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General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene namei
Official gene symbol, which is typically a short form of the gene name, according to HGNC.
Assigned HPA protein class(es) for the encoded protein(s).
Plasma proteins
Predicted locationi
All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions.
Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached.
Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s).
The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location.
Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Chromosome
20
Cytoband
q11.21
Chromosome location (bp)
33235995 - 33243311
Number of transcriptsi
Number of protein-coding transcripts from the gene as defined by Ensembl.
Useful information about the protein provided by UniProt.
Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC)1. Plays a role in the innate immune responses of the upper airways 2,3. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae 4,5,6. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus 7,8. Plays a role in the airway inflammatory response after exposure to irritants 9. May attract macrophages and neutrophils 10....show less
Molecular function (UniProt)i
Keywords assigned by UniProt to proteins due to their particular molecular function.
Antibiotic, Antimicrobial
Biological process (UniProt)i
Keywords assigned by UniProt to proteins because they are involved in a particular biological process.
Immunity, Innate immunity
Ligand (UniProt)i
Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.
Lipid-binding
Gene summary (Entrez)i
Useful information about the gene from Entrez
This gene is the human homolog of murine plunc, and like the mouse gene, is specifically expressed in the upper airways and nasopharyngeal regions. The encoded antimicrobial protein displays antibacterial activity against Gram-negative bacteria. It is thought to be involved in inflammatory responses to irritants in the upper airways and may also serve as a potential molecular marker for detection of micrometastasis in non-small-cell lung cancer. Multiple transcript variants resulting from alternative splicing in the 3' UTR have been detected, but the full-length nature of only three are known. [provided by RefSeq, Aug 2014]...show less
PROTEIN INFORMATIONi
The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.
The Splice variant identifier links to the Ensembl website protein summary for the selected splice variant. The data in the Swissprot and TrEMBL columns links to corresponding pages in the UniProt database.
The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.
The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide and number of predicted transmembrane region(s) according to in-house majority decision methods based on sets of predictors are also reported.
Q9NP55 [Direct mapping] BPI fold-containing family A member 1
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002376[immune system process] GO:0002395[immune response in nasopharyngeal-associated lymphoid tissue] GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0008289[lipid binding] GO:0019731[antibacterial humoral response] GO:0042742[defense response to bacterium] GO:0043129[surfactant homeostasis] GO:0045087[innate immune response] GO:0050828[regulation of liquid surface tension] GO:0050891[multicellular organismal water homeostasis] GO:0051607[defense response to virus] GO:0061844[antimicrobial humoral immune response mediated by antimicrobial peptide] GO:1900229[negative regulation of single-species biofilm formation in or on host organism] GO:1902305[regulation of sodium ion transmembrane transport]
Q9NP55 [Direct mapping] BPI fold-containing family A member 1
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Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002376[immune system process] GO:0002395[immune response in nasopharyngeal-associated lymphoid tissue] GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0008289[lipid binding] GO:0019731[antibacterial humoral response] GO:0042742[defense response to bacterium] GO:0043129[surfactant homeostasis] GO:0045087[innate immune response] GO:0050828[regulation of liquid surface tension] GO:0050891[multicellular organismal water homeostasis] GO:0051607[defense response to virus] GO:0061844[antimicrobial humoral immune response mediated by antimicrobial peptide] GO:1900229[negative regulation of single-species biofilm formation in or on host organism] GO:1902305[regulation of sodium ion transmembrane transport]
Q9NP55 [Direct mapping] BPI fold-containing family A member 1
Show all
Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins DeepTMHMM predicted secreted proteins Plasma proteins Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0002376[immune system process] GO:0002395[immune response in nasopharyngeal-associated lymphoid tissue] GO:0003674[molecular_function] GO:0005515[protein binding] GO:0005576[extracellular region] GO:0005615[extracellular space] GO:0008289[lipid binding] GO:0019731[antibacterial humoral response] GO:0042742[defense response to bacterium] GO:0043129[surfactant homeostasis] GO:0045087[innate immune response] GO:0050828[regulation of liquid surface tension] GO:0050891[multicellular organismal water homeostasis] GO:0051607[defense response to virus] GO:0061844[antimicrobial humoral immune response mediated by antimicrobial peptide] GO:1900229[negative regulation of single-species biofilm formation in or on host organism] GO:1902305[regulation of sodium ion transmembrane transport]
The Human Protein Atlas project is funded
