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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Enzymes FDA approved drug targets Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
6
Cytoband
q21
Chromosome location (bp)
113933028 - 114011308
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) 1. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). Histone deacetylases act via the formation of large multiprotein complexes (By similarity). Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR 2. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development (By similarity). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin 3,4. Component of the SIN3B complex that represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 5. Also deacetylates non-histone targets: deacetylates TSHZ3, thereby regulating its transcriptional repressor activity 6. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation (By similarity). Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A 7. In addition to protein deacetylase activity, also acts as a protein-lysine deacylase by recognizing other acyl groups: catalyzes removal of (2E)-butenoyl (crotonyl) and 2-hydroxyisobutanoyl (2-hydroxyisobutyryl) acyl groups from lysine residues, leading to protein decrotonylation and de-2-hydroxyisobutyrylation, respectively 8,9....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Chromatin regulator, Hydrolase, Repressor
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
This gene product belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes, and are responsible for the deacetylation of lysine residues at the N-terminal regions of core histones (H2A, H2B, H3 and H4). This protein forms transcriptional repressor complexes by associating with many different proteins, including YY1, a mammalian zinc-finger transcription factor. Thus, it plays an important role in transcriptional regulation, cell cycle progression and developmental events. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0000118[histone deacetylase complex] GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000781[chromosome, telomeric region] GO:0000785[chromatin] GO:0003682[chromatin binding] GO:0003723[RNA binding] GO:0004407[histone deacetylase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006325[chromatin organization] GO:0006338[chromatin remodeling] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008284[positive regulation of cell population proliferation] GO:0009913[epidermal cell differentiation] GO:0010977[negative regulation of neuron projection development] GO:0016358[dendrite development] GO:0016575[histone deacetylation] GO:0016580[Sin3 complex] GO:0016581[NuRD complex] GO:0016787[hydrolase activity] GO:0019213[deacetylase activity] GO:0019899[enzyme binding] GO:0030336[negative regulation of cell migration] GO:0030512[negative regulation of transforming growth factor beta receptor signaling pathway] GO:0031492[nucleosomal DNA binding] GO:0032922[circadian regulation of gene expression] GO:0032967[positive regulation of collagen biosynthetic process] GO:0032991[protein-containing complex] GO:0033558[protein lysine deacetylase activity] GO:0035098[ESC/E(Z) complex] GO:0042475[odontogenesis of dentin-containing tooth] GO:0042659[regulation of cell fate specification] GO:0042733[embryonic digit morphogenesis] GO:0042826[histone deacetylase binding] GO:0043066[negative regulation of apoptotic process] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0043565[sequence-specific DNA binding] GO:0045347[negative regulation of MHC class II biosynthetic process] GO:0045862[positive regulation of proteolysis] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048511[rhythmic process] GO:0051059[NF-kappaB binding] GO:0060789[hair follicle placode formation] GO:0061029[eyelid development in camera-type eye] GO:0061198[fungiform papilla formation] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070828[heterochromatin organization] GO:0070932[histone H3 deacetylation] GO:0070933[histone H4 deacetylation] GO:0160008[protein decrotonylase activity] GO:0160009[histone decrotonylase activity] GO:0160010[protein de-2-hydroxyisobutyrylase activity] GO:1902455[negative regulation of stem cell population maintenance] GO:1902459[positive regulation of stem cell population maintenance] GO:2000273[positive regulation of signaling receptor activity] GO:2000736[regulation of stem cell differentiation]
SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000118[histone deacetylase complex] GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000781[chromosome, telomeric region] GO:0000785[chromatin] GO:0001975[response to amphetamine] GO:0003300[cardiac muscle hypertrophy] GO:0003682[chromatin binding] GO:0003723[RNA binding] GO:0004407[histone deacetylase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006325[chromatin organization] GO:0006338[chromatin remodeling] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008284[positive regulation of cell population proliferation] GO:0009410[response to xenobiotic stimulus] GO:0009913[epidermal cell differentiation] GO:0010718[positive regulation of epithelial to mesenchymal transition] GO:0010977[negative regulation of neuron projection development] GO:0016358[dendrite development] GO:0016575[histone deacetylation] GO:0016580[Sin3 complex] GO:0016581[NuRD complex] GO:0016787[hydrolase activity] GO:0019213[deacetylase activity] GO:0019899[enzyme binding] GO:0030336[negative regulation of cell migration] GO:0030512[negative regulation of transforming growth factor beta receptor signaling pathway] GO:0031000[response to caffeine] GO:0031072[heat shock protein binding] GO:0031492[nucleosomal DNA binding] GO:0032496[response to lipopolysaccharide] GO:0032732[positive regulation of interleukin-1 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0032922[circadian regulation of gene expression] GO:0032967[positive regulation of collagen biosynthetic process] GO:0032991[protein-containing complex] GO:0033558[protein lysine deacetylase activity] GO:0034605[cellular response to heat] GO:0035094[response to nicotine] GO:0035098[ESC/E(Z) complex] GO:0042220[response to cocaine] GO:0042475[odontogenesis of dentin-containing tooth] GO:0042531[positive regulation of tyrosine phosphorylation of STAT protein] GO:0042659[regulation of cell fate specification] GO:0042733[embryonic digit morphogenesis] GO:0042826[histone deacetylase binding] GO:0043066[negative regulation of apoptotic process] GO:0043392[negative regulation of DNA binding] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0043565[sequence-specific DNA binding] GO:0045347[negative regulation of MHC class II biosynthetic process] GO:0045862[positive regulation of proteolysis] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048149[behavioral response to ethanol] GO:0048511[rhythmic process] GO:0048714[positive regulation of oligodendrocyte differentiation] GO:0051059[NF-kappaB binding] GO:0055093[response to hyperoxia] GO:0060789[hair follicle placode formation] GO:0061000[negative regulation of dendritic spine development] GO:0061029[eyelid development in camera-type eye] GO:0061198[fungiform papilla formation] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070301[cellular response to hydrogen peroxide] GO:0070828[heterochromatin organization] GO:0070932[histone H3 deacetylation] GO:0070933[histone H4 deacetylation] GO:0071300[cellular response to retinoic acid] GO:0071560[cellular response to transforming growth factor beta stimulus] GO:0160008[protein decrotonylase activity] GO:0160009[histone decrotonylase activity] GO:0160010[protein de-2-hydroxyisobutyrylase activity] GO:1902437[positive regulation of male mating behavior] GO:1902455[negative regulation of stem cell population maintenance] GO:1902459[positive regulation of stem cell population maintenance] GO:1903351[cellular response to dopamine] GO:1990841[promoter-specific chromatin binding] GO:2000273[positive regulation of signaling receptor activity] GO:2000736[regulation of stem cell differentiation] GO:2000757[negative regulation of peptidyl-lysine acetylation]
Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Small molecule drugs Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000118[histone deacetylase complex] GO:0000122[negative regulation of transcription by RNA polymerase II] GO:0000781[chromosome, telomeric region] GO:0000785[chromatin] GO:0003682[chromatin binding] GO:0003723[RNA binding] GO:0004407[histone deacetylase activity] GO:0005515[protein binding] GO:0005634[nucleus] GO:0005654[nucleoplasm] GO:0005737[cytoplasm] GO:0006325[chromatin organization] GO:0006338[chromatin remodeling] GO:0006357[regulation of transcription by RNA polymerase II] GO:0008284[positive regulation of cell population proliferation] GO:0009913[epidermal cell differentiation] GO:0010977[negative regulation of neuron projection development] GO:0016358[dendrite development] GO:0016575[histone deacetylation] GO:0016580[Sin3 complex] GO:0016581[NuRD complex] GO:0016787[hydrolase activity] GO:0019213[deacetylase activity] GO:0019899[enzyme binding] GO:0030336[negative regulation of cell migration] GO:0030512[negative regulation of transforming growth factor beta receptor signaling pathway] GO:0031492[nucleosomal DNA binding] GO:0032922[circadian regulation of gene expression] GO:0032967[positive regulation of collagen biosynthetic process] GO:0032991[protein-containing complex] GO:0033558[protein lysine deacetylase activity] GO:0035098[ESC/E(Z) complex] GO:0042475[odontogenesis of dentin-containing tooth] GO:0042659[regulation of cell fate specification] GO:0042733[embryonic digit morphogenesis] GO:0042826[histone deacetylase binding] GO:0043066[negative regulation of apoptotic process] GO:0043433[negative regulation of DNA-binding transcription factor activity] GO:0043565[sequence-specific DNA binding] GO:0045347[negative regulation of MHC class II biosynthetic process] GO:0045862[positive regulation of proteolysis] GO:0045892[negative regulation of DNA-templated transcription] GO:0045893[positive regulation of DNA-templated transcription] GO:0045944[positive regulation of transcription by RNA polymerase II] GO:0048511[rhythmic process] GO:0051059[NF-kappaB binding] GO:0060789[hair follicle placode formation] GO:0061029[eyelid development in camera-type eye] GO:0061198[fungiform papilla formation] GO:0061629[RNA polymerase II-specific DNA-binding transcription factor binding] GO:0070828[heterochromatin organization] GO:0070932[histone H3 deacetylation] GO:0070933[histone H4 deacetylation] GO:0160008[protein decrotonylase activity] GO:0160009[histone decrotonylase activity] GO:0160010[protein de-2-hydroxyisobutyrylase activity] GO:1902455[negative regulation of stem cell population maintenance] GO:1902459[positive regulation of stem cell population maintenance] GO:2000273[positive regulation of signaling receptor activity] GO:2000736[regulation of stem cell differentiation]
Phobius predicted membrane proteins TMHMM predicted membrane proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
