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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Cancer-related genes Disease related genes Enzymes Human disease related genes Metabolic proteins Plasma proteins Potential drug targets RAS pathway related proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
16
Cytoband
q23.3
Chromosome location (bp)
81779279 - 81962685
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Hydrolase, Transducer
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Lipid degradation, Lipid metabolism
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Calcium
Gene summary (Entrez)i
Useful information about the gene from Entrez
The protein encoded by this gene is a transmembrane signaling enzyme that catalyzes the conversion of 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate to 1D-myo-inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG) using calcium as a cofactor. IP3 and DAG are second messenger molecules important for transmitting signals from growth factor receptors and immune system receptors across the cell membrane. Mutations in this gene have been found in autoinflammation, antibody deficiency, and immune dysregulation syndrome and familial cold autoinflammatory syndrome 3. [provided by RefSeq, Mar 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
H3BPZ3 [Direct mapping] Phosphoinositide phospholipase C
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Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Human disease related genes Immune system diseases Allergies and autoimmune diseases Other immune system diseases Protein evidence (Ezkurdia et al 2014)
Enzymes ENZYME proteins Hydrolases Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins RAS pathway related proteins Cancer-related genes Mutated cancer genes Disease related genes Potential drug targets Human disease related genes Immune system diseases Allergies and autoimmune diseases Other immune system diseases Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0001775[cell activation] GO:0001784[phosphotyrosine residue binding] GO:0001878[response to yeast] GO:0002092[positive regulation of receptor internalization] GO:0002223[stimulatory C-type lectin receptor signaling pathway] GO:0002224[toll-like receptor signaling pathway] GO:0002281[macrophage activation involved in immune response] GO:0002316[follicular B cell differentiation] GO:0002732[positive regulation of dendritic cell cytokine production] GO:0004435[phosphatidylinositol phospholipase C activity] GO:0004629[phospholipase C activity] GO:0005515[protein binding] GO:0005737[cytoplasm] GO:0005829[cytosol] GO:0005886[plasma membrane] GO:0006629[lipid metabolic process] GO:0006661[phosphatidylinositol biosynthetic process] GO:0007165[signal transduction] GO:0008081[phosphoric diester hydrolase activity] GO:0009395[phospholipid catabolic process] GO:0010468[regulation of gene expression] GO:0010628[positive regulation of gene expression] GO:0010634[positive regulation of epithelial cell migration] GO:0012501[programmed cell death] GO:0016042[lipid catabolic process] GO:0016055[Wnt signaling pathway] GO:0016787[hydrolase activity] GO:0019216[regulation of lipid metabolic process] GO:0019722[calcium-mediated signaling] GO:0019901[protein kinase binding] GO:0030168[platelet activation] GO:0030183[B cell differentiation] GO:0031663[lipopolysaccharide-mediated signaling pathway] GO:0032237[activation of store-operated calcium channel activity] GO:0032481[positive regulation of type I interferon production] GO:0032496[response to lipopolysaccharide] GO:0032587[ruffle membrane] GO:0032733[positive regulation of interleukin-10 production] GO:0032735[positive regulation of interleukin-12 production] GO:0032743[positive regulation of interleukin-2 production] GO:0032747[positive regulation of interleukin-23 production] GO:0032755[positive regulation of interleukin-6 production] GO:0032760[positive regulation of tumor necrosis factor production] GO:0032959[inositol trisphosphate biosynthetic process] GO:0035556[intracellular signal transduction] GO:0038095[Fc-epsilon receptor signaling pathway] GO:0043069[negative regulation of programmed cell death] GO:0043122[regulation of I-kappaB kinase/NF-kappaB signaling] GO:0043410[positive regulation of MAPK cascade] GO:0048471[perinuclear region of cytoplasm] GO:0048678[response to axon injury] GO:0050731[positive regulation of peptidyl-tyrosine phosphorylation] GO:0050850[positive regulation of calcium-mediated signaling] GO:0050852[T cell receptor signaling pathway] GO:0050853[B cell receptor signaling pathway] GO:0050896[response to stimulus] GO:0051091[positive regulation of DNA-binding transcription factor activity] GO:0051092[positive regulation of NF-kappaB transcription factor activity] GO:0051209[release of sequestered calcium ion into cytosol] GO:0060100[positive regulation of phagocytosis, engulfment] GO:0060907[positive regulation of macrophage cytokine production] GO:0061760[antifungal innate immune response] GO:0070062[extracellular exosome] GO:0070884[regulation of calcineurin-NFAT signaling cascade] GO:0071277[cellular response to calcium ion] GO:0071396[cellular response to lipid] GO:0097110[scaffold protein binding] GO:0097708[intracellular vesicle] GO:0140031[phosphorylation-dependent protein binding] GO:0150078[positive regulation of neuroinflammatory response] GO:1900227[positive regulation of NLRP3 inflammasome complex assembly] GO:1902808[positive regulation of cell cycle G1/S phase transition] GO:1903428[positive regulation of reactive oxygen species biosynthetic process] GO:1903721[positive regulation of I-kappaB phosphorylation] GO:1990782[protein tyrosine kinase binding] GO:1990858[cellular response to lectin]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Human disease related genes Immune system diseases Allergies and autoimmune diseases Other immune system diseases Protein evidence (Ezkurdia et al 2014)
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GO:0004435[phosphatidylinositol phospholipase C activity] GO:0007165[signal transduction] GO:0035556[intracellular signal transduction]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Human disease related genes Immune system diseases Allergies and autoimmune diseases Other immune system diseases Protein evidence (Ezkurdia et al 2014)
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GO:0004435[phosphatidylinositol phospholipase C activity] GO:0007165[signal transduction] GO:0035556[intracellular signal transduction]
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Human disease related genes Immune system diseases Allergies and autoimmune diseases Other immune system diseases Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Human disease related genes Immune system diseases Allergies and autoimmune diseases Other immune system diseases Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Human disease related genes Immune system diseases Allergies and autoimmune diseases Other immune system diseases Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Human disease related genes Immune system diseases Allergies and autoimmune diseases Other immune system diseases Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Human disease related genes Immune system diseases Allergies and autoimmune diseases Other immune system diseases Protein evidence (Ezkurdia et al 2014)
Metabolic proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC RAS pathway related proteins Cancer-related genes Mutated cancer genes Human disease related genes Immune system diseases Allergies and autoimmune diseases Other immune system diseases Protein evidence (Ezkurdia et al 2014)
The Human Protein Atlas project is funded
