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003723 [RNA binding]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0006475 [internal protein amino acid acetylation]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007267 [cell-cell signaling]
GO:0007613 [memory]
GO:0008017 [microtubule binding]
GO:0010288 [response to lead ion]
GO:0010506 [regulation of autophagy]
GO:0010629 [negative regulation of gene expression]
GO:0010917 [negative regulation of mitochondrial membrane potential]
GO:0015630 [microtubule cytoskeleton]
GO:0015631 [tubulin binding]
GO:0016020 [membrane]
GO:0016072 [rRNA metabolic process]
GO:0016607 [nuclear speck]
GO:0017124 [SH3 domain binding]
GO:0019896 [axonal transport of mitochondrion]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0021954 [central nervous system neuron development]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0030673 [axolemma]
GO:0030674 [protein-macromolecule adaptor activity]
GO:0031110 [regulation of microtubule polymerization or depolymerization]
GO:0031113 [regulation of microtubule polymerization]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031122 [cytoplasmic microtubule organization]
GO:0031175 [neuron projection development]
GO:0032930 [positive regulation of superoxide anion generation]
GO:0033044 [regulation of chromosome organization]
GO:0033673 [negative regulation of kinase activity]
GO:0034063 [stress granule assembly]
GO:0034185 [apolipoprotein binding]
GO:0034399 [nuclear periphery]
GO:0034452 [dynactin binding]
GO:0034605 [cellular response to heat]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035091 [phosphatidylinositol binding]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0036477 [somatodendritic compartment]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043197 [dendritic spine]
GO:0043565 [sequence-specific DNA binding]
GO:0044297 [cell body]
GO:0044304 [main axon]
GO:0045121 [membrane raft]
GO:0045298 [tubulin complex]
GO:0045773 [positive regulation of axon extension]
GO:0046785 [microtubule polymerization]
GO:0048143 [astrocyte activation]
GO:0048167 [regulation of synaptic plasticity]
GO:0048312 [intracellular distribution of mitochondria]
GO:0048699 [generation of neurons]
GO:0050808 [synapse organization]
GO:0050848 [regulation of calcium-mediated signaling]
GO:0051087 [chaperone binding]
GO:0051258 [protein polymerization]
GO:0051721 [protein phosphatase 2A binding]
GO:0051879 [Hsp90 protein binding]
GO:0061564 [axon development]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0071813 [lipoprotein particle binding]
GO:0072386 [plus-end-directed organelle transport along microtubule]
GO:0090140 [regulation of mitochondrial fission]
GO:0090258 [negative regulation of mitochondrial fission]
GO:0097386 [glial cell projection]
GO:0097418 [neurofibrillary tangle]
GO:0097435 [supramolecular fiber organization]
GO:0098930 [axonal transport]
GO:0099077 [histone-dependent DNA binding]
GO:0099609 [microtubule lateral binding]
GO:1900034 [regulation of cellular response to heat]
GO:1900452 [regulation of long-term synaptic depression]
GO:1901216 [positive regulation of neuron death]
GO:1902474 [positive regulation of protein localization to synapse]
GO:1902936 [phosphatidylinositol bisphosphate binding]
GO:1902988 [neurofibrillary tangle assembly]
GO:1903748 [negative regulation of establishment of protein localization to mitochondrion]
GO:1903829 [positive regulation of protein localization]
GO:1904115 [axon cytoplasm]
GO:1904428 [negative regulation of tubulin deacetylation]
GO:1905689 [positive regulation of diacylglycerol kinase activity]
GO:1990000 [amyloid fibril formation]
GO:1990090 [cellular response to nerve growth factor stimulus]
GO:1990416 [cellular response to brain-derived neurotrophic factor stimulus]
GO:2001020 [regulation of response to DNA damage stimulus]
Show all
 412 aa
43 kDa 		No 0
MAPT-207
ENSP00000389250
ENST00000431008
P10636
[Direct mapping] Microtubule-associated protein tau
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0001774 [microglial cell activation]
GO:0003677 [DNA binding]
GO:0003680 [minor groove of adenine-thymine-rich DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003723 [RNA binding]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0006475 [internal protein amino acid acetylation]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007267 [cell-cell signaling]
GO:0007613 [memory]
GO:0008017 [microtubule binding]
GO:0010288 [response to lead ion]
GO:0010506 [regulation of autophagy]
GO:0010629 [negative regulation of gene expression]
GO:0010917 [negative regulation of mitochondrial membrane potential]
GO:0015630 [microtubule cytoskeleton]
GO:0015631 [tubulin binding]
GO:0016020 [membrane]
GO:0016072 [rRNA metabolic process]
GO:0016607 [nuclear speck]
GO:0017124 [SH3 domain binding]
GO:0019896 [axonal transport of mitochondrion]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0021954 [central nervous system neuron development]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0030673 [axolemma]
GO:0030674 [protein-macromolecule adaptor activity]
GO:0031110 [regulation of microtubule polymerization or depolymerization]
GO:0031113 [regulation of microtubule polymerization]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031122 [cytoplasmic microtubule organization]
GO:0031175 [neuron projection development]
GO:0032930 [positive regulation of superoxide anion generation]
GO:0033044 [regulation of chromosome organization]
GO:0033673 [negative regulation of kinase activity]
GO:0034063 [stress granule assembly]
GO:0034185 [apolipoprotein binding]
GO:0034399 [nuclear periphery]
GO:0034452 [dynactin binding]
GO:0034605 [cellular response to heat]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035091 [phosphatidylinositol binding]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0036477 [somatodendritic compartment]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043197 [dendritic spine]
GO:0043565 [sequence-specific DNA binding]
GO:0044297 [cell body]
GO:0044304 [main axon]
GO:0045121 [membrane raft]
GO:0045298 [tubulin complex]
GO:0045773 [positive regulation of axon extension]
GO:0046785 [microtubule polymerization]
GO:0048143 [astrocyte activation]
GO:0048167 [regulation of synaptic plasticity]
GO:0048312 [intracellular distribution of mitochondria]
GO:0048699 [generation of neurons]
GO:0050808 [synapse organization]
GO:0050848 [regulation of calcium-mediated signaling]
GO:0051087 [chaperone binding]
GO:0051258 [protein polymerization]
GO:0051721 [protein phosphatase 2A binding]
GO:0051879 [Hsp90 protein binding]
GO:0061564 [axon development]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0071813 [lipoprotein particle binding]
GO:0072386 [plus-end-directed organelle transport along microtubule]
GO:0090140 [regulation of mitochondrial fission]
GO:0090258 [negative regulation of mitochondrial fission]
GO:0097386 [glial cell projection]
GO:0097418 [neurofibrillary tangle]
GO:0097435 [supramolecular fiber organization]
GO:0098930 [axonal transport]
GO:0099077 [histone-dependent DNA binding]
GO:0099609 [microtubule lateral binding]
GO:1900034 [regulation of cellular response to heat]
GO:1900452 [regulation of long-term synaptic depression]
GO:1901216 [positive regulation of neuron death]
GO:1902474 [positive regulation of protein localization to synapse]
GO:1902936 [phosphatidylinositol bisphosphate binding]
GO:1902988 [neurofibrillary tangle assembly]
GO:1903748 [negative regulation of establishment of protein localization to mitochondrion]
GO:1903829 [positive regulation of protein localization]
GO:1904115 [axon cytoplasm]
GO:1904428 [negative regulation of tubulin deacetylation]
GO:1905689 [positive regulation of diacylglycerol kinase activity]
GO:1990000 [amyloid fibril formation]
GO:1990090 [cellular response to nerve growth factor stimulus]
GO:1990416 [cellular response to brain-derived neurotrophic factor stimulus]
GO:2001020 [regulation of response to DNA damage stimulus]
Show all
 410 aa
42.6 kDa 		No 0
MAPT-208
ENSP00000408975
ENST00000446361
P10636
[Direct mapping] Microtubule-associated protein tau
Show all
A0A024R9Y0
[Target identity:100%; Query identity:100%] Microtubule-associated protein
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0001774 [microglial cell activation]
GO:0003677 [DNA binding]
GO:0003680 [minor groove of adenine-thymine-rich DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003723 [RNA binding]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0006475 [internal protein amino acid acetylation]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007267 [cell-cell signaling]
GO:0007613 [memory]
GO:0008017 [microtubule binding]
GO:0010288 [response to lead ion]
GO:0010506 [regulation of autophagy]
GO:0010629 [negative regulation of gene expression]
GO:0010917 [negative regulation of mitochondrial membrane potential]
GO:0015630 [microtubule cytoskeleton]
GO:0015631 [tubulin binding]
GO:0016020 [membrane]
GO:0016072 [rRNA metabolic process]
GO:0016607 [nuclear speck]
GO:0017124 [SH3 domain binding]
GO:0019896 [axonal transport of mitochondrion]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0021954 [central nervous system neuron development]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0030673 [axolemma]
GO:0030674 [protein-macromolecule adaptor activity]
GO:0031110 [regulation of microtubule polymerization or depolymerization]
GO:0031113 [regulation of microtubule polymerization]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031122 [cytoplasmic microtubule organization]
GO:0031175 [neuron projection development]
GO:0032930 [positive regulation of superoxide anion generation]
GO:0033044 [regulation of chromosome organization]
GO:0033673 [negative regulation of kinase activity]
GO:0034063 [stress granule assembly]
GO:0034185 [apolipoprotein binding]
GO:0034399 [nuclear periphery]
GO:0034452 [dynactin binding]
GO:0034605 [cellular response to heat]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035091 [phosphatidylinositol binding]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0036477 [somatodendritic compartment]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043197 [dendritic spine]
GO:0043565 [sequence-specific DNA binding]
GO:0044297 [cell body]
GO:0044304 [main axon]
GO:0045121 [membrane raft]
GO:0045298 [tubulin complex]
GO:0045773 [positive regulation of axon extension]
GO:0046785 [microtubule polymerization]
GO:0048143 [astrocyte activation]
GO:0048167 [regulation of synaptic plasticity]
GO:0048312 [intracellular distribution of mitochondria]
GO:0048699 [generation of neurons]
GO:0050808 [synapse organization]
GO:0050848 [regulation of calcium-mediated signaling]
GO:0051087 [chaperone binding]
GO:0051258 [protein polymerization]
GO:0051721 [protein phosphatase 2A binding]
GO:0051879 [Hsp90 protein binding]
GO:0061564 [axon development]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0071813 [lipoprotein particle binding]
GO:0072386 [plus-end-directed organelle transport along microtubule]
GO:0090140 [regulation of mitochondrial fission]
GO:0090258 [negative regulation of mitochondrial fission]
GO:0097386 [glial cell projection]
GO:0097418 [neurofibrillary tangle]
GO:0097435 [supramolecular fiber organization]
GO:0098930 [axonal transport]
GO:0099077 [histone-dependent DNA binding]
GO:0099609 [microtubule lateral binding]
GO:1900034 [regulation of cellular response to heat]
GO:1900452 [regulation of long-term synaptic depression]
GO:1901216 [positive regulation of neuron death]
GO:1902474 [positive regulation of protein localization to synapse]
GO:1902936 [phosphatidylinositol bisphosphate binding]
GO:1902988 [neurofibrillary tangle assembly]
GO:1903748 [negative regulation of establishment of protein localization to mitochondrion]
GO:1903829 [positive regulation of protein localization]
GO:1904115 [axon cytoplasm]
GO:1904428 [negative regulation of tubulin deacetylation]
GO:1905689 [positive regulation of diacylglycerol kinase activity]
GO:1990000 [amyloid fibril formation]
GO:1990090 [cellular response to nerve growth factor stimulus]
GO:1990416 [cellular response to brain-derived neurotrophic factor stimulus]
GO:2001020 [regulation of response to DNA damage stimulus]
Show all
 383 aa
40 kDa 		No 0
MAPT-209
ENSP00000443028
ENST00000535772
P10636
[Direct mapping] Microtubule-associated protein tau
Show all
A0A024RA19
[Target identity:100%; Query identity:100%] Microtubule-associated protein
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0001774 [microglial cell activation]
GO:0003677 [DNA binding]
GO:0003680 [minor groove of adenine-thymine-rich DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003723 [RNA binding]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0006475 [internal protein amino acid acetylation]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007267 [cell-cell signaling]
GO:0007613 [memory]
GO:0008017 [microtubule binding]
GO:0010288 [response to lead ion]
GO:0010506 [regulation of autophagy]
GO:0010629 [negative regulation of gene expression]
GO:0010917 [negative regulation of mitochondrial membrane potential]
GO:0015630 [microtubule cytoskeleton]
GO:0015631 [tubulin binding]
GO:0016020 [membrane]
GO:0016072 [rRNA metabolic process]
GO:0016607 [nuclear speck]
GO:0017124 [SH3 domain binding]
GO:0019896 [axonal transport of mitochondrion]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0021954 [central nervous system neuron development]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0030673 [axolemma]
GO:0030674 [protein-macromolecule adaptor activity]
GO:0031110 [regulation of microtubule polymerization or depolymerization]
GO:0031113 [regulation of microtubule polymerization]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031122 [cytoplasmic microtubule organization]
GO:0031175 [neuron projection development]
GO:0032930 [positive regulation of superoxide anion generation]
GO:0033044 [regulation of chromosome organization]
GO:0033673 [negative regulation of kinase activity]
GO:0034063 [stress granule assembly]
GO:0034185 [apolipoprotein binding]
GO:0034399 [nuclear periphery]
GO:0034452 [dynactin binding]
GO:0034605 [cellular response to heat]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035091 [phosphatidylinositol binding]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0036477 [somatodendritic compartment]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043197 [dendritic spine]
GO:0043565 [sequence-specific DNA binding]
GO:0044297 [cell body]
GO:0044304 [main axon]
GO:0045121 [membrane raft]
GO:0045298 [tubulin complex]
GO:0045773 [positive regulation of axon extension]
GO:0046785 [microtubule polymerization]
GO:0048143 [astrocyte activation]
GO:0048167 [regulation of synaptic plasticity]
GO:0048312 [intracellular distribution of mitochondria]
GO:0048699 [generation of neurons]
GO:0050808 [synapse organization]
GO:0050848 [regulation of calcium-mediated signaling]
GO:0051087 [chaperone binding]
GO:0051258 [protein polymerization]
GO:0051721 [protein phosphatase 2A binding]
GO:0051879 [Hsp90 protein binding]
GO:0061564 [axon development]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0071813 [lipoprotein particle binding]
GO:0072386 [plus-end-directed organelle transport along microtubule]
GO:0090140 [regulation of mitochondrial fission]
GO:0090258 [negative regulation of mitochondrial fission]
GO:0097386 [glial cell projection]
GO:0097418 [neurofibrillary tangle]
GO:0097435 [supramolecular fiber organization]
GO:0098930 [axonal transport]
GO:0099077 [histone-dependent DNA binding]
GO:0099609 [microtubule lateral binding]
GO:1900034 [regulation of cellular response to heat]
GO:1900452 [regulation of long-term synaptic depression]
GO:1901216 [positive regulation of neuron death]
GO:1902474 [positive regulation of protein localization to synapse]
GO:1902936 [phosphatidylinositol bisphosphate binding]
GO:1902988 [neurofibrillary tangle assembly]
GO:1903748 [negative regulation of establishment of protein localization to mitochondrion]
GO:1903829 [positive regulation of protein localization]
GO:1904115 [axon cytoplasm]
GO:1904428 [negative regulation of tubulin deacetylation]
GO:1905689 [positive regulation of diacylglycerol kinase activity]
GO:1990000 [amyloid fibril formation]
GO:1990090 [cellular response to nerve growth factor stimulus]
GO:1990416 [cellular response to brain-derived neurotrophic factor stimulus]
GO:2001020 [regulation of response to DNA damage stimulus]
Show all
 381 aa
39.7 kDa 		No 0
MAPT-212
ENSP00000458742
ENST00000571987
P10636
[Direct mapping] Microtubule-associated protein tau
Show all
A0A024R9Y1
[Target identity:100%; Query identity:100%] Microtubule-associated protein
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0001774 [microglial cell activation]
GO:0003677 [DNA binding]
GO:0003680 [minor groove of adenine-thymine-rich DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003723 [RNA binding]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0006475 [internal protein amino acid acetylation]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007267 [cell-cell signaling]
GO:0007613 [memory]
GO:0008017 [microtubule binding]
GO:0010288 [response to lead ion]
GO:0010506 [regulation of autophagy]
GO:0010629 [negative regulation of gene expression]
GO:0010917 [negative regulation of mitochondrial membrane potential]
GO:0015630 [microtubule cytoskeleton]
GO:0015631 [tubulin binding]
GO:0016020 [membrane]
GO:0016072 [rRNA metabolic process]
GO:0016607 [nuclear speck]
GO:0017124 [SH3 domain binding]
GO:0019896 [axonal transport of mitochondrion]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0021954 [central nervous system neuron development]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0030673 [axolemma]
GO:0030674 [protein-macromolecule adaptor activity]
GO:0031110 [regulation of microtubule polymerization or depolymerization]
GO:0031113 [regulation of microtubule polymerization]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031122 [cytoplasmic microtubule organization]
GO:0031175 [neuron projection development]
GO:0032930 [positive regulation of superoxide anion generation]
GO:0033044 [regulation of chromosome organization]
GO:0033673 [negative regulation of kinase activity]
GO:0034063 [stress granule assembly]
GO:0034185 [apolipoprotein binding]
GO:0034399 [nuclear periphery]
GO:0034452 [dynactin binding]
GO:0034605 [cellular response to heat]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035091 [phosphatidylinositol binding]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0036477 [somatodendritic compartment]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043197 [dendritic spine]
GO:0043565 [sequence-specific DNA binding]
GO:0044297 [cell body]
GO:0044304 [main axon]
GO:0045121 [membrane raft]
GO:0045298 [tubulin complex]
GO:0045773 [positive regulation of axon extension]
GO:0046785 [microtubule polymerization]
GO:0048143 [astrocyte activation]
GO:0048167 [regulation of synaptic plasticity]
GO:0048312 [intracellular distribution of mitochondria]
GO:0048699 [generation of neurons]
GO:0050808 [synapse organization]
GO:0050848 [regulation of calcium-mediated signaling]
GO:0051087 [chaperone binding]
GO:0051258 [protein polymerization]
GO:0051721 [protein phosphatase 2A binding]
GO:0051879 [Hsp90 protein binding]
GO:0061564 [axon development]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0071813 [lipoprotein particle binding]
GO:0072386 [plus-end-directed organelle transport along microtubule]
GO:0090140 [regulation of mitochondrial fission]
GO:0090258 [negative regulation of mitochondrial fission]
GO:0097386 [glial cell projection]
GO:0097418 [neurofibrillary tangle]
GO:0097435 [supramolecular fiber organization]
GO:0098930 [axonal transport]
GO:0099077 [histone-dependent DNA binding]
GO:0099609 [microtubule lateral binding]
GO:1900034 [regulation of cellular response to heat]
GO:1900452 [regulation of long-term synaptic depression]
GO:1901216 [positive regulation of neuron death]
GO:1902474 [positive regulation of protein localization to synapse]
GO:1902936 [phosphatidylinositol bisphosphate binding]
GO:1902988 [neurofibrillary tangle assembly]
GO:1903748 [negative regulation of establishment of protein localization to mitochondrion]
GO:1903829 [positive regulation of protein localization]
GO:1904115 [axon cytoplasm]
GO:1904428 [negative regulation of tubulin deacetylation]
GO:1905689 [positive regulation of diacylglycerol kinase activity]
GO:1990000 [amyloid fibril formation]
GO:1990090 [cellular response to nerve growth factor stimulus]
GO:1990416 [cellular response to brain-derived neurotrophic factor stimulus]
GO:2001020 [regulation of response to DNA damage stimulus]
Show all
 758 aa
78.9 kDa 		No 0
MAPT-214
ENSP00000460965
ENST00000574436
P10636
[Direct mapping] Microtubule-associated protein tau
Show all
A0A024RA17
[Target identity:100%; Query identity:100%] Microtubule-associated protein
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Candidate cardiovascular disease genes
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000226 [microtubule cytoskeleton organization]
GO:0001774 [microglial cell activation]
GO:0003677 [DNA binding]
GO:0003680 [minor groove of adenine-thymine-rich DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0003723 [RNA binding]
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0006475 [internal protein amino acid acetylation]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007267 [cell-cell signaling]
GO:0007416 [synapse assembly]
GO:0007611 [learning or memory]
GO:0007613 [memory]
GO:0008017 [microtubule binding]
GO:0010288 [response to lead ion]
GO:0010506 [regulation of autophagy]
GO:0010629 [negative regulation of gene expression]
GO:0010917 [negative regulation of mitochondrial membrane potential]
GO:0015630 [microtubule cytoskeleton]
GO:0015631 [tubulin binding]
GO:0016020 [membrane]
GO:0016072 [rRNA metabolic process]
GO:0016607 [nuclear speck]
GO:0017124 [SH3 domain binding]
GO:0019896 [axonal transport of mitochondrion]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0021954 [central nervous system neuron development]
GO:0030424 [axon]
GO:0030425 [dendrite]
GO:0030426 [growth cone]
GO:0030673 [axolemma]
GO:0030674 [protein-macromolecule adaptor activity]
GO:0031110 [regulation of microtubule polymerization or depolymerization]
GO:0031113 [regulation of microtubule polymerization]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031122 [cytoplasmic microtubule organization]
GO:0031175 [neuron projection development]
GO:0032930 [positive regulation of superoxide anion generation]
GO:0033044 [regulation of chromosome organization]
GO:0033673 [negative regulation of kinase activity]
GO:0034063 [stress granule assembly]
GO:0034185 [apolipoprotein binding]
GO:0034399 [nuclear periphery]
GO:0034452 [dynactin binding]
GO:0034605 [cellular response to heat]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035091 [phosphatidylinositol binding]
GO:0036464 [cytoplasmic ribonucleoprotein granule]
GO:0036477 [somatodendritic compartment]
GO:0042802 [identical protein binding]
GO:0042995 [cell projection]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043197 [dendritic spine]
GO:0043565 [sequence-specific DNA binding]
GO:0044297 [cell body]
GO:0044304 [main axon]
GO:0045121 [membrane raft]
GO:0045298 [tubulin complex]
GO:0045773 [positive regulation of axon extension]
GO:0046785 [microtubule polymerization]
GO:0048143 [astrocyte activation]
GO:0048167 [regulation of synaptic plasticity]
GO:0048312 [intracellular distribution of mitochondria]
GO:0048699 [generation of neurons]
GO:0050808 [synapse organization]
GO:0050848 [regulation of calcium-mediated signaling]
GO:0051087 [chaperone binding]
GO:0051258 [protein polymerization]
GO:0051260 [protein homooligomerization]
GO:0051721 [protein phosphatase 2A binding]
GO:0051879 [Hsp90 protein binding]
GO:0061564 [axon development]
GO:0070507 [regulation of microtubule cytoskeleton organization]
GO:0071813 [lipoprotein particle binding]
GO:0072386 [plus-end-directed organelle transport along microtubule]
GO:0090140 [regulation of mitochondrial fission]
GO:0090258 [negative regulation of mitochondrial fission]
GO:0097386 [glial cell projection]
GO:0097418 [neurofibrillary tangle]
GO:0097435 [supramolecular fiber organization]
GO:0098930 [axonal transport]
GO:0099077 [histone-dependent DNA binding]
GO:0099609 [microtubule lateral binding]
GO:1900034 [regulation of cellular response to heat]
GO:1900452 [regulation of long-term synaptic depression]
GO:1901216 [positive regulation of neuron death]
GO:1902474 [positive regulation of protein localization to synapse]
GO:1902936 [phosphatidylinositol bisphosphate binding]
GO:1902988 [neurofibrillary tangle assembly]
GO:1903748 [negative regulation of establishment of protein localization to mitochondrion]
GO:1903829 [positive regulation of protein localization]
GO:1904115 [axon cytoplasm]
GO:1904428 [negative regulation of tubulin deacetylation]
GO:1905689 [positive regulation of diacylglycerol kinase activity]
GO:1990000 [amyloid fibril formation]
GO:1990090 [cellular response to nerve growth factor stimulus]
GO:1990416 [cellular response to brain-derived neurotrophic factor stimulus]
GO:2001020 [regulation of response to DNA damage stimulus]
Show all
 441 aa
45.8 kDa 		No 0
MAPT-218
ENSP00000505478
ENST00000680674
A0A7P0T936
[Direct mapping] Microtubule-associated protein
Show all
Predicted secreted proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Human disease related genes
   Nervous system diseases
   Neurodegenerative diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0008017 [microtubule binding]
GO:0015631 [tubulin binding]
GO:0016020 [membrane]
GO:0030424 [axon]
GO:0042995 [cell projection]
Show all
 424 aa
44.2 kDa 		No 0

Contact

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The Human Protein Atlas

The Human Protein Atlas project is funded
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contact@proteinatlas.org