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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Enzymes Human disease related genes
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
9
Cytoband
q21.33
Chromosome location (bp)
87497228 - 87708634
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Apoptosis, Translation regulation
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
ATP-binding, GTP-binding, Nucleotide-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
P53355 [Direct mapping] Death-associated protein kinase 1
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Enzymes ENZYME proteins Transferases Kinases CAMK Ser/Thr protein kinases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers Human disease related genes Cancers Cancers of the urinary system Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000166[nucleotide binding] GO:0002357[defense response to tumor cell] GO:0002834[regulation of response to tumor cell] GO:0004672[protein kinase activity] GO:0004674[protein serine/threonine kinase activity] GO:0004683[calmodulin-dependent protein kinase activity] GO:0005515[protein binding] GO:0005516[calmodulin binding] GO:0005524[ATP binding] GO:0005525[GTP binding] GO:0005634[nucleus] GO:0005737[cytoplasm] GO:0005856[cytoskeleton] GO:0005886[plasma membrane] GO:0006417[regulation of translation] GO:0006468[protein phosphorylation] GO:0006915[apoptotic process] GO:0007165[signal transduction] GO:0008625[extrinsic apoptotic signaling pathway via death domain receptors] GO:0010468[regulation of gene expression] GO:0010506[regulation of autophagy] GO:0010508[positive regulation of autophagy] GO:0010556[regulation of macromolecule biosynthetic process] GO:0014069[postsynaptic density] GO:0015629[actin cytoskeleton] GO:0016301[kinase activity] GO:0016310[phosphorylation] GO:0016740[transferase activity] GO:0017075[syntaxin-1 binding] GO:0017148[negative regulation of translation] GO:0031326[regulation of cellular biosynthetic process] GO:0035556[intracellular signal transduction] GO:0042802[identical protein binding] GO:0042981[regulation of apoptotic process] GO:0043065[positive regulation of apoptotic process] GO:0043066[negative regulation of apoptotic process] GO:0043280[positive regulation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0044093[positive regulation of molecular function] GO:0045087[innate immune response] GO:0046777[protein autophosphorylation] GO:0048583[regulation of response to stimulus] GO:0071345[cellular response to cytokine stimulus] GO:0071346[cellular response to interferon-gamma] GO:0071447[cellular response to hydroperoxide] GO:0097190[apoptotic signaling pathway] GO:0098978[glutamatergic synapse] GO:0106310[protein serine kinase activity] GO:1904094[positive regulation of autophagic cell death] GO:1990722[DAPK1-calmodulin complex] GO:2000310[regulation of NMDA receptor activity]
The Human Protein Atlas project is funded
