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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Blood group antigen proteins CD markers Disease related genes Human disease related genes Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
1
Cytoband
q32.2
Chromosome location (bp)
207321519 - 207386804
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
This protein recognizes C4b and C3b fragments that condense with cell-surface hydroxyl or amino groups when nascent C4b and C3b are locally generated during C4 and c3 activation. Interaction of daf with cell-associated C4b and C3b polypeptides interferes with their ability to catalyze the conversion of C2 and factor B to enzymatically active C2a and Bb and thereby prevents the formation of C4b2a and C3bBb, the amplification convertases of the complement cascade 1. Inhibits complement activation by destabilizing and preventing the formation of C3 and C5 convertases, which prevents complement damage 2....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Blood group antigen, Host cell receptor for virus entry, Receptor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
This gene encodes a glycoprotein involved in the regulation of the complement cascade. Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in multiple transcript variants. The predominant transcript variant encodes a membrane-bound protein, but alternatively spliced transcripts may produce soluble proteins. [provided by RefSeq, Jul 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
CD markers Blood group antigen proteins MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins DeepSig predicted secreted proteins Plasma proteins Disease related genes Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000139[Golgi membrane] GO:0001618[virus receptor activity] GO:0002376[immune system process] GO:0002456[T cell mediated immunity] GO:0002726[positive regulation of T cell cytokine production] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005886[plasma membrane] GO:0006958[complement activation, classical pathway] GO:0007204[positive regulation of cytosolic calcium ion concentration] GO:0008289[lipid binding] GO:0009986[cell surface] GO:0016020[membrane] GO:0030133[transport vesicle] GO:0030449[regulation of complement activation] GO:0030667[secretory granule membrane] GO:0031664[regulation of lipopolysaccharide-mediated signaling pathway] GO:0033116[endoplasmic reticulum-Golgi intermediate compartment membrane] GO:0045087[innate immune response] GO:0045121[membrane raft] GO:0045730[respiratory burst] GO:0045916[negative regulation of complement activation] GO:0045959[negative regulation of complement activation, classical pathway] GO:0046718[viral entry into host cell] GO:0070062[extracellular exosome] GO:0101003[ficolin-1-rich granule membrane] GO:1903659[regulation of complement-dependent cytotoxicity] GO:2000516[positive regulation of CD4-positive, alpha-beta T cell activation] GO:2000563[positive regulation of CD4-positive, alpha-beta T cell proliferation]
CD markers Blood group antigen proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Disease related genes Human disease related genes Immune system diseases Primary immunodeficiency Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000139[Golgi membrane] GO:0001618[virus receptor activity] GO:0002376[immune system process] GO:0002456[T cell mediated immunity] GO:0002726[positive regulation of T cell cytokine production] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005886[plasma membrane] GO:0006958[complement activation, classical pathway] GO:0007204[positive regulation of cytosolic calcium ion concentration] GO:0008289[lipid binding] GO:0009986[cell surface] GO:0016020[membrane] GO:0030133[transport vesicle] GO:0030449[regulation of complement activation] GO:0030667[secretory granule membrane] GO:0031664[regulation of lipopolysaccharide-mediated signaling pathway] GO:0033116[endoplasmic reticulum-Golgi intermediate compartment membrane] GO:0045087[innate immune response] GO:0045121[membrane raft] GO:0045730[respiratory burst] GO:0045916[negative regulation of complement activation] GO:0045959[negative regulation of complement activation, classical pathway] GO:0046718[viral entry into host cell] GO:0070062[extracellular exosome] GO:0101003[ficolin-1-rich granule membrane] GO:1903659[regulation of complement-dependent cytotoxicity] GO:2000516[positive regulation of CD4-positive, alpha-beta T cell activation] GO:2000563[positive regulation of CD4-positive, alpha-beta T cell proliferation]
Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Human disease related genes Immune system diseases Primary immunodeficiency Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
