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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Metabolic proteins Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
10
Cytoband
p15.1
Chromosome location (bp)
5035354 - 5107686
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Acts as a NAD(P)(H)-dependent 3-, 17- and 20-ketosteroid reductase on the steroid nucleus and side chain and regulates the metabolism of androgens, estrogens and progesterone 1,2,3,4,5. Displays the ability to catalyze both oxidation and reduction in vitro, but most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentration of NADPH 6,7. Acts preferentially as a 17-ketosteroid reductase and has the highest catalytic efficiency of the AKR1C enzyme for the reduction of delta4-androstenedione to form testosterone 8. Reduces prostaglandin (PG) D2 to 11beta-prostaglandin F2, progesterone to 20alpha-hydroxyprogesterone and estrone to 17beta-estradiol 9,10,11,12,13,14. Catalyzes the transformation of the potent androgen dihydrotestosterone (DHT) into the less active form, 5-alpha-androstan-3-alpha,17-beta-diol (3-alpha-diol) 15,16,17,18,19,20. Also displays retinaldehyde reductase activity toward 9-cis-retinal 21....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Oxidoreductase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Lipid metabolism
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
NAD, NADP
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P42330 [Direct mapping] Aldo-keto reductase family 1 member C3
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Enzymes ENZYME proteins Oxidoreductases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001523[retinoid metabolic process] GO:0001758[retinal dehydrogenase activity] GO:0004032[alditol:NADP+ 1-oxidoreductase activity] GO:0004033[aldo-keto reductase (NADP) activity] GO:0004303[estradiol 17-beta-dehydrogenase activity] GO:0004745[NAD-retinol dehydrogenase activity] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0006629[lipid metabolic process] GO:0006693[prostaglandin metabolic process] GO:0007186[G protein-coupled receptor signaling pathway] GO:0007584[response to nutrient] GO:0008202[steroid metabolic process] GO:0008284[positive regulation of cell population proliferation] GO:0008584[male gonad development] GO:0009267[cellular response to starvation] GO:0010942[positive regulation of cell death] GO:0016229[steroid dehydrogenase activity] GO:0016488[farnesol catabolic process] GO:0016491[oxidoreductase activity] GO:0016655[oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor] GO:0018636[phenanthrene 9,10-monooxygenase activity] GO:0019371[cyclooxygenase pathway] GO:0030216[keratinocyte differentiation] GO:0032052[bile acid binding] GO:0034614[cellular response to reactive oxygen species] GO:0035410[dihydrotestosterone 17-beta-dehydrogenase activity] GO:0036130[prostaglandin H2 endoperoxidase reductase activity] GO:0036131[prostaglandin D2 11-ketoreductase activity] GO:0042448[progesterone metabolic process] GO:0042572[retinol metabolic process] GO:0042574[retinal metabolic process] GO:0043170[macromolecule metabolic process] GO:0044594[17-beta-hydroxysteroid dehydrogenase (NAD+) activity] GO:0044597[daunorubicin metabolic process] GO:0044598[doxorubicin metabolic process] GO:0045550[geranylgeranyl reductase activity] GO:0045703[ketoreductase activity] GO:0047017[prostaglandin-F synthase activity] GO:0047020[15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity] GO:0047023[androsterone dehydrogenase activity] GO:0047024[5alpha-androstane-3beta,17beta-diol dehydrogenase activity] GO:0047035[testosterone dehydrogenase (NAD+) activity] GO:0047044[androstan-3-alpha,17-beta-diol dehydrogenase activity] GO:0047045[testosterone 17-beta-dehydrogenase (NADP+) activity] GO:0047086[ketosteroid monooxygenase activity] GO:0047787[delta4-3-oxosteroid 5beta-reductase activity] GO:0048385[regulation of retinoic acid receptor signaling pathway] GO:0051897[positive regulation of protein kinase B signaling] GO:0052650[NADP-retinol dehydrogenase activity] GO:0061370[testosterone biosynthetic process] GO:0070062[extracellular exosome] GO:0070293[renal absorption] GO:0071276[cellular response to cadmium ion] GO:0071277[cellular response to calcium ion] GO:0071379[cellular response to prostaglandin stimulus] GO:0071384[cellular response to corticosteroid stimulus] GO:0071395[cellular response to jasmonic acid stimulus] GO:0071799[cellular response to prostaglandin D stimulus] GO:1900053[negative regulation of retinoic acid biosynthetic process] GO:2000224[regulation of testosterone biosynthetic process] GO:2000353[positive regulation of endothelial cell apoptotic process] GO:2000379[positive regulation of reactive oxygen species metabolic process]
A0A0A0MSS8 [Direct mapping] Aldo-keto reductase family 1 member C3
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
S4R3Z2 [Direct mapping] Aldo-keto reductase family 1 member C3; Aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II), isoform CRA_a
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
