Expression of RPL37A in urothelial cancer

BLADDER UROTHELIAL CARCINOMA (TCGA) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

RPL37A is not prognostic in Bladder Urothelial Carcinoma (TCGA)

Stage:

Survival analysis

Current cut offⁱ :

Best expression cut offⁱ : 2282.66

Median expressionⁱ : N/A

Median follow up timeⁱ : N/A

P scoreⁱ N/A

5-year survival highⁱ N/A

5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average pTPM

2724.2

Number of samples

169

Samples

Sample	Description	pTPM
TCGA-ZF-A9RN-01A	67 years, female, white, stage:Stage III, dead, 615 days	7662.1
TCGA-BT-A0S7-01A	75 years, male, white, stage:Stage III, dead, 200 days	6714.3
TCGA-DK-AA75-01A	82 years, male, white, stage:Stage III, dead, 340 days	6382.5
TCGA-ZF-AA5N-01A	62 years, female, white, stage:Stage IV, dead, 168 days	6101.4
TCGA-XF-AAMH-01A	80 years, male, white, stage:Stage IV, dead, 344 days	5938.1
TCGA-CF-A47T-01A	58 years, female, asian, stage:Stage II, dead, 385 days	5792.1
TCGA-XF-AAN8-01A	74 years, female, white, stage:Stage III, dead, 118 days	5551.5
TCGA-DK-AA6W-01A	78 years, male, white, stage:Stage II, dead, 415 days	5462.7
TCGA-XF-A8HF-01A	80 years, male, white, stage:Stage III, dead, 2954 days	5295.6
TCGA-FJ-A3ZE-01A	65 years, male, white, stage:Stage IV, dead, 324 days	4954.0
TCGA-ZF-A9RD-01A	75 years, female, white, stage:Stage IV, dead, 408 days	4855.2
TCGA-FJ-A871-01A	49 years, male, white, stage:Stage III, dead, 272 days	4786.3
TCGA-XF-A9T2-01A	54 years, male, white, stage:Stage III, dead, 575 days	4735.0
TCGA-G2-A2ES-01A	85 years, male, white, stage:Stage II, dead, 1004 days	4678.1
TCGA-ZF-AA4N-01A	74 years, male, white, stage:Stage II, dead, 88 days	4616.4
TCGA-K4-A5RI-01A	67 years, female, white, stage:Stage III, dead, 356 days	4599.6
TCGA-G2-A2EC-01A	58 years, female, black or african american, stage:Stage II, dead, 696 days	4354.8
TCGA-UY-A78M-01A	81 years, female, asian, stage:Stage IV, dead, 690 days	4317.7
TCGA-XF-A9SH-01A	65 years, female, asian, stage:Stage II, dead, 1971 days	4241.0
TCGA-C4-A0F7-01A	77 years, male, stage:Stage IV, dead, 62 days	4235.4
TCGA-FD-A5BX-01A	82 years, male, white, stage:Stage IV, dead, 173 days	4226.8
TCGA-GC-A3BM-01A	70 years, male, white, stage:Stage II, dead, 651 days	4175.7
TCGA-GU-A42Q-01A	67 years, male, white, stage:Stage III, dead, 344 days	4159.8
TCGA-UY-A78N-01A	80 years, male, white, stage:Stage IV, dead, 2641 days	4154.6
TCGA-CU-A0YO-01A	84 years, male, white, stage:Stage IV, dead, 149 days	4148.2
TCGA-ZF-AA4U-01A	70 years, male, white, stage:Stage III, dead, 262 days	3925.5
TCGA-FD-A62O-01A	74 years, male, white, stage:Stage IV, dead, 216 days	3847.8
TCGA-BT-A20N-01A	72 years, male, stage:Stage III, dead, 795 days	3829.6
TCGA-5N-A9KM-01A	73 years, female, white, stage:Stage III, dead, 530 days	3804.5
TCGA-DK-AA6Q-01A	61 years, female, white, stage:Stage IV, dead, 413 days	3697.5
TCGA-BT-A20W-01A	71 years, male, white, stage:Stage II, dead, 254 days	3688.2
TCGA-G2-A2EO-01A	69 years, male, white, stage:Stage III, dead, 1804 days	3676.6
TCGA-XF-AAN1-01A	75 years, female, stage:Stage III, dead, 941 days	3669.5
TCGA-ZF-AA54-01A	71 years, male, white, stage:Stage III, dead, 590 days	3604.6
TCGA-DK-A1A3-01A	60 years, male, white, stage:Stage IV, dead, 665 days	3557.4
TCGA-GU-AATQ-01A	68 years, male, white, stage:Stage III, dead, 213 days	3517.1
TCGA-DK-A3IQ-01A	74 years, male, white, stage:Stage III, dead, 539 days	3449.4
TCGA-DK-A1AB-01A	74 years, female, white, stage:Stage IV, dead, 508 days	3413.9
TCGA-YC-A9TC-01A	71 years, male, white, stage:Stage IV, dead, 20 days	3334.3
TCGA-FD-A3B4-01A	55 years, female, black or african american, stage:Stage III, dead, 510 days	3330.6
TCGA-FD-A6TF-01A	80 years, female, white, stage:Stage IV, dead, 69 days	3320.9
TCGA-4Z-AA7N-01A	65 years, male, white, stage:Stage III, dead, 1367 days	3310.3
TCGA-CU-A72E-01A	76 years, male, white, stage:Stage IV, dead, 413 days	3290.3
TCGA-FD-A3B6-01A	75 years, male, white, stage:Stage II, dead, 1005 days	3286.0
TCGA-FD-A6TH-01A	63 years, male, white, stage:Stage IV, dead, 131 days	3274.8
TCGA-DK-A2I2-01A	63 years, female, white, stage:Stage IV, dead, 237 days	3271.0
TCGA-FD-A6TD-01A	77 years, male, white, stage:Stage III, dead, 386 days	3265.1
TCGA-XF-AAML-01A	75 years, male, white, stage:Stage II, dead, 232 days	3255.3
TCGA-XF-A9SZ-01A	79 years, male, white, stage:Stage IV, dead, 859 days	3242.2
TCGA-GU-A762-01A	87 years, male, white, stage:Stage IV, dead, 232 days	3221.1
TCGA-BT-A20J-01A	75 years, male, white, stage:Stage II, dead, 579 days	3189.7
TCGA-BT-A2LD-01A	78 years, female, white, stage:Stage IV, dead, 623 days	3185.9
TCGA-UY-A78K-01A	60 years, male, white, stage:Stage IV, dead, 536 days	3141.3
TCGA-XF-AAMZ-01A	81 years, female, white, stage:Stage IV, dead, 1348 days	3138.7
TCGA-XF-A8HI-01A	57 years, female, white, stage:Stage IV, dead, 544 days	3119.2
TCGA-E7-A4XJ-01A	66 years, male, asian, stage:Stage II, dead, 68 days	3058.8
TCGA-BT-A2LB-01A	73 years, female, white, stage:Stage III, dead, 492 days	3042.5
TCGA-XF-AAMT-01A	75 years, female, white, stage:Stage IV, dead, 90 days	3031.4
TCGA-FD-A43Y-01A	65 years, male, white, stage:Stage III, dead, 474 days	2989.0
TCGA-G2-A3IB-01A	66 years, male, black or african american, stage:Stage II, dead, 220 days	2988.5
TCGA-G2-A3IE-01A	51 years, male, white, stage:Stage II, dead, 612 days	2937.2
TCGA-ZF-AA56-01A	79 years, female, white, stage:Stage III, dead, 259 days	2891.9
TCGA-XF-A9ST-01A	68 years, male, white, stage:Stage III, dead, 128 days	2871.3
TCGA-FD-A5BT-01A	84 years, male, white, stage:Stage III, dead, 328 days	2849.2
TCGA-4Z-AA7Q-01A	79 years, male, white, stage:Stage III, dead, 510 days	2834.2
TCGA-2F-A9KR-01A	59 years, female, stage:Stage III, dead, 3183 days	2782.4
TCGA-CF-A9FL-01A	85 years, male, asian, stage:Stage III, dead, 565 days	2779.1
TCGA-XF-AAN7-01A	60 years, male, white, stage:Stage IV, dead, 565 days	2766.3
TCGA-BT-A20X-01A	56 years, male, white, stage:Stage IV, dead, 251 days	2743.1
TCGA-DK-A3IN-01A	72 years, male, white, stage:Stage III, dead, 250 days	2724.2
TCGA-XF-AAN0-01A	68 years, male, white, stage:Stage IV, dead, 1718 days	2719.4
TCGA-BT-A20U-01A	70 years, female, white, stage:Stage III, dead, 455 days	2716.0
TCGA-S5-A6DX-01A	83 years, male, white, stage:Stage IV, dead, 56 days	2701.8
TCGA-2F-A9KO-01A	63 years, male, white, stage:Stage IV, dead, 734 days	2696.1
TCGA-BT-A20V-01A	59 years, female, black or african american, stage:Stage IV, dead, 154 days	2673.1
TCGA-FD-A3B7-01A	66 years, male, black or african american, stage:Stage III, dead, 122 days	2655.1
TCGA-XF-A9SP-01A	59 years, male, white, stage:Stage III, dead, 454 days	2654.8
TCGA-C4-A0EZ-01A	69 years, female, stage:Stage IV, dead, 273 days	2639.5
TCGA-FD-A3B5-01A	86 years, male, black or african american, stage:Stage IV, dead, 272 days	2631.6
TCGA-FD-A3SQ-01A	62 years, male, white, stage:Stage IV, dead, 1423 days	2619.1
TCGA-2F-A9KP-01A	66 years, male, white, stage:Stage IV, dead, 364 days	2560.4
TCGA-DK-A3IU-01A	58 years, male, white, stage:Stage II, dead, 706 days	2542.7
TCGA-4Z-AA82-01A	59 years, male, black or african american, stage:Stage IV, dead, 1556 days	2496.6
TCGA-4Z-AA81-01A	80 years, male, white, stage:Stage II, dead, 1270 days	2482.4
TCGA-GU-A767-01A	81 years, male, white, stage:Stage IV, dead, 144 days	2479.8
TCGA-FJ-A3Z9-01A	72 years, male, white, stage:'--, dead, 385 days	2478.0
TCGA-BT-A3PK-01A	80 years, male, white, stage:Stage II, dead, 303 days	2464.0
TCGA-ZF-AA52-01A	70 years, male, white, stage:Stage III, dead, 1077 days	2455.0
TCGA-BL-A13J-01A	65 years, male, white, stage:Stage IV, dead, 81 days	2422.6
TCGA-GU-A42R-01A	68 years, male, white, stage:Stage IV, dead, 577 days	2360.7
TCGA-FD-A3B3-01A	74 years, female, white, stage:Stage III, dead, 974 days	2356.3
TCGA-XF-A9SL-01A	69 years, male, white, stage:Stage IV, dead, 2020 days	2353.2
TCGA-GV-A3JV-01A	66 years, male, white, stage:Stage IV, dead, 434 days	2350.9
TCGA-ZF-A9R0-01A	82 years, male, white, stage:Stage III, dead, 680 days	2325.2
TCGA-E7-A97P-01A	73 years, male, asian, stage:Stage II, dead, 437 days	2310.5
TCGA-GV-A3QF-01A	79 years, male, white, stage:Stage IV, dead, 617 days	2282.7
TCGA-XF-A9SU-01A	74 years, female, white, stage:Stage IV, dead, 182 days	2251.4
TCGA-BT-A0YX-01A	70 years, female, white, stage:Stage III, dead, 400 days	2233.6
TCGA-FD-A6TI-01A	73 years, male, white, stage:Stage IV, dead, 294 days	2217.2
TCGA-XF-A9SX-01A	63 years, female, white, stage:Stage IV, dead, 719 days	2210.9
TCGA-BT-A20Q-01A	73 years, male, white, stage:Stage IV, dead, 593 days	2198.7
TCGA-GU-A42P-01A	72 years, male, white, stage:Stage IV, dead, 332 days	2197.8
TCGA-FD-A3SM-01A	70 years, male, white, stage:Stage IV, dead, 547 days	2190.4
TCGA-DK-A3IM-01A	76 years, male, white, stage:Stage III, dead, 248 days	2158.8
TCGA-HQ-A5ND-01A	78 years, male, stage:Stage IV, dead, 274 days	2132.1
TCGA-5N-A9KI-01A	76 years, female, white, stage:Stage III, dead, 76 days	2117.9
TCGA-GV-A40E-01A	75 years, male, white, stage:Stage II, dead, 261 days	2099.1
TCGA-4Z-AA86-01A	66 years, male, black or african american, stage:Stage IV, dead, 311 days	2098.1
TCGA-G2-AA3C-01A	66 years, male, white, stage:Stage IV, dead, 211 days	2097.0
TCGA-SY-A9G0-01A	82 years, male, white, stage:Stage IV, dead, 1008 days	2072.6
TCGA-G2-A2EL-01A	77 years, male, white, stage:Stage II, dead, 819 days	2060.0
TCGA-BT-A20P-01A	81 years, female, white, stage:Stage III, dead, 544 days	2047.6
TCGA-FD-A3SJ-01A	59 years, male, white, stage:Stage IV, dead, 739 days	2028.1
TCGA-XF-A9SJ-01A	83 years, male, white, stage:Stage IV, dead, 98 days	2027.4
TCGA-BL-A3JM-01A	62 years, male, white, stage:Stage III, dead, 205 days	1985.5
TCGA-XF-A8HG-01A	69 years, male, white, stage:Stage III, dead, 467 days	1966.5
TCGA-BT-A3PH-01A	76 years, male, white, stage:Stage IV, dead, 142 days	1941.3
TCGA-DK-A3IK-01A	87 years, male, white, stage:Stage IV, dead, 146 days	1935.1
TCGA-FD-A3SO-01A	68 years, male, white, stage:Stage IV, dead, 168 days	1917.8
TCGA-XF-A9SK-01A	65 years, male, white, stage:Stage IV, dead, 486 days	1905.4
TCGA-FD-A6TG-01A	73 years, male, white, stage:Stage IV, dead, 93 days	1898.2
TCGA-E5-A4TZ-01A	64 years, male, white, stage:Stage IV, dead, 467 days	1879.4
TCGA-FD-A5BV-01A	47 years, female, white, stage:Stage III, dead, 163 days	1866.6
TCGA-E7-A3X6-01A	70 years, male, white, stage:Stage II, dead, 904 days	1835.4
TCGA-GV-A3QH-01A	67 years, male, white, stage:Stage II, dead, 258 days	1828.9
TCGA-ZF-A9R3-01A	53 years, female, white, stage:Stage II, dead, 949 days	1810.1
TCGA-XF-AAN4-01A	77 years, female, white, stage:Stage III, dead, 823 days	1783.0
TCGA-GC-A3I6-01A	45 years, male, white, stage:Stage III, dead, 630 days	1778.7
TCGA-GU-AATO-01A	75 years, male, white, stage:Stage IV, dead, 324 days	1745.3
TCGA-FD-A62P-01A	76 years, male, white, stage:Stage II, dead, 191 days	1730.4
TCGA-2F-A9KW-01A	67 years, female, white, stage:Stage III, dead, 254 days	1725.6
TCGA-XF-AAN2-01A	73 years, male, white, stage:Stage II, dead, 1869 days	1703.6
TCGA-HQ-A5NE-01A	57 years, male, stage:Stage III, dead, 370 days	1701.5
TCGA-4Z-AA7S-01A	66 years, male, black or african american, stage:Stage III, dead, 1064 days	1691.2
TCGA-ZF-AA4R-01A	67 years, male, white, stage:Stage IV, dead, 1036 days	1684.6
TCGA-K4-A4AC-01A	83 years, male, white, stage:Stage II, dead, 278 days	1668.4
TCGA-CU-A0YN-01A	60 years, male, white, stage:Stage III, dead, 393 days	1655.3
TCGA-FD-A3SS-01A	66 years, male, white, stage:Stage IV, dead, 391 days	1655.0
TCGA-BL-A13I-01A	57 years, female, white, stage:Stage III, dead, 223 days	1650.3
TCGA-BT-A20T-01A	63 years, male, white, stage:Stage IV, dead, 453 days	1639.3
TCGA-CU-A0YR-01A	83 years, male, white, stage:Stage IV, dead, 460 days	1637.6
TCGA-FD-A3N5-01A	69 years, male, black or african american, stage:Stage II, dead, 685 days	1628.5
TCGA-FD-A5C0-01A	61 years, male, white, stage:Stage IV, dead, 550 days	1589.6
TCGA-XF-A8HC-01A	79 years, male, asian, stage:Stage IV, dead, 200 days	1581.4
TCGA-4Z-AA7R-01A	73 years, male, black or african american, stage:Stage IV, dead, 522 days	1574.3
TCGA-DK-A3IL-01A	79 years, female, white, stage:Stage IV, dead, 413 days	1566.9
TCGA-XF-A8HH-01A	61 years, female, white, stage:Stage IV, dead, 57 days	1562.9
TCGA-DK-A1A5-01A	79 years, male, white, stage:Stage II, dead, 65 days	1517.8
TCGA-E7-A541-01A	66 years, male, white, stage:Stage II, dead, 778 days	1493.3
TCGA-BT-A20O-01A	75 years, male, white, stage:Stage III, dead, 370 days	1485.7
TCGA-4Z-AA80-01A	73 years, male, white, stage:Stage II, dead, 19 days	1424.1
TCGA-ZF-A9R9-01A	58 years, male, white, stage:Stage IV, dead, 864 days	1419.7
TCGA-ZF-AA4T-01A	65 years, male, white, stage:Stage IV, dead, 599 days	1394.3
TCGA-XF-AAME-01A	64 years, female, white, stage:Stage II, dead, 2828 days	1393.6
TCGA-FD-A62S-01A	60 years, female, black or african american, stage:Stage III, dead, 406 days	1388.3
TCGA-XF-AAMW-01A	79 years, female, white, stage:Stage IV, dead, 253 days	1358.5
TCGA-CU-A5W6-01A	70 years, male, white, stage:Stage III, dead, 56 days	1284.7
TCGA-XF-AAMX-01A	87 years, female, black or african american, stage:Stage III, dead, 206 days	1259.1
TCGA-XF-AAMJ-01A	70 years, male, asian, stage:Stage III, dead, 1670 days	1233.4
TCGA-DK-A2HX-01A	80 years, female, white, stage:Stage IV, dead, 1420 days	1189.5
TCGA-FD-A3SR-01A	68 years, male, white, stage:Stage IV, dead, 602 days	1131.4
TCGA-FD-A3SL-01A	60 years, male, white, stage:Stage IV, dead, 712 days	1070.3
TCGA-XF-A9SV-01A	82 years, male, white, stage:Stage IV, dead, 388 days	1068.9
TCGA-DK-AA6L-01A	48 years, male, white, stage:Stage IV, dead, 1163 days	1039.5
TCGA-DK-A3X2-01A	85 years, male, white, stage:Stage IV, dead, 547 days	1032.0
TCGA-ZF-A9RE-01A	78 years, female, white, stage:Stage II, dead, 106 days	982.7
TCGA-FD-A5BZ-01A	77 years, female, white, stage:Stage IV, dead, 835 days	878.0
TCGA-XF-A9SW-01A	85 years, male, white, stage:Stage IV, dead, 362 days	749.1
TCGA-XF-A9T8-01A	64 years, male, white, stage:Stage III, dead, 418 days	734.1
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UROTHELIAL CANCER - Protein expressionⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high, based on conventional immunohistochemistry profiling in selected tissues. This score is based on the combination of the staining intensity and fraction of stained cells. Each image is clickable and will lead to virtual microscopy that enables deeper exploration of all samples and also displays staining intensity scores, fraction scores and subcellular localization as well as patient and tissue information for each sample.	Antibody HPA065327
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Urothelial carcinoma, High grade
Urothelial carcinoma, Low grade
Urothelial carcinoma, NOS