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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes FDA approved drug targets Metabolic proteins Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
7
Cytoband
p13
Chromosome location (bp)
44796680 - 44824564
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides 1,2,3,4,5. Exerts a strong chemotactic effect on leukocytes partly through activation of one of its membrane receptors BSG/CD147, initiating a signaling cascade that culminates in MAPK/ERK activation 6,7. Activates endothelial cells (ECs) in a pro-inflammatory manner by stimulating activation of NF-kappa-B and ERK, JNK and p38 MAP-kinases and by inducing expression of adhesion molecules including SELE and VCAM1 8. Induces apoptosis in ECs by promoting the FOXO1-dependent expression of CCL2 and BCL2L11 which are involved in EC chemotaxis and apoptosis 9. In response to oxidative stress, initiates proapoptotic and antiapoptotic signaling in ECs via activation of NF-kappa-B and AKT1 and up-regulation of antiapoptotic protein BCL2 10. Negatively regulates MAP3K5/ASK1 kinase activity, autophosphorylation and oxidative stress-induced apoptosis mediated by MAP3K5/ASK1 11. Necessary for the assembly of TARDBP in heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and regulates TARDBP binding to RNA UG repeats and TARDBP-dependent expression of HDAC6, ATG7 and VCP which are involved in clearance of protein aggregates 12. Plays an important role in platelet activation and aggregation (By similarity). Regulates calcium mobilization and integrin ITGA2B:ITGB3 bidirectional signaling via increased ROS production as well as by facilitating the interaction between integrin and the cell cytoskeleton (By similarity). Binds heparan sulfate glycosaminoglycans 13. Inhibits replication of influenza A virus (IAV) 14. Inhibits ITCH/AIP4-mediated ubiquitination of matrix protein 1 (M1) of IAV by impairing the interaction of ITCH/AIP4 with M1, followed by the suppression of the nuclear export of M1, and finally reduction of the replication of IAV 15,16....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Isomerase, Rotamase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis, Host-virus interaction
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported. [provided by RefSeq, Jul 2008]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P62937 [Direct mapping] Peptidyl-prolyl cis-trans isomerase A Peptidyl-prolyl cis-trans isomerase A, N-terminally processed
Show all
Enzymes ENZYME proteins Isomerase Metabolic proteins Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413[protein peptidyl-prolyl isomerization] GO:0001933[negative regulation of protein phosphorylation] GO:0001934[positive regulation of protein phosphorylation] GO:0003723[RNA binding] GO:0003755[peptidyl-prolyl cis-trans isomerase activity] GO:0005178[integrin binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005925[focal adhesion] GO:0006457[protein folding] GO:0006469[negative regulation of protein kinase activity] GO:0006915[apoptotic process] GO:0016018[cyclosporin A binding] GO:0016020[membrane] GO:0016853[isomerase activity] GO:0019076[viral release from host cell] GO:0030168[platelet activation] GO:0030593[neutrophil chemotaxis] GO:0030595[leukocyte chemotaxis] GO:0031982[vesicle] GO:0032148[activation of protein kinase B activity] GO:0032873[negative regulation of stress-activated MAPK cascade] GO:0032991[protein-containing complex] GO:0034389[lipid droplet organization] GO:0034599[cellular response to oxidative stress] GO:0034774[secretory granule lumen] GO:0035307[positive regulation of protein dephosphorylation] GO:0042118[endothelial cell activation] GO:0043231[intracellular membrane-bounded organelle] GO:0043410[positive regulation of MAPK cascade] GO:0045069[regulation of viral genome replication] GO:0045070[positive regulation of viral genome replication] GO:0046790[virion binding] GO:0050714[positive regulation of protein secretion] GO:0051082[unfolded protein binding] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060352[cell adhesion molecule production] GO:0061944[negative regulation of protein K48-linked ubiquitination] GO:0070062[extracellular exosome] GO:0070527[platelet aggregation] GO:1902176[negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1903901[negative regulation of viral life cycle] GO:1904399[heparan sulfate binding] GO:1904813[ficolin-1-rich granule lumen] GO:2001233[regulation of apoptotic signaling pathway]
Metabolic proteins Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Isomerase Metabolic proteins Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000413[protein peptidyl-prolyl isomerization] GO:0001933[negative regulation of protein phosphorylation] GO:0001934[positive regulation of protein phosphorylation] GO:0003723[RNA binding] GO:0003755[peptidyl-prolyl cis-trans isomerase activity] GO:0005178[integrin binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005925[focal adhesion] GO:0006457[protein folding] GO:0006469[negative regulation of protein kinase activity] GO:0006915[apoptotic process] GO:0016018[cyclosporin A binding] GO:0016020[membrane] GO:0016853[isomerase activity] GO:0019076[viral release from host cell] GO:0030168[platelet activation] GO:0030593[neutrophil chemotaxis] GO:0030595[leukocyte chemotaxis] GO:0031982[vesicle] GO:0032148[activation of protein kinase B activity] GO:0032873[negative regulation of stress-activated MAPK cascade] GO:0032991[protein-containing complex] GO:0034389[lipid droplet organization] GO:0034599[cellular response to oxidative stress] GO:0034774[secretory granule lumen] GO:0035307[positive regulation of protein dephosphorylation] GO:0042118[endothelial cell activation] GO:0043231[intracellular membrane-bounded organelle] GO:0043410[positive regulation of MAPK cascade] GO:0045069[regulation of viral genome replication] GO:0045070[positive regulation of viral genome replication] GO:0046790[virion binding] GO:0050714[positive regulation of protein secretion] GO:0051082[unfolded protein binding] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060352[cell adhesion molecule production] GO:0061944[negative regulation of protein K48-linked ubiquitination] GO:0070062[extracellular exosome] GO:0070527[platelet aggregation] GO:1902176[negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1903901[negative regulation of viral life cycle] GO:1904399[heparan sulfate binding] GO:1904813[ficolin-1-rich granule lumen] GO:2001233[regulation of apoptotic signaling pathway]
P62937 [Direct mapping] Peptidyl-prolyl cis-trans isomerase A Peptidyl-prolyl cis-trans isomerase A, N-terminally processed
Show all
Enzymes ENZYME proteins Isomerase Metabolic proteins Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413[protein peptidyl-prolyl isomerization] GO:0001933[negative regulation of protein phosphorylation] GO:0001934[positive regulation of protein phosphorylation] GO:0003723[RNA binding] GO:0003755[peptidyl-prolyl cis-trans isomerase activity] GO:0005178[integrin binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005925[focal adhesion] GO:0006457[protein folding] GO:0006469[negative regulation of protein kinase activity] GO:0006915[apoptotic process] GO:0016018[cyclosporin A binding] GO:0016020[membrane] GO:0016853[isomerase activity] GO:0019076[viral release from host cell] GO:0030168[platelet activation] GO:0030593[neutrophil chemotaxis] GO:0030595[leukocyte chemotaxis] GO:0031982[vesicle] GO:0032148[activation of protein kinase B activity] GO:0032873[negative regulation of stress-activated MAPK cascade] GO:0032991[protein-containing complex] GO:0034389[lipid droplet organization] GO:0034599[cellular response to oxidative stress] GO:0034774[secretory granule lumen] GO:0035307[positive regulation of protein dephosphorylation] GO:0042118[endothelial cell activation] GO:0043231[intracellular membrane-bounded organelle] GO:0043410[positive regulation of MAPK cascade] GO:0045069[regulation of viral genome replication] GO:0045070[positive regulation of viral genome replication] GO:0046790[virion binding] GO:0050714[positive regulation of protein secretion] GO:0051082[unfolded protein binding] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060352[cell adhesion molecule production] GO:0061944[negative regulation of protein K48-linked ubiquitination] GO:0070062[extracellular exosome] GO:0070527[platelet aggregation] GO:1902176[negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1903901[negative regulation of viral life cycle] GO:1904399[heparan sulfate binding] GO:1904813[ficolin-1-rich granule lumen] GO:2001233[regulation of apoptotic signaling pathway]
A0A7P0S768 [Direct mapping] Peptidyl-prolyl cis-trans isomerase A
Show all
Metabolic proteins Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
P62937 [Direct mapping] Peptidyl-prolyl cis-trans isomerase A Peptidyl-prolyl cis-trans isomerase A, N-terminally processed
Show all
Enzymes ENZYME proteins Isomerase Metabolic proteins Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413[protein peptidyl-prolyl isomerization] GO:0001933[negative regulation of protein phosphorylation] GO:0001934[positive regulation of protein phosphorylation] GO:0003723[RNA binding] GO:0003755[peptidyl-prolyl cis-trans isomerase activity] GO:0005178[integrin binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005925[focal adhesion] GO:0006457[protein folding] GO:0006469[negative regulation of protein kinase activity] GO:0006915[apoptotic process] GO:0016018[cyclosporin A binding] GO:0016020[membrane] GO:0016853[isomerase activity] GO:0019076[viral release from host cell] GO:0030168[platelet activation] GO:0030593[neutrophil chemotaxis] GO:0030595[leukocyte chemotaxis] GO:0031982[vesicle] GO:0032148[activation of protein kinase B activity] GO:0032873[negative regulation of stress-activated MAPK cascade] GO:0032991[protein-containing complex] GO:0034389[lipid droplet organization] GO:0034599[cellular response to oxidative stress] GO:0034774[secretory granule lumen] GO:0035307[positive regulation of protein dephosphorylation] GO:0042118[endothelial cell activation] GO:0043231[intracellular membrane-bounded organelle] GO:0043410[positive regulation of MAPK cascade] GO:0045069[regulation of viral genome replication] GO:0045070[positive regulation of viral genome replication] GO:0046790[virion binding] GO:0050714[positive regulation of protein secretion] GO:0051082[unfolded protein binding] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060352[cell adhesion molecule production] GO:0061944[negative regulation of protein K48-linked ubiquitination] GO:0070062[extracellular exosome] GO:0070527[platelet aggregation] GO:1902176[negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1903901[negative regulation of viral life cycle] GO:1904399[heparan sulfate binding] GO:1904813[ficolin-1-rich granule lumen] GO:2001233[regulation of apoptotic signaling pathway]
P62937 [Direct mapping] Peptidyl-prolyl cis-trans isomerase A Peptidyl-prolyl cis-trans isomerase A, N-terminally processed
Show all
Enzymes ENZYME proteins Isomerase Metabolic proteins Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413[protein peptidyl-prolyl isomerization] GO:0001933[negative regulation of protein phosphorylation] GO:0001934[positive regulation of protein phosphorylation] GO:0003723[RNA binding] GO:0003755[peptidyl-prolyl cis-trans isomerase activity] GO:0005178[integrin binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005925[focal adhesion] GO:0006457[protein folding] GO:0006469[negative regulation of protein kinase activity] GO:0006915[apoptotic process] GO:0016018[cyclosporin A binding] GO:0016020[membrane] GO:0016853[isomerase activity] GO:0019076[viral release from host cell] GO:0030168[platelet activation] GO:0030593[neutrophil chemotaxis] GO:0030595[leukocyte chemotaxis] GO:0031982[vesicle] GO:0032148[activation of protein kinase B activity] GO:0032873[negative regulation of stress-activated MAPK cascade] GO:0032991[protein-containing complex] GO:0034389[lipid droplet organization] GO:0034599[cellular response to oxidative stress] GO:0034774[secretory granule lumen] GO:0035307[positive regulation of protein dephosphorylation] GO:0042118[endothelial cell activation] GO:0043231[intracellular membrane-bounded organelle] GO:0043410[positive regulation of MAPK cascade] GO:0045069[regulation of viral genome replication] GO:0045070[positive regulation of viral genome replication] GO:0046790[virion binding] GO:0050714[positive regulation of protein secretion] GO:0051082[unfolded protein binding] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060352[cell adhesion molecule production] GO:0061944[negative regulation of protein K48-linked ubiquitination] GO:0070062[extracellular exosome] GO:0070527[platelet aggregation] GO:1902176[negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1903901[negative regulation of viral life cycle] GO:1904399[heparan sulfate binding] GO:1904813[ficolin-1-rich granule lumen] GO:2001233[regulation of apoptotic signaling pathway]
P62937 [Direct mapping] Peptidyl-prolyl cis-trans isomerase A Peptidyl-prolyl cis-trans isomerase A, N-terminally processed
Show all
Enzymes ENZYME proteins Isomerase Metabolic proteins Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413[protein peptidyl-prolyl isomerization] GO:0001933[negative regulation of protein phosphorylation] GO:0001934[positive regulation of protein phosphorylation] GO:0003723[RNA binding] GO:0003755[peptidyl-prolyl cis-trans isomerase activity] GO:0005178[integrin binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005925[focal adhesion] GO:0006457[protein folding] GO:0006469[negative regulation of protein kinase activity] GO:0006915[apoptotic process] GO:0016018[cyclosporin A binding] GO:0016020[membrane] GO:0016853[isomerase activity] GO:0019076[viral release from host cell] GO:0030168[platelet activation] GO:0030593[neutrophil chemotaxis] GO:0030595[leukocyte chemotaxis] GO:0031982[vesicle] GO:0032148[activation of protein kinase B activity] GO:0032873[negative regulation of stress-activated MAPK cascade] GO:0032991[protein-containing complex] GO:0034389[lipid droplet organization] GO:0034599[cellular response to oxidative stress] GO:0034774[secretory granule lumen] GO:0035307[positive regulation of protein dephosphorylation] GO:0042118[endothelial cell activation] GO:0043231[intracellular membrane-bounded organelle] GO:0043410[positive regulation of MAPK cascade] GO:0045069[regulation of viral genome replication] GO:0045070[positive regulation of viral genome replication] GO:0046790[virion binding] GO:0050714[positive regulation of protein secretion] GO:0051082[unfolded protein binding] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060352[cell adhesion molecule production] GO:0061944[negative regulation of protein K48-linked ubiquitination] GO:0070062[extracellular exosome] GO:0070527[platelet aggregation] GO:1902176[negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1903901[negative regulation of viral life cycle] GO:1904399[heparan sulfate binding] GO:1904813[ficolin-1-rich granule lumen] GO:2001233[regulation of apoptotic signaling pathway]
P62937 [Direct mapping] Peptidyl-prolyl cis-trans isomerase A Peptidyl-prolyl cis-trans isomerase A, N-terminally processed
Show all
Enzymes ENZYME proteins Isomerase Metabolic proteins Predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413[protein peptidyl-prolyl isomerization] GO:0001933[negative regulation of protein phosphorylation] GO:0001934[positive regulation of protein phosphorylation] GO:0003723[RNA binding] GO:0003755[peptidyl-prolyl cis-trans isomerase activity] GO:0005178[integrin binding] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005925[focal adhesion] GO:0006457[protein folding] GO:0006469[negative regulation of protein kinase activity] GO:0006915[apoptotic process] GO:0016018[cyclosporin A binding] GO:0016020[membrane] GO:0016853[isomerase activity] GO:0019076[viral release from host cell] GO:0030168[platelet activation] GO:0030593[neutrophil chemotaxis] GO:0030595[leukocyte chemotaxis] GO:0031982[vesicle] GO:0032148[activation of protein kinase B activity] GO:0032873[negative regulation of stress-activated MAPK cascade] GO:0032991[protein-containing complex] GO:0034389[lipid droplet organization] GO:0034599[cellular response to oxidative stress] GO:0034774[secretory granule lumen] GO:0035307[positive regulation of protein dephosphorylation] GO:0042118[endothelial cell activation] GO:0043231[intracellular membrane-bounded organelle] GO:0043410[positive regulation of MAPK cascade] GO:0045069[regulation of viral genome replication] GO:0045070[positive regulation of viral genome replication] GO:0046790[virion binding] GO:0050714[positive regulation of protein secretion] GO:0051082[unfolded protein binding] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0060352[cell adhesion molecule production] GO:0061944[negative regulation of protein K48-linked ubiquitination] GO:0070062[extracellular exosome] GO:0070527[platelet aggregation] GO:1902176[negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway] GO:1903901[negative regulation of viral life cycle] GO:1904399[heparan sulfate binding] GO:1904813[ficolin-1-rich granule lumen] GO:2001233[regulation of apoptotic signaling pathway]
The Human Protein Atlas project is funded
