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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Protein kinase cAMP-dependent type I regulatory subunit beta
Protein classi
Assigned HPA protein class(es) for the encoded protein(s).
Disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
7
Cytoband
p22.3
Chromosome location (bp)
549197 - 727650
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells....show less
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
cAMP, cAMP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a regulatory subunit of cyclic AMP-dependent protein kinase A (PKA), which is involved in the signaling pathway of the second messenger cAMP. Two regulatory and two catalytic subunits form the PKA holoenzyme, disbands after cAMP binding. The holoenzyme is involved in many cellular events, including ion transport, metabolism, and transcription. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2015]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P31321 [Direct mapping] cAMP-dependent protein kinase type I-beta regulatory subunit
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Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
H7BYW5 [Direct mapping] cAMP-dependent protein kinase type I-beta regulatory subunit
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SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
P31321 [Direct mapping] cAMP-dependent protein kinase type I-beta regulatory subunit
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P31321 [Direct mapping] cAMP-dependent protein kinase type I-beta regulatory subunit
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
P31321 [Direct mapping] cAMP-dependent protein kinase type I-beta regulatory subunit
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0001932[regulation of protein phosphorylation] GO:0004862[cAMP-dependent protein kinase inhibitor activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005771[multivesicular body] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0005952[cAMP-dependent protein kinase complex] GO:0006468[protein phosphorylation] GO:0007611[learning or memory] GO:0008603[cAMP-dependent protein kinase regulator activity] GO:0016020[membrane] GO:0030552[cAMP binding] GO:0034236[protein kinase A catalytic subunit binding] GO:0045202[synapse] GO:0045859[regulation of protein kinase activity] GO:0050804[modulation of chemical synaptic transmission] GO:0097546[ciliary base] GO:0098685[Schaffer collateral - CA1 synapse] GO:0098686[hippocampal mossy fiber to CA3 synapse] GO:0098693[regulation of synaptic vesicle cycle] GO:0098794[postsynapse] GO:0098978[glutamatergic synapse] GO:0140678[molecular function inhibitor activity] GO:1900273[positive regulation of long-term synaptic potentiation] GO:1903367[positive regulation of fear response] GO:1904058[positive regulation of sensory perception of pain] GO:2000463[positive regulation of excitatory postsynaptic potential] GO:2000480[negative regulation of cAMP-dependent protein kinase activity]
P31321 [Direct mapping] cAMP-dependent protein kinase type I-beta regulatory subunit
Show all
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
