GENERAL INFORMATIONi
Gene namei SRC
Synonyms ASV, c-src, SRC1
Gene descriptioni SRC proto-oncogene, non-receptor tyrosine kinase
Protein classi Cancer-related genes
Disease related genes
Enzymes
FDA approved drug targets
Human disease related genes
Plasma proteins
Transporters
Predicted locationi Intracellular
Protein evidence Evidence at protein level (all genes)
GENE INFORMATIONi
Chromosome 20
Cytoband q11.23
Chromosome location (bp) 37344685 - 37406050
Number of transcriptsi 7
Ensembl ENSG00000197122 (version 109)
Entrez gene 6714
HGNC HGNC:11283
UniProt P12931 (UniProt - Evidence at protein level)
neXtProt NX_P12931
GeneCards SRC
Antibodypedia SRC antibodies


PROTEIN FUNCTION
Protein function (UniProt)i Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy between members of the SRC kinase family, identification of the specific role of each SRC kinase is very difficult. SRC appears to be one of the primary kinases activated following engagement of receptors and plays a role in the activation of other protein tyrosine kinase (PTK) families. Receptor clustering or dimerization leads to recruitment of SRC to the receptor complexes where it phosphorylates the tyrosine residues within the receptor cytoplasmic domains. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1. Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1 and to localize to actin filaments. Cytoskeletal reorganization is also controlled through the phosphorylation of cortactin (CTTN) (Probable). When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN) 1. In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP). Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1 (Probable). Phosphorylates PKP3 at 'Tyr-195' in response to reactive oxygen species, which may cause the release of PKP3 from desmosome cell junctions into the cytoplasm 2. Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors (By similarity). Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1 3. Plays a role in EGF-mediated calcium-activated chloride channel activation 4. Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization. Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor (Probable). Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus 5. Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function 6, 7. Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase 8. Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation 9. Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731' 10, 11. Enhances RIGI-elicited antiviral signaling 12. Phosphorylates PDPK1 at 'Tyr-9', 'Tyr-373' and 'Tyr-376' 13. Phosphorylates BCAR1 at 'Tyr-128' 14. Phosphorylates CBLC at multiple tyrosine residues, phosphorylation at 'Tyr-341' activates CBLC E3 activity 15. Phosphorylates synaptic vesicle protein synaptophysin (SYP) (By similarity). Involved in anchorage-independent cell growth 16. Required for podosome formation (By similarity). Mediates IL6 signaling by activating YAP1-NOTCH pathway to induce inflammation-induced epithelial regeneration 17. Phosphorylates OTUB1, promoting deubiquitination of RPTOR 18. Phosphorylates caspase CASP8 at 'Tyr-380' which negatively regulates CASP8 processing and activation, down-regulating CASP8 proapoptotic function 19. show less
Molecular function (UniProt)i Kinase, Transferase, Tyrosine-protein kinase
Biological process (UniProt)i Cell adhesion, Cell cycle, Host-virus interaction, Immunity
Ligand (UniProt)i ATP-binding, Nucleotide-binding
Gene summary (Entrez)i This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] show less
PROTEIN INFORMATIONi
Splice variant SwissProt TrEMBL Protein class Gene ontology Length & mass Signal peptide
(predicted)		 Transmembrane regions
(predicted)
SRC-201
ENSP00000350941
ENST00000358208
P12931
[Direct mapping] Proto-oncogene tyrosine-protein kinase Src
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Transporters
   Accessory Factors Involved in Transport
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Cardiovascular diseases
   Hematologic diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002376 [immune system process]
GO:0002862 [negative regulation of inflammatory response to antigenic stimulus]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005764 [lysosome]
GO:0005770 [late endosome]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008022 [protein C-terminus binding]
GO:0010632 [regulation of epithelial cell migration]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016004 [phospholipase activator activity]
GO:0016020 [membrane]
GO:0016236 [macroautophagy]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0020037 [heme binding]
GO:0022407 [regulation of cell-cell adhesion]
GO:0030054 [cell junction]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0031333 [negative regulation of protein-containing complex assembly]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0033625 [positive regulation of integrin activation]
GO:0035306 [positive regulation of dephosphorylation]
GO:0035332 [positive regulation of hippo signaling]
GO:0035556 [intracellular signal transduction]
GO:0035635 [entry of bacterium into host cell]
GO:0036035 [osteoclast development]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038128 [ERBB2 signaling pathway]
GO:0042169 [SH2 domain binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043114 [regulation of vascular permeability]
GO:0043149 [stress fiber assembly]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043274 [phospholipase binding]
GO:0044325 [transmembrane transporter binding]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045124 [regulation of bone resorption]
GO:0045296 [cadherin binding]
GO:0045453 [bone resorption]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0046777 [protein autophosphorylation]
GO:0046875 [ephrin receptor binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048041 [focal adhesion assembly]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050847 [progesterone receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051057 [positive regulation of small GTPase mediated signal transduction]
GO:0051117 [ATPase binding]
GO:0051219 [phosphoprotein binding]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051902 [negative regulation of mitochondrial depolarization]
GO:0051974 [negative regulation of telomerase activity]
GO:0060576 [intestinal epithelial cell development]
GO:0070062 [extracellular exosome]
GO:0070102 [interleukin-6-mediated signaling pathway]
GO:0070161 [anchoring junction]
GO:0070555 [response to interleukin-1]
GO:0070700 [BMP receptor binding]
GO:0070851 [growth factor receptor binding]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071393 [cellular response to progesterone stimulus]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0086098 [angiotensin-activated signaling pathway involved in heart process]
GO:0097110 [scaffold protein binding]
GO:1903997 [positive regulation of non-membrane spanning protein tyrosine kinase activity]
GO:2000394 [positive regulation of lamellipodium morphogenesis]
GO:2000641 [regulation of early endosome to late endosome transport]
GO:2000811 [negative regulation of anoikis]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
GO:2001286 [regulation of caveolin-mediated endocytosis]
Show all
 553 aa
62.1 kDa 		No 0
SRC-202
ENSP00000362659
ENST00000373558
P12931
[Direct mapping] Proto-oncogene tyrosine-protein kinase Src
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Transporters
   Accessory Factors Involved in Transport
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Cardiovascular diseases
   Hematologic diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002376 [immune system process]
GO:0002862 [negative regulation of inflammatory response to antigenic stimulus]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005764 [lysosome]
GO:0005770 [late endosome]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008022 [protein C-terminus binding]
GO:0010632 [regulation of epithelial cell migration]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016004 [phospholipase activator activity]
GO:0016020 [membrane]
GO:0016236 [macroautophagy]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0020037 [heme binding]
GO:0022407 [regulation of cell-cell adhesion]
GO:0030054 [cell junction]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0031333 [negative regulation of protein-containing complex assembly]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0033625 [positive regulation of integrin activation]
GO:0035306 [positive regulation of dephosphorylation]
GO:0035332 [positive regulation of hippo signaling]
GO:0035556 [intracellular signal transduction]
GO:0035635 [entry of bacterium into host cell]
GO:0036035 [osteoclast development]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038128 [ERBB2 signaling pathway]
GO:0042169 [SH2 domain binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043114 [regulation of vascular permeability]
GO:0043149 [stress fiber assembly]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043274 [phospholipase binding]
GO:0044325 [transmembrane transporter binding]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045124 [regulation of bone resorption]
GO:0045296 [cadherin binding]
GO:0045453 [bone resorption]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0046777 [protein autophosphorylation]
GO:0046875 [ephrin receptor binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048041 [focal adhesion assembly]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050847 [progesterone receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051057 [positive regulation of small GTPase mediated signal transduction]
GO:0051117 [ATPase binding]
GO:0051219 [phosphoprotein binding]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051902 [negative regulation of mitochondrial depolarization]
GO:0051974 [negative regulation of telomerase activity]
GO:0060576 [intestinal epithelial cell development]
GO:0070062 [extracellular exosome]
GO:0070102 [interleukin-6-mediated signaling pathway]
GO:0070161 [anchoring junction]
GO:0070555 [response to interleukin-1]
GO:0070700 [BMP receptor binding]
GO:0070851 [growth factor receptor binding]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071393 [cellular response to progesterone stimulus]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0086098 [angiotensin-activated signaling pathway involved in heart process]
GO:0097110 [scaffold protein binding]
GO:1903997 [positive regulation of non-membrane spanning protein tyrosine kinase activity]
GO:2000394 [positive regulation of lamellipodium morphogenesis]
GO:2000641 [regulation of early endosome to late endosome transport]
GO:2000811 [negative regulation of anoikis]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
GO:2001286 [regulation of caveolin-mediated endocytosis]
Show all
 542 aa
60.6 kDa 		No 0
SRC-203
ENSP00000362668
ENST00000373567
P12931
[Direct mapping] Proto-oncogene tyrosine-protein kinase Src
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Transporters
   Accessory Factors Involved in Transport
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Cardiovascular diseases
   Hematologic diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002376 [immune system process]
GO:0002862 [negative regulation of inflammatory response to antigenic stimulus]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005764 [lysosome]
GO:0005770 [late endosome]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008022 [protein C-terminus binding]
GO:0010632 [regulation of epithelial cell migration]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016004 [phospholipase activator activity]
GO:0016020 [membrane]
GO:0016236 [macroautophagy]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0020037 [heme binding]
GO:0022407 [regulation of cell-cell adhesion]
GO:0030054 [cell junction]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0031333 [negative regulation of protein-containing complex assembly]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0033625 [positive regulation of integrin activation]
GO:0035306 [positive regulation of dephosphorylation]
GO:0035332 [positive regulation of hippo signaling]
GO:0035556 [intracellular signal transduction]
GO:0035635 [entry of bacterium into host cell]
GO:0036035 [osteoclast development]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038128 [ERBB2 signaling pathway]
GO:0042169 [SH2 domain binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043114 [regulation of vascular permeability]
GO:0043149 [stress fiber assembly]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043274 [phospholipase binding]
GO:0044325 [transmembrane transporter binding]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045124 [regulation of bone resorption]
GO:0045296 [cadherin binding]
GO:0045453 [bone resorption]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0046777 [protein autophosphorylation]
GO:0046875 [ephrin receptor binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048041 [focal adhesion assembly]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050847 [progesterone receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051057 [positive regulation of small GTPase mediated signal transduction]
GO:0051117 [ATPase binding]
GO:0051219 [phosphoprotein binding]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051902 [negative regulation of mitochondrial depolarization]
GO:0051974 [negative regulation of telomerase activity]
GO:0060576 [intestinal epithelial cell development]
GO:0070062 [extracellular exosome]
GO:0070102 [interleukin-6-mediated signaling pathway]
GO:0070161 [anchoring junction]
GO:0070555 [response to interleukin-1]
GO:0070700 [BMP receptor binding]
GO:0070851 [growth factor receptor binding]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071393 [cellular response to progesterone stimulus]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0086098 [angiotensin-activated signaling pathway involved in heart process]
GO:0097110 [scaffold protein binding]
GO:1903997 [positive regulation of non-membrane spanning protein tyrosine kinase activity]
GO:2000394 [positive regulation of lamellipodium morphogenesis]
GO:2000641 [regulation of early endosome to late endosome transport]
GO:2000811 [negative regulation of anoikis]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
GO:2001286 [regulation of caveolin-mediated endocytosis]
Show all
 536 aa
59.8 kDa 		No 0
SRC-204
ENSP00000362680
ENST00000373578
P12931
[Direct mapping] Proto-oncogene tyrosine-protein kinase Src
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Transporters
   Accessory Factors Involved in Transport
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Cardiovascular diseases
   Hematologic diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0001545 [primary ovarian follicle growth]
GO:0001819 [positive regulation of cytokine production]
GO:0002102 [podosome]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002376 [immune system process]
GO:0002862 [negative regulation of inflammatory response to antigenic stimulus]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005080 [protein kinase C binding]
GO:0005102 [signaling receptor binding]
GO:0005158 [insulin receptor binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005764 [lysosome]
GO:0005770 [late endosome]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005884 [actin filament]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0007283 [spermatogenesis]
GO:0007420 [brain development]
GO:0007611 [learning or memory]
GO:0008022 [protein C-terminus binding]
GO:0008283 [cell population proliferation]
GO:0009410 [response to xenobiotic stimulus]
GO:0009612 [response to mechanical stimulus]
GO:0009615 [response to virus]
GO:0010447 [response to acidic pH]
GO:0010628 [positive regulation of gene expression]
GO:0010632 [regulation of epithelial cell migration]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0010641 [positive regulation of platelet-derived growth factor receptor signaling pathway]
GO:0010907 [positive regulation of glucose metabolic process]
GO:0010954 [positive regulation of protein processing]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0014069 [postsynaptic density]
GO:0014856 [skeletal muscle cell proliferation]
GO:0014911 [positive regulation of smooth muscle cell migration]
GO:0016004 [phospholipase activator activity]
GO:0016020 [membrane]
GO:0016236 [macroautophagy]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016477 [cell migration]
GO:0016740 [transferase activity]
GO:0018105 [peptidyl-serine phosphorylation]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0019901 [protein kinase binding]
GO:0019904 [protein domain specific binding]
GO:0020037 [heme binding]
GO:0022407 [regulation of cell-cell adhesion]
GO:0030054 [cell junction]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0030331 [nuclear estrogen receptor binding]
GO:0030900 [forebrain development]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0031333 [negative regulation of protein-containing complex assembly]
GO:0031648 [protein destabilization]
GO:0031667 [response to nutrient levels]
GO:0031954 [positive regulation of protein autophosphorylation]
GO:0032148 [activation of protein kinase B activity]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0032587 [ruffle membrane]
GO:0032869 [cellular response to insulin stimulus]
GO:0033146 [regulation of intracellular estrogen receptor signaling pathway]
GO:0033625 [positive regulation of integrin activation]
GO:0034332 [adherens junction organization]
GO:0034446 [substrate adhesion-dependent cell spreading]
GO:0034614 [cellular response to reactive oxygen species]
GO:0035306 [positive regulation of dephosphorylation]
GO:0035332 [positive regulation of hippo signaling]
GO:0035556 [intracellular signal transduction]
GO:0035635 [entry of bacterium into host cell]
GO:0036035 [osteoclast development]
GO:0036120 [cellular response to platelet-derived growth factor stimulus]
GO:0038083 [peptidyl-tyrosine autophosphorylation]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038128 [ERBB2 signaling pathway]
GO:0042169 [SH2 domain binding]
GO:0042476 [odontogenesis]
GO:0042542 [response to hydrogen peroxide]
GO:0043005 [neuron projection]
GO:0043025 [neuronal cell body]
GO:0043065 [positive regulation of apoptotic process]
GO:0043066 [negative regulation of apoptotic process]
GO:0043114 [regulation of vascular permeability]
GO:0043149 [stress fiber assembly]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043274 [phospholipase binding]
GO:0043393 [regulation of protein binding]
GO:0043406 [positive regulation of MAP kinase activity]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0044294 [dendritic growth cone]
GO:0044325 [transmembrane transporter binding]
GO:0044877 [protein-containing complex binding]
GO:0045056 [transcytosis]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045124 [regulation of bone resorption]
GO:0045296 [cadherin binding]
GO:0045453 [bone resorption]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0045780 [positive regulation of bone resorption]
GO:0045785 [positive regulation of cell adhesion]
GO:0045892 [negative regulation of DNA-templated transcription]
GO:0045893 [positive regulation of DNA-templated transcription]
GO:0046579 [positive regulation of Ras protein signal transduction]
GO:0046628 [positive regulation of insulin receptor signaling pathway]
GO:0046777 [protein autophosphorylation]
GO:0046875 [ephrin receptor binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048041 [focal adhesion assembly]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048477 [oogenesis]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050839 [cell adhesion molecule binding]
GO:0050847 [progesterone receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051057 [positive regulation of small GTPase mediated signal transduction]
GO:0051117 [ATPase binding]
GO:0051219 [phosphoprotein binding]
GO:0051222 [positive regulation of protein transport]
GO:0051385 [response to mineralocorticoid]
GO:0051450 [myoblast proliferation]
GO:0051602 [response to electrical stimulus]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051902 [negative regulation of mitochondrial depolarization]
GO:0051974 [negative regulation of telomerase activity]
GO:0060065 [uterus development]
GO:0060444 [branching involved in mammary gland duct morphogenesis]
GO:0060491 [regulation of cell projection assembly]
GO:0060576 [intestinal epithelial cell development]
GO:0070062 [extracellular exosome]
GO:0070102 [interleukin-6-mediated signaling pathway]
GO:0070161 [anchoring junction]
GO:0070301 [cellular response to hydrogen peroxide]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0070542 [response to fatty acid]
GO:0070555 [response to interleukin-1]
GO:0070700 [BMP receptor binding]
GO:0070851 [growth factor receptor binding]
GO:0071222 [cellular response to lipopolysaccharide]
GO:0071253 [connexin binding]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071393 [cellular response to progesterone stimulus]
GO:0071398 [cellular response to fatty acid]
GO:0071456 [cellular response to hypoxia]
GO:0071498 [cellular response to fluid shear stress]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:0071803 [positive regulation of podosome assembly]
GO:0071897 [DNA biosynthetic process]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0086098 [angiotensin-activated signaling pathway involved in heart process]
GO:0090263 [positive regulation of canonical Wnt signaling pathway]
GO:0097060 [synaptic membrane]
GO:0097110 [scaffold protein binding]
GO:0098609 [cell-cell adhesion]
GO:0098962 [regulation of postsynaptic neurotransmitter receptor activity]
GO:0098978 [glutamatergic synapse]
GO:0099091 [postsynaptic specialization, intracellular component]
GO:1900182 [positive regulation of protein localization to nucleus]
GO:1902533 [positive regulation of intracellular signal transduction]
GO:1902737 [dendritic filopodium]
GO:1903997 [positive regulation of non-membrane spanning protein tyrosine kinase activity]
GO:1904385 [cellular response to angiotensin]
GO:1904707 [positive regulation of vascular associated smooth muscle cell proliferation]
GO:1990646 [cellular response to prolactin]
GO:2000256 [positive regulation of male germ cell proliferation]
GO:2000386 [positive regulation of ovarian follicle development]
GO:2000394 [positive regulation of lamellipodium morphogenesis]
GO:2000573 [positive regulation of DNA biosynthetic process]
GO:2000588 [positive regulation of platelet-derived growth factor receptor-beta signaling pathway]
GO:2000641 [regulation of early endosome to late endosome transport]
GO:2000811 [negative regulation of anoikis]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
GO:2001286 [regulation of caveolin-mediated endocytosis]
Show all
 536 aa
59.8 kDa 		No 0
SRC-212
ENSP00000508666
ENST00000692112
P12931
[Direct mapping] Proto-oncogene tyrosine-protein kinase Src
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Transporters
   Accessory Factors Involved in Transport
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Cardiovascular diseases
   Hematologic diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002376 [immune system process]
GO:0002862 [negative regulation of inflammatory response to antigenic stimulus]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005764 [lysosome]
GO:0005770 [late endosome]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008022 [protein C-terminus binding]
GO:0010632 [regulation of epithelial cell migration]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016004 [phospholipase activator activity]
GO:0016020 [membrane]
GO:0016236 [macroautophagy]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0020037 [heme binding]
GO:0022407 [regulation of cell-cell adhesion]
GO:0030054 [cell junction]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0031333 [negative regulation of protein-containing complex assembly]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0033625 [positive regulation of integrin activation]
GO:0035306 [positive regulation of dephosphorylation]
GO:0035332 [positive regulation of hippo signaling]
GO:0035556 [intracellular signal transduction]
GO:0035635 [entry of bacterium into host cell]
GO:0036035 [osteoclast development]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038128 [ERBB2 signaling pathway]
GO:0042169 [SH2 domain binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043114 [regulation of vascular permeability]
GO:0043149 [stress fiber assembly]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043274 [phospholipase binding]
GO:0044325 [transmembrane transporter binding]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045124 [regulation of bone resorption]
GO:0045296 [cadherin binding]
GO:0045453 [bone resorption]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0046777 [protein autophosphorylation]
GO:0046875 [ephrin receptor binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048041 [focal adhesion assembly]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050847 [progesterone receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051057 [positive regulation of small GTPase mediated signal transduction]
GO:0051117 [ATPase binding]
GO:0051219 [phosphoprotein binding]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051902 [negative regulation of mitochondrial depolarization]
GO:0051974 [negative regulation of telomerase activity]
GO:0060576 [intestinal epithelial cell development]
GO:0070062 [extracellular exosome]
GO:0070102 [interleukin-6-mediated signaling pathway]
GO:0070161 [anchoring junction]
GO:0070555 [response to interleukin-1]
GO:0070700 [BMP receptor binding]
GO:0070851 [growth factor receptor binding]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071393 [cellular response to progesterone stimulus]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0086098 [angiotensin-activated signaling pathway involved in heart process]
GO:0097110 [scaffold protein binding]
GO:1903997 [positive regulation of non-membrane spanning protein tyrosine kinase activity]
GO:2000394 [positive regulation of lamellipodium morphogenesis]
GO:2000641 [regulation of early endosome to late endosome transport]
GO:2000811 [negative regulation of anoikis]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
GO:2001286 [regulation of caveolin-mediated endocytosis]
Show all
 536 aa
59.8 kDa 		No 0
SRC-213
ENSP00000509325
ENST00000692423
P12931
[Direct mapping] Proto-oncogene tyrosine-protein kinase Src
Show all
Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Transporters
   Accessory Factors Involved in Transport
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Disease related genes
FDA approved drug targets
   Small molecule drugs
Human disease related genes
   Cardiovascular diseases
   Hematologic diseases
Mapped to neXtProt
   neXtProt - Evidence at protein level
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002223 [stimulatory C-type lectin receptor signaling pathway]
GO:0002376 [immune system process]
GO:0002862 [negative regulation of inflammatory response to antigenic stimulus]
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004715 [non-membrane spanning protein tyrosine kinase activity]
GO:0005102 [signaling receptor binding]
GO:0005178 [integrin binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005764 [lysosome]
GO:0005770 [late endosome]
GO:0005829 [cytosol]
GO:0005856 [cytoskeleton]
GO:0005886 [plasma membrane]
GO:0005901 [caveola]
GO:0005925 [focal adhesion]
GO:0006468 [protein phosphorylation]
GO:0007049 [cell cycle]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0007172 [signal complex assembly]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007229 [integrin-mediated signaling pathway]
GO:0008022 [protein C-terminus binding]
GO:0010632 [regulation of epithelial cell migration]
GO:0010634 [positive regulation of epithelial cell migration]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016004 [phospholipase activator activity]
GO:0016020 [membrane]
GO:0016236 [macroautophagy]
GO:0016301 [kinase activity]
GO:0016310 [phosphorylation]
GO:0016740 [transferase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019899 [enzyme binding]
GO:0020037 [heme binding]
GO:0022407 [regulation of cell-cell adhesion]
GO:0030054 [cell junction]
GO:0030154 [cell differentiation]
GO:0030168 [platelet activation]
GO:0031234 [extrinsic component of cytoplasmic side of plasma membrane]
GO:0031295 [T cell costimulation]
GO:0031333 [negative regulation of protein-containing complex assembly]
GO:0032211 [negative regulation of telomere maintenance via telomerase]
GO:0033625 [positive regulation of integrin activation]
GO:0035306 [positive regulation of dephosphorylation]
GO:0035332 [positive regulation of hippo signaling]
GO:0035556 [intracellular signal transduction]
GO:0035635 [entry of bacterium into host cell]
GO:0036035 [osteoclast development]
GO:0038096 [Fc-gamma receptor signaling pathway involved in phagocytosis]
GO:0038128 [ERBB2 signaling pathway]
GO:0042169 [SH2 domain binding]
GO:0043066 [negative regulation of apoptotic process]
GO:0043114 [regulation of vascular permeability]
GO:0043149 [stress fiber assembly]
GO:0043154 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0043274 [phospholipase binding]
GO:0044325 [transmembrane transporter binding]
GO:0045087 [innate immune response]
GO:0045121 [membrane raft]
GO:0045124 [regulation of bone resorption]
GO:0045296 [cadherin binding]
GO:0045453 [bone resorption]
GO:0045747 [positive regulation of Notch signaling pathway]
GO:0046777 [protein autophosphorylation]
GO:0046875 [ephrin receptor binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048013 [ephrin receptor signaling pathway]
GO:0048041 [focal adhesion assembly]
GO:0048471 [perinuclear region of cytoplasm]
GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation]
GO:0050847 [progesterone receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051057 [positive regulation of small GTPase mediated signal transduction]
GO:0051117 [ATPase binding]
GO:0051219 [phosphoprotein binding]
GO:0051895 [negative regulation of focal adhesion assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0051902 [negative regulation of mitochondrial depolarization]
GO:0051974 [negative regulation of telomerase activity]
GO:0060576 [intestinal epithelial cell development]
GO:0070062 [extracellular exosome]
GO:0070102 [interleukin-6-mediated signaling pathway]
GO:0070161 [anchoring junction]
GO:0070555 [response to interleukin-1]
GO:0070700 [BMP receptor binding]
GO:0070851 [growth factor receptor binding]
GO:0071375 [cellular response to peptide hormone stimulus]
GO:0071393 [cellular response to progesterone stimulus]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0086098 [angiotensin-activated signaling pathway involved in heart process]
GO:0097110 [scaffold protein binding]
GO:1903997 [positive regulation of non-membrane spanning protein tyrosine kinase activity]
GO:2000394 [positive regulation of lamellipodium morphogenesis]
GO:2000641 [regulation of early endosome to late endosome transport]
GO:2000811 [negative regulation of anoikis]
GO:2001237 [negative regulation of extrinsic apoptotic signaling pathway]
GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway]
GO:2001286 [regulation of caveolin-mediated endocytosis]
Show all
 536 aa
59.8 kDa 		No 0
SRC-214
ENSP00000510370
ENST00000693012
A0A8I5KYU4
[Direct mapping] Proto-oncogene tyrosine-protein kinase Src
Show all
Predicted intracellular proteins
   Intracellular proteins predicted by MDM and MDSEC
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Nonsense Mutations
   COSMIC Missense Mutations
Human disease related genes
   Cardiovascular diseases
   Hematologic diseases
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 117 aa
12.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.


contact@proteinatlas.org