Expression of NAP1L1 in urothelial cancer

BLADDER UROTHELIAL CARCINOMA (TCGA) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

NAP1L1 is not prognostic in Bladder Urothelial Carcinoma (TCGA)

Stage:

Survival analysis

Current cut offⁱ :

Best expression cut offⁱ : 321.71

Median expressionⁱ : N/A

Median follow up timeⁱ : N/A

P scoreⁱ N/A

5-year survival highⁱ N/A

5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average pTPM

433.2

Number of samples

169

Samples

Sample	Description	pTPM
TCGA-XF-A9T2-01A	54 years, male, white, stage:Stage III, dead, 575 days	2581.4
TCGA-XF-A9ST-01A	68 years, male, white, stage:Stage III, dead, 128 days	2465.7
TCGA-XF-A9SW-01A	85 years, male, white, stage:Stage IV, dead, 362 days	1662.4
TCGA-YC-A9TC-01A	71 years, male, white, stage:Stage IV, dead, 20 days	1647.3
TCGA-G2-AA3C-01A	66 years, male, white, stage:Stage IV, dead, 211 days	1492.7
TCGA-XF-A9SL-01A	69 years, male, white, stage:Stage IV, dead, 2020 days	1334.0
TCGA-GV-A40E-01A	75 years, male, white, stage:Stage II, dead, 261 days	1263.7
TCGA-XF-AAN4-01A	77 years, female, white, stage:Stage III, dead, 823 days	1263.1
TCGA-ZF-A9R9-01A	58 years, male, white, stage:Stage IV, dead, 864 days	1231.2
TCGA-XF-AAME-01A	64 years, female, white, stage:Stage II, dead, 2828 days	1164.0
TCGA-GC-A3I6-01A	45 years, male, white, stage:Stage III, dead, 630 days	1084.8
TCGA-DK-A3IM-01A	76 years, male, white, stage:Stage III, dead, 248 days	1046.5
TCGA-GU-A767-01A	81 years, male, white, stage:Stage IV, dead, 144 days	1014.8
TCGA-DK-A3IN-01A	72 years, male, white, stage:Stage III, dead, 250 days	985.2
TCGA-XF-A9SU-01A	74 years, female, white, stage:Stage IV, dead, 182 days	958.2
TCGA-DK-A3X2-01A	85 years, male, white, stage:Stage IV, dead, 547 days	918.8
TCGA-BT-A20P-01A	81 years, female, white, stage:Stage III, dead, 544 days	907.6
TCGA-BT-A20O-01A	75 years, male, white, stage:Stage III, dead, 370 days	904.6
TCGA-4Z-AA7S-01A	66 years, male, black or african american, stage:Stage III, dead, 1064 days	872.7
TCGA-XF-A9T8-01A	64 years, male, white, stage:Stage III, dead, 418 days	871.6
TCGA-BT-A20U-01A	70 years, female, white, stage:Stage III, dead, 455 days	866.8
TCGA-XF-A9SX-01A	63 years, female, white, stage:Stage IV, dead, 719 days	850.2
TCGA-FD-A62S-01A	60 years, female, black or african american, stage:Stage III, dead, 406 days	785.6
TCGA-ZF-AA52-01A	70 years, male, white, stage:Stage III, dead, 1077 days	778.6
TCGA-XF-AAMZ-01A	81 years, female, white, stage:Stage IV, dead, 1348 days	737.8
TCGA-E7-A541-01A	66 years, male, white, stage:Stage II, dead, 778 days	719.4
TCGA-DK-A2HX-01A	80 years, female, white, stage:Stage IV, dead, 1420 days	708.1
TCGA-ZF-A9RE-01A	78 years, female, white, stage:Stage II, dead, 106 days	706.0
TCGA-BL-A3JM-01A	62 years, male, white, stage:Stage III, dead, 205 days	705.1
TCGA-FD-A5BT-01A	84 years, male, white, stage:Stage III, dead, 328 days	705.0
TCGA-S5-A6DX-01A	83 years, male, white, stage:Stage IV, dead, 56 days	704.9
TCGA-XF-A9SV-01A	82 years, male, white, stage:Stage IV, dead, 388 days	690.4
TCGA-SY-A9G0-01A	82 years, male, white, stage:Stage IV, dead, 1008 days	682.4
TCGA-G2-A2EL-01A	77 years, male, white, stage:Stage II, dead, 819 days	674.8
TCGA-ZF-AA4R-01A	67 years, male, white, stage:Stage IV, dead, 1036 days	643.9
TCGA-FD-A3SL-01A	60 years, male, white, stage:Stage IV, dead, 712 days	637.4
TCGA-4Z-AA80-01A	73 years, male, white, stage:Stage II, dead, 19 days	635.6
TCGA-4Z-AA81-01A	80 years, male, white, stage:Stage II, dead, 1270 days	625.9
TCGA-ZF-AA4T-01A	65 years, male, white, stage:Stage IV, dead, 599 days	610.9
TCGA-XF-A9SJ-01A	83 years, male, white, stage:Stage IV, dead, 98 days	609.1
TCGA-XF-AAMJ-01A	70 years, male, asian, stage:Stage III, dead, 1670 days	599.2
TCGA-XF-AAMX-01A	87 years, female, black or african american, stage:Stage III, dead, 206 days	550.7
TCGA-XF-AAN7-01A	60 years, male, white, stage:Stage IV, dead, 565 days	528.5
TCGA-ZF-AA4N-01A	74 years, male, white, stage:Stage II, dead, 88 days	523.4
TCGA-BT-A20T-01A	63 years, male, white, stage:Stage IV, dead, 453 days	522.6
TCGA-FD-A3SR-01A	68 years, male, white, stage:Stage IV, dead, 602 days	520.1
TCGA-ZF-AA54-01A	71 years, male, white, stage:Stage III, dead, 590 days	515.2
TCGA-2F-A9KR-01A	59 years, female, stage:Stage III, dead, 3183 days	513.8
TCGA-BT-A20V-01A	59 years, female, black or african american, stage:Stage IV, dead, 154 days	504.1
TCGA-DK-AA6L-01A	48 years, male, white, stage:Stage IV, dead, 1163 days	495.0
TCGA-ZF-A9RN-01A	67 years, female, white, stage:Stage III, dead, 615 days	480.4
TCGA-BT-A20N-01A	72 years, male, stage:Stage III, dead, 795 days	471.0
TCGA-FD-A5BZ-01A	77 years, female, white, stage:Stage IV, dead, 835 days	464.6
TCGA-C4-A0EZ-01A	69 years, female, stage:Stage IV, dead, 273 days	443.4
TCGA-G2-A3IE-01A	51 years, male, white, stage:Stage II, dead, 612 days	428.7
TCGA-DK-AA6W-01A	78 years, male, white, stage:Stage II, dead, 415 days	427.5
TCGA-FD-A3SO-01A	68 years, male, white, stage:Stage IV, dead, 168 days	426.7
TCGA-BT-A20J-01A	75 years, male, white, stage:Stage II, dead, 579 days	420.7
TCGA-BT-A0S7-01A	75 years, male, white, stage:Stage III, dead, 200 days	409.3
TCGA-FJ-A871-01A	49 years, male, white, stage:Stage III, dead, 272 days	392.0
TCGA-XF-AAMH-01A	80 years, male, white, stage:Stage IV, dead, 344 days	392.0
TCGA-XF-AAN8-01A	74 years, female, white, stage:Stage III, dead, 118 days	376.9
TCGA-DK-A3IL-01A	79 years, female, white, stage:Stage IV, dead, 413 days	372.3
TCGA-G2-A2ES-01A	85 years, male, white, stage:Stage II, dead, 1004 days	356.4
TCGA-DK-A1A3-01A	60 years, male, white, stage:Stage IV, dead, 665 days	355.7
TCGA-4Z-AA82-01A	59 years, male, black or african american, stage:Stage IV, dead, 1556 days	354.0
TCGA-UY-A78N-01A	80 years, male, white, stage:Stage IV, dead, 2641 days	350.7
TCGA-HQ-A5ND-01A	78 years, male, stage:Stage IV, dead, 274 days	347.9
TCGA-G2-A2EO-01A	69 years, male, white, stage:Stage III, dead, 1804 days	343.9
TCGA-GU-A42P-01A	72 years, male, white, stage:Stage IV, dead, 332 days	342.8
TCGA-2F-A9KO-01A	63 years, male, white, stage:Stage IV, dead, 734 days	340.9
TCGA-2F-A9KP-01A	66 years, male, white, stage:Stage IV, dead, 364 days	324.1
TCGA-4Z-AA7N-01A	65 years, male, white, stage:Stage III, dead, 1367 days	322.6
TCGA-XF-AAMT-01A	75 years, female, white, stage:Stage IV, dead, 90 days	320.8
TCGA-XF-AAMW-01A	79 years, female, white, stage:Stage IV, dead, 253 days	319.2
TCGA-GC-A3BM-01A	70 years, male, white, stage:Stage II, dead, 651 days	309.2
TCGA-GU-A762-01A	87 years, male, white, stage:Stage IV, dead, 232 days	303.5
TCGA-FD-A3N5-01A	69 years, male, black or african american, stage:Stage II, dead, 685 days	300.1
TCGA-ZF-AA5N-01A	62 years, female, white, stage:Stage IV, dead, 168 days	298.3
TCGA-C4-A0F7-01A	77 years, male, stage:Stage IV, dead, 62 days	298.1
TCGA-2F-A9KW-01A	67 years, female, white, stage:Stage III, dead, 254 days	298.1
TCGA-DK-A3IQ-01A	74 years, male, white, stage:Stage III, dead, 539 days	295.5
TCGA-BT-A20W-01A	71 years, male, white, stage:Stage II, dead, 254 days	293.8
TCGA-FD-A5BX-01A	82 years, male, white, stage:Stage IV, dead, 173 days	289.7
TCGA-DK-A1A5-01A	79 years, male, white, stage:Stage II, dead, 65 days	283.1
TCGA-BL-A13J-01A	65 years, male, white, stage:Stage IV, dead, 81 days	279.5
TCGA-CU-A0YN-01A	60 years, male, white, stage:Stage III, dead, 393 days	278.9
TCGA-DK-A1AB-01A	74 years, female, white, stage:Stage IV, dead, 508 days	278.2
TCGA-FD-A3B4-01A	55 years, female, black or african american, stage:Stage III, dead, 510 days	276.5
TCGA-4Z-AA86-01A	66 years, male, black or african american, stage:Stage IV, dead, 311 days	268.7
TCGA-FD-A62O-01A	74 years, male, white, stage:Stage IV, dead, 216 days	258.3
TCGA-DK-A2I2-01A	63 years, female, white, stage:Stage IV, dead, 237 days	255.4
TCGA-BT-A3PK-01A	80 years, male, white, stage:Stage II, dead, 303 days	252.7
TCGA-G2-A2EC-01A	58 years, female, black or african american, stage:Stage II, dead, 696 days	247.0
TCGA-DK-A3IU-01A	58 years, male, white, stage:Stage II, dead, 706 days	246.0
TCGA-GU-A42Q-01A	67 years, male, white, stage:Stage III, dead, 344 days	244.4
TCGA-HQ-A5NE-01A	57 years, male, stage:Stage III, dead, 370 days	244.1
TCGA-FD-A3B7-01A	66 years, male, black or african american, stage:Stage III, dead, 122 days	236.0
TCGA-DK-AA6Q-01A	61 years, female, white, stage:Stage IV, dead, 413 days	234.7
TCGA-GU-A42R-01A	68 years, male, white, stage:Stage IV, dead, 577 days	233.8
TCGA-ZF-A9RD-01A	75 years, female, white, stage:Stage IV, dead, 408 days	233.6
TCGA-K4-A5RI-01A	67 years, female, white, stage:Stage III, dead, 356 days	233.2
TCGA-GU-AATQ-01A	68 years, male, white, stage:Stage III, dead, 213 days	230.9
TCGA-FD-A5BV-01A	47 years, female, white, stage:Stage III, dead, 163 days	230.6
TCGA-BT-A3PH-01A	76 years, male, white, stage:Stage IV, dead, 142 days	227.8
TCGA-FD-A3SJ-01A	59 years, male, white, stage:Stage IV, dead, 739 days	227.3
TCGA-4Z-AA7Q-01A	79 years, male, white, stage:Stage III, dead, 510 days	225.9
TCGA-4Z-AA7R-01A	73 years, male, black or african american, stage:Stage IV, dead, 522 days	225.1
TCGA-FD-A5C0-01A	61 years, male, white, stage:Stage IV, dead, 550 days	224.9
TCGA-FD-A6TF-01A	80 years, female, white, stage:Stage IV, dead, 69 days	219.1
TCGA-FD-A6TG-01A	73 years, male, white, stage:Stage IV, dead, 93 days	217.1
TCGA-XF-A8HI-01A	57 years, female, white, stage:Stage IV, dead, 544 days	215.8
TCGA-E5-A4TZ-01A	64 years, male, white, stage:Stage IV, dead, 467 days	215.5
TCGA-FD-A6TH-01A	63 years, male, white, stage:Stage IV, dead, 131 days	214.3
TCGA-E7-A97P-01A	73 years, male, asian, stage:Stage II, dead, 437 days	212.7
TCGA-ZF-AA56-01A	79 years, female, white, stage:Stage III, dead, 259 days	209.7
TCGA-FD-A3B3-01A	74 years, female, white, stage:Stage III, dead, 974 days	209.6
TCGA-CU-A0YR-01A	83 years, male, white, stage:Stage IV, dead, 460 days	207.3
TCGA-FD-A3B5-01A	86 years, male, black or african american, stage:Stage IV, dead, 272 days	206.9
TCGA-BT-A20Q-01A	73 years, male, white, stage:Stage IV, dead, 593 days	199.9
TCGA-FD-A3B6-01A	75 years, male, white, stage:Stage II, dead, 1005 days	198.9
TCGA-FD-A6TD-01A	77 years, male, white, stage:Stage III, dead, 386 days	198.0
TCGA-GV-A3QH-01A	67 years, male, white, stage:Stage II, dead, 258 days	197.8
TCGA-FD-A43Y-01A	65 years, male, white, stage:Stage III, dead, 474 days	195.9
TCGA-BL-A13I-01A	57 years, female, white, stage:Stage III, dead, 223 days	194.5
TCGA-CU-A5W6-01A	70 years, male, white, stage:Stage III, dead, 56 days	191.9
TCGA-XF-A9SH-01A	65 years, female, asian, stage:Stage II, dead, 1971 days	189.0
TCGA-FD-A62P-01A	76 years, male, white, stage:Stage II, dead, 191 days	188.7
TCGA-G2-A3IB-01A	66 years, male, black or african american, stage:Stage II, dead, 220 days	188.4
TCGA-UY-A78K-01A	60 years, male, white, stage:Stage IV, dead, 536 days	184.9
TCGA-BT-A2LB-01A	73 years, female, white, stage:Stage III, dead, 492 days	183.3
TCGA-CU-A0YO-01A	84 years, male, white, stage:Stage IV, dead, 149 days	183.0
TCGA-XF-A9SP-01A	59 years, male, white, stage:Stage III, dead, 454 days	178.9
TCGA-FD-A3SQ-01A	62 years, male, white, stage:Stage IV, dead, 1423 days	177.8
TCGA-CU-A72E-01A	76 years, male, white, stage:Stage IV, dead, 413 days	169.4
TCGA-ZF-A9R3-01A	53 years, female, white, stage:Stage II, dead, 949 days	164.8
TCGA-K4-A4AC-01A	83 years, male, white, stage:Stage II, dead, 278 days	163.9
TCGA-BT-A0YX-01A	70 years, female, white, stage:Stage III, dead, 400 days	163.6
TCGA-XF-A8HH-01A	61 years, female, white, stage:Stage IV, dead, 57 days	163.2
TCGA-E7-A3X6-01A	70 years, male, white, stage:Stage II, dead, 904 days	162.1
TCGA-XF-AAN1-01A	75 years, female, stage:Stage III, dead, 941 days	161.8
TCGA-XF-A9SZ-01A	79 years, male, white, stage:Stage IV, dead, 859 days	161.8
TCGA-5N-A9KM-01A	73 years, female, white, stage:Stage III, dead, 530 days	160.7
TCGA-BT-A20X-01A	56 years, male, white, stage:Stage IV, dead, 251 days	158.8
TCGA-XF-AAML-01A	75 years, male, white, stage:Stage II, dead, 232 days	158.6
TCGA-XF-AAN2-01A	73 years, male, white, stage:Stage II, dead, 1869 days	158.5
TCGA-XF-A9SK-01A	65 years, male, white, stage:Stage IV, dead, 486 days	151.7
TCGA-CF-A47T-01A	58 years, female, asian, stage:Stage II, dead, 385 days	151.1
TCGA-E7-A4XJ-01A	66 years, male, asian, stage:Stage II, dead, 68 days	150.2
TCGA-GV-A3JV-01A	66 years, male, white, stage:Stage IV, dead, 434 days	140.8
TCGA-GU-AATO-01A	75 years, male, white, stage:Stage IV, dead, 324 days	138.8
TCGA-5N-A9KI-01A	76 years, female, white, stage:Stage III, dead, 76 days	137.7
TCGA-UY-A78M-01A	81 years, female, asian, stage:Stage IV, dead, 690 days	135.5
TCGA-FD-A6TI-01A	73 years, male, white, stage:Stage IV, dead, 294 days	133.4
TCGA-FJ-A3ZE-01A	65 years, male, white, stage:Stage IV, dead, 324 days	133.2
TCGA-FD-A3SM-01A	70 years, male, white, stage:Stage IV, dead, 547 days	133.0
TCGA-XF-AAN0-01A	68 years, male, white, stage:Stage IV, dead, 1718 days	132.7
TCGA-GV-A3QF-01A	79 years, male, white, stage:Stage IV, dead, 617 days	132.5
TCGA-FJ-A3Z9-01A	72 years, male, white, stage:'--, dead, 385 days	121.6
TCGA-XF-A8HG-01A	69 years, male, white, stage:Stage III, dead, 467 days	119.9
TCGA-XF-A8HC-01A	79 years, male, asian, stage:Stage IV, dead, 200 days	119.1
TCGA-BT-A2LD-01A	78 years, female, white, stage:Stage IV, dead, 623 days	116.9
TCGA-FD-A3SS-01A	66 years, male, white, stage:Stage IV, dead, 391 days	108.0
TCGA-ZF-AA4U-01A	70 years, male, white, stage:Stage III, dead, 262 days	103.7
TCGA-XF-A8HF-01A	80 years, male, white, stage:Stage III, dead, 2954 days	101.3
TCGA-DK-AA75-01A	82 years, male, white, stage:Stage III, dead, 340 days	98.6
TCGA-DK-A3IK-01A	87 years, male, white, stage:Stage IV, dead, 146 days	97.9
TCGA-CF-A9FL-01A	85 years, male, asian, stage:Stage III, dead, 565 days	95.5
TCGA-ZF-A9R0-01A	82 years, male, white, stage:Stage III, dead, 680 days	67.4
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UROTHELIAL CANCER - Protein expressionⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.	Antibody HPA028861
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Urothelial carcinoma, Low grade
Urothelial carcinoma, High grade