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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Enzymes Metabolic proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
11
Cytoband
q23.1
Chromosome location (bp)
112175510 - 112224699
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Broad specificity mitochondrial dioxygenase that mediates the asymmetric oxidative cleavage of carotenoids. Cleaves carotenes (pure hydrocarbon carotenoids) such as all-trans-beta-carotene and lycopene as well as xanthophylls (oxygenated carotenoids) such as zeaxanthin, lutein and beta-cryptoxanthin at both the 9,10 and the 9',10' carbon-carbon double bond. Through its function in carotenoids metabolism regulates oxidative stress and the production of important signaling molecules....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Dioxygenase, Oxidoreductase
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Lipid metabolism
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Iron, Metal-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene encodes an enzyme which oxidizes carotenoids such as beta-carotene during the biosynthesis of vitamin A. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
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GO:0003824[catalytic activity] GO:0003834[beta-carotene 15,15'-dioxygenase activity] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0006629[lipid metabolic process] GO:0006720[isoprenoid metabolic process] GO:0010436[carotenoid dioxygenase activity] GO:0010437[9,10 (9', 10')-carotenoid-cleaving dioxygenase activity] GO:0016116[carotenoid metabolic process] GO:0016119[carotene metabolic process] GO:0016121[carotene catabolic process] GO:0016122[xanthophyll metabolic process] GO:0016124[xanthophyll catabolic process] GO:0016491[oxidoreductase activity] GO:0016702[oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0042573[retinoic acid metabolic process] GO:0042574[retinal metabolic process] GO:0046872[metal ion binding] GO:0051213[dioxygenase activity] GO:0051881[regulation of mitochondrial membrane potential] GO:0062172[lutein catabolic process] GO:0102076[beta,beta-carotene-9',10'-cleaving oxygenase activity] GO:1901176[lycopene catabolic process] GO:1901826[zeaxanthin catabolic process] GO:2000377[regulation of reactive oxygen species metabolic process]
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824[catalytic activity] GO:0003834[beta-carotene 15,15'-dioxygenase activity] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0006629[lipid metabolic process] GO:0006720[isoprenoid metabolic process] GO:0010436[carotenoid dioxygenase activity] GO:0010437[9,10 (9', 10')-carotenoid-cleaving dioxygenase activity] GO:0016116[carotenoid metabolic process] GO:0016119[carotene metabolic process] GO:0016121[carotene catabolic process] GO:0016124[xanthophyll catabolic process] GO:0016491[oxidoreductase activity] GO:0016702[oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0042573[retinoic acid metabolic process] GO:0042574[retinal metabolic process] GO:0046872[metal ion binding] GO:0051213[dioxygenase activity] GO:0051881[regulation of mitochondrial membrane potential] GO:0062172[lutein catabolic process] GO:0102076[beta,beta-carotene-9',10'-cleaving oxygenase activity] GO:1901176[lycopene catabolic process] GO:1901826[zeaxanthin catabolic process] GO:2000377[regulation of reactive oxygen species metabolic process]
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824[catalytic activity] GO:0003834[beta-carotene 15,15'-dioxygenase activity] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0006629[lipid metabolic process] GO:0006720[isoprenoid metabolic process] GO:0010436[carotenoid dioxygenase activity] GO:0010437[9,10 (9', 10')-carotenoid-cleaving dioxygenase activity] GO:0016116[carotenoid metabolic process] GO:0016119[carotene metabolic process] GO:0016121[carotene catabolic process] GO:0016124[xanthophyll catabolic process] GO:0016491[oxidoreductase activity] GO:0016702[oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0042573[retinoic acid metabolic process] GO:0042574[retinal metabolic process] GO:0046872[metal ion binding] GO:0051213[dioxygenase activity] GO:0051881[regulation of mitochondrial membrane potential] GO:0062172[lutein catabolic process] GO:0102076[beta,beta-carotene-9',10'-cleaving oxygenase activity] GO:1901176[lycopene catabolic process] GO:1901826[zeaxanthin catabolic process] GO:2000377[regulation of reactive oxygen species metabolic process]
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824[catalytic activity] GO:0003834[beta-carotene 15,15'-dioxygenase activity] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0006629[lipid metabolic process] GO:0006720[isoprenoid metabolic process] GO:0010436[carotenoid dioxygenase activity] GO:0010437[9,10 (9', 10')-carotenoid-cleaving dioxygenase activity] GO:0016116[carotenoid metabolic process] GO:0016119[carotene metabolic process] GO:0016121[carotene catabolic process] GO:0016124[xanthophyll catabolic process] GO:0016491[oxidoreductase activity] GO:0016702[oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0042573[retinoic acid metabolic process] GO:0042574[retinal metabolic process] GO:0046872[metal ion binding] GO:0051213[dioxygenase activity] GO:0051881[regulation of mitochondrial membrane potential] GO:0062172[lutein catabolic process] GO:0102076[beta,beta-carotene-9',10'-cleaving oxygenase activity] GO:1901176[lycopene catabolic process] GO:1901826[zeaxanthin catabolic process] GO:2000377[regulation of reactive oxygen species metabolic process]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824[catalytic activity] GO:0006629[lipid metabolic process] GO:0006720[isoprenoid metabolic process] GO:0016702[oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0046872[metal ion binding]
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824[catalytic activity] GO:0003834[beta-carotene 15,15'-dioxygenase activity] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0006629[lipid metabolic process] GO:0006720[isoprenoid metabolic process] GO:0010436[carotenoid dioxygenase activity] GO:0010437[9,10 (9', 10')-carotenoid-cleaving dioxygenase activity] GO:0016116[carotenoid metabolic process] GO:0016119[carotene metabolic process] GO:0016121[carotene catabolic process] GO:0016124[xanthophyll catabolic process] GO:0016491[oxidoreductase activity] GO:0016702[oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0042573[retinoic acid metabolic process] GO:0042574[retinal metabolic process] GO:0046872[metal ion binding] GO:0051213[dioxygenase activity] GO:0051881[regulation of mitochondrial membrane potential] GO:0062172[lutein catabolic process] GO:0102076[beta,beta-carotene-9',10'-cleaving oxygenase activity] GO:1901176[lycopene catabolic process] GO:1901826[zeaxanthin catabolic process] GO:2000377[regulation of reactive oxygen species metabolic process]
Enzymes ENZYME proteins Oxidoreductases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824[catalytic activity] GO:0003834[beta-carotene 15,15'-dioxygenase activity] GO:0005739[mitochondrion] GO:0005759[mitochondrial matrix] GO:0006629[lipid metabolic process] GO:0006720[isoprenoid metabolic process] GO:0010436[carotenoid dioxygenase activity] GO:0010437[9,10 (9', 10')-carotenoid-cleaving dioxygenase activity] GO:0016116[carotenoid metabolic process] GO:0016119[carotene metabolic process] GO:0016121[carotene catabolic process] GO:0016124[xanthophyll catabolic process] GO:0016491[oxidoreductase activity] GO:0016702[oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0042573[retinoic acid metabolic process] GO:0042574[retinal metabolic process] GO:0046872[metal ion binding] GO:0051213[dioxygenase activity] GO:0051881[regulation of mitochondrial membrane potential] GO:0062172[lutein catabolic process] GO:0102076[beta,beta-carotene-9',10'-cleaving oxygenase activity] GO:1901176[lycopene catabolic process] GO:1901826[zeaxanthin catabolic process] GO:2000377[regulation of reactive oxygen species metabolic process]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824[catalytic activity] GO:0006629[lipid metabolic process] GO:0006720[isoprenoid metabolic process] GO:0016702[oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen] GO:0046872[metal ion binding]
The Human Protein Atlas project is funded
